Nutrition, Metabolism & Cardiovascular Diseases
Volume 20, Issue 3 , Pages 157-164 , March 2010

A composite scoring of genotypes discriminates coronary heart disease risk beyond conventional risk factors in the Boston Puerto Rican Health Study

Received 9 February 2009 ,Revised 10 March 2009 ,Accepted 13 March 2009.

References 

  1. Rosamond W, Flegal K, Furie K, Go A, Greenlund K, Haase N, et al. Heart disease and stroke statistics–2008 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2008;117:e25–e146
  2. Wilson PW, D'Agostino RB, Levy D, Belanger AM, Silbershatz H, Kannel WB. Prediction of coronary heart disease using risk factor categories. Circulation. 1998;97:1837–1847
  3. Junyent M, Zambón D, Gilabert R, Núñez I, Cofán M, Ros E. Carotid atherosclerosis and vascular age in the assessment of coronary heart disease risk beyond the Framingham Risk Score. Atherosclerosis. 2008;196:803–809
  4. Vaidya D, Yanek LR, Moy TF, Pearson TA, Becker LC, Becker DM. Incidence of coronary artery disease in siblings of patients with premature coronary artery disease: 10years of follow-up. Am J Cardiol. 2007;100:1410–1415
  5. Samani NJ, Erdmann J, Hall AS, Hengstenberg C, Mangino M, Mayer B, et al. WTCCC and the Cardiogenics Consortium. Genomewide association analysis of coronary artery disease. N Engl J Med. 2007;357:443–453
  6. Yamada Y, Izawa H, Ichihara S, Takatsu F, Ishihara H, Hirayama H, et al. Prediction of the risk of myocardial infarction from polymorphisms in candidate genes. N Engl J Med. 2002;347:1916–1923
  7. Humphries SE, Cooper JA, Talmud PA, Miller GJ. Candidate gene genotypes, along with conventional risk factor assessment, improve estimation of coronary heart disease risk in healthy UK men. Clin Chem. 2007;53:8–16
  8. Morgan TM, Xiao L, Lyons P, Kassebaum B, Krumholz HM, Spertus JA. Investigation of 89 candidate gene variants for effects on all-cause mortality following acute coronary syndrome. BMC Med Genet. 2008;9:66–74
  9. Humphries SE. Cardiovascular disease risk prediction using genetic information (gene-scores): is it really informative?. Curr Opin Lipidol. 2008;19:128–132
  10. Yiannakouris N, Trichopoulou A, Benetou V, Psaltopoulou T, Ordovas JM, Trichopoulos D. A direct assessment of genetic contribution to the incidence of coronary infarct in the general population Greek EPIC cohort. Eur J Epidemiol. 2006;21:859–867
  11. Trichopoulou A, Yiannakouris N, Bamia C, Benetou V, Trichopoulos D, Ordovas JM. Genetic predisposition, nongenetic risk factors, and coronary infarct. Arch Intern Med. 2008;168:891–896
  12. Morrison AC, Bare LA, Chambless LE, Ellis SG, Mallon M, Kane JP, et al. Prediction of coronary heart disease risk using a genetic risk score: the Atherosclerosis Risk in Communities Study. Am J Epidemiol. 2007;166:28–35
  13. Kathiresan S, Melander O, Anevski D, Guiducci C, Burtt NP, Roos C, et al. Polymorphisms associated with cholesterol and risk of cardiovascular events. N Engl J Med. 2008;358:1240–1249
  14. Junyent M, Tucker KL, Smith CE, Garcia-Rios A, Mattei J, Lai CQ, et al. The effects of ABCG5/G8 polymorphisms on plasma HDL cholesterol concentrations depend on smoking habit in the Boston Puerto Rican health study. J Lipid Res. 2009;50:565–573
  15. Lee IM, Paffenbarger RS. Physical activity and stroke incidence: the Harvard Alumni Health Study. Stroke. 1998;29:2049–2054
  16. Greenland P, Smith SC, Grundy SM. Improving coronary heart disease risk assessment in asymptomatic people. The role of traditional risk factors and non-invasive cardiovascular tests. Circulation. 2001;104:1863–1867
  17. Livak KJ. Allelic discrimination using fluorogenic probes and the 5’ nuclease assay. Genet Anal. 1999;14:143–149
  18. Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection . Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Final report. Circulation. 2002;106:3143–3152
  19. Drenos F, Whittaker JC, Humphries SE. The use of meta-analysis risk estimates for candidate genes in combination to predict coronary heart disease risk. Ann Hum Genet. 2007;71:611–619
  20. Keavney B, Palmer A, Parish S, Clark S, Youngman L, Danesh J, et al. International Studies of Infarct Survival (ISIS) Collaborators Lipid-related genes and myocardial infarction in 4685 cases and 3460 controls: discrepancies between genotype, blood lipid concentrations, and coronary disease risk. Int J Epidemiol. 2004;33:1002–1013
  21. Bentzen J, Poulsen P, Vaag A, Fenger M. Further studies of the influence of apolipoprotein B alleles on glucose and lipid metabolism. Hum Biol. 2003;75:687–703
  22. Wilson PW, Myers RH, Larson MG, Ordovas JM, Wolf PA, Schaefer EJ. Apolipoprotein E alleles, dyslipidemia, and coronary heart disease. The Framingham Offspring Study. JAMA. 1994;272:1666–1671
  23. Russo GT, Meigs JB, Cupples LA, Demissie S, Otvos JD, Wilson PW, et al. Association of the Sst-I polymorphism at the APOC3 gene locus with variations in lipid levels, lipoprotein subclass profiles and coronary heart disease risk: the Framingham offspring study. Atherosclerosis. 2001;158:173–181
  24. van Bockxmeer FM, Liu Q, Mamotte C, Burke V, Taylor R. Lipoprotein lipase D9N, N291S and S447X polymorphisms: their influence on premature coronary heart disease and plasma lipids. Atherosclerosis. 2001;157:123–129
  25. Gagné SE, Larson MG, Pimstone SN, Schaefer EJ, Kastelein JJ, Wilson PW, et al. A common truncation variant of lipoprotein lipase (Ser447X) confers protection against coronary heart disease: the Framingham Offspring Study. Clin Genet. 1999;55:450–454
  26. Fish JE, Matouk CC, Yeboah E, Bevan SC, Khan M, Patil K, et al. Hypoxia-inducible expression of a natural cis-antisense transcript inhibits endothelial nitric-oxide synthase. J Biol Chem. 2007;282:15652–15666
  27. Shen J, Arnett DK, Pérez-Martínez P, Parnell LD, Lai CQ, Peacock JM, et al. The effect of IL6-174C/G polymorphism on postprandial triglyceride metabolism in the GOLDN studyboxs. J Lipid Res. 2008;49:1839–1845
  28. Karvanen J, Silander K, Kee F, Tiret L, Salomaa V, Kuulasmaa K, et al. The impact of newly identified loci on coronary heart disease, stroke and total mortality in the MORGAM prospective cohorts. Genet Epidemiol. 2009;33:237–246
  29. Beswick A, Brindle P. Risk scoring in the assessment of cardiovascular risk. Curr Opin Lipidol. 2006;14:375–386
  30. Zhang B, Menzin J, Friedman M, Korn JR, Burge RT. Predicted coronary risk for adults with coronary heart disease and low HDL-C: an analysis from the US National Health and Nutrition Examination Survey. Curr Med Res Opin. 2008;24:2711–2777

PII: S0939-4753(09)00073-8

doi: 10.1016/j.numecd.2009.03.016

Nutrition, Metabolism & Cardiovascular Diseases
Volume 20, Issue 3 , Pages 157-164 , March 2010