Nutrition, Metabolism & Cardiovascular Diseases
Volume 17, Issue 4 , Pages 274-279 , May 2007

Effect of a single high-fat meal on endothelial function in patients with the metabolic syndrome: Role of tumor necrosis factor-α

  • Katherine Esposito

      Affiliations

    • Chair and Division of Metabolic Diseases, University of Naples SUN, Piazza L. Miraglia, 80138 Naples, Italy
    • Centro di Eccellenza Cardiovascolare, University of Naples SUN, Piazza L. Miraglia, 80138 Naples, Italy
    • ,
  • Miryam Ciotola

      Affiliations

    • Chair and Division of Metabolic Diseases, University of Naples SUN, Piazza L. Miraglia, 80138 Naples, Italy
    • ,
  • Ferdinando C. Sasso

      Affiliations

    • Department of Geriatrics and Metabolic Diseases, University of Naples SUN, Piazza L. Miraglia, 80138 Naples, Italy
    • ,
  • Domenico Cozzolino

      Affiliations

    • Department of Geriatrics and Metabolic Diseases, University of Naples SUN, Piazza L. Miraglia, 80138 Naples, Italy
    • ,
  • Franco Saccomanno

      Affiliations

    • Chair and Division of Metabolic Diseases, University of Naples SUN, Piazza L. Miraglia, 80138 Naples, Italy
    • ,
  • Roberta Assaloni

      Affiliations

    • Department of Pathology and Medicine, Experimental and Clinical, University of Udine, Udine, Italy
    • ,
  • Antonio Ceriello

      Affiliations

    • Department of Pathology and Medicine, Experimental and Clinical, University of Udine, Udine, Italy
    • ,
  • Dario Giugliano

      Affiliations

    • Chair and Division of Metabolic Diseases, University of Naples SUN, Piazza L. Miraglia, 80138 Naples, Italy
    • Centro di Eccellenza Cardiovascolare, University of Naples SUN, Piazza L. Miraglia, 80138 Naples, Italy
    • Corresponding Author InformationCorresponding author. Chair and Division of Metabolic Diseases, University of Naples SUN, Piazza L. Miraglia, 80138 Naples, Italy Tel./fax: +39 081 566 5054.

Received 26 May 2005 ,Revised 27 July 2005 ,Accepted 2 November 2005.

References 

  1. Festa A, D'Agostino R, Howard G, Mykkanen L, Tracy RP, Haffner SM. Chronic subclinical inflammation as part of the insulin resistance syndrome. The Insulin Resistance Atherosclerosis Study (IRAS). Circulation. 2000;102:42–47
  2. Esposito K, Giugliano D. The metabolic syndrome and inflammation: association or causation?. Nutr Metab Cardiovasc Dis. 2004;14:228–232
  3. Pickup JC. Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes. Diabetes Care. 2004;27:813–823
  4. Plotnick GD, Corretti MC, Vogel RA. Effect of antioxidant vitamins on the transient impairment of endothelium-dependent brachial artery vasoactivity following a single high-fat meal. JAMA. 1997;278:1682–1686
  5. Nappo F, Esposito K, Cioffi M, Giugliano G, Molinari AM, Paolisso G, et al. Postprandial endothelial activation in healthy subjects and in type 2 diabetic patients: role of fat and carbohydrate meals. JACC. 2002;39:1145–1150
  6. Ferreira AC, Peter AA, Mendez AJ, Jimenez JJ, Mauro LM, Chirinos JA, et al. Postprandial hypertriglyceridemia increases circulating levels of endothelial cell microparticles. Circulation. 2004;110:3599–3603
  7. Giannattasio C, Zoppo A, Gentile G, Failla M, Capra A, Maggi FM, et al. Acute effect of high-fat meal on endothelial function in moderately dyslipidemic subjects. Arterioscler Thromb Vasc Biol. 2005;25:406–410
  8. Rask-Madsen C, Domínguez H, Ihlemann N, Hermann T, Køber L, Torp-Pedersen C. Tumor Necrosis Factor- inhibits insulin's stimulating effect on glucose uptake and endothelium-dependent vasodilation in humans. Circulation. 2003;108:1815–1821
  9. Giugliano D, Marfella R, Verrazzo G, Acampora R, Nappo F, Ziccardi P, et al. l-arginine for testing endothelium-dependent vascular functions in humans. Am J Physiol Endocrinol Metab. 1997;273:E606–E612
  10. Executive Summary of the Third Report of the national Cholesterol Education Program (NCEP) expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (ATP III). JAMA. 2001;2486–2497
  11. Esposito K, Marfella R, Ciotola M, Di Palo C, Giugliano F, Giugliano G, et al. Effect of a Mediterranean-style diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome: a randomized trial. JAMA. 2004;292:1440–1446
  12. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher F, Turner RC. Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412–419
  13. Grundy SM, Brewer HB, Cleeman JI, Smith SC, Lenfant C. Definition of metabolic syndrome. Circulation. 2004;109:433–438
  14. Lakka H-M, Laaksonen DE, Lakka TA, Niskanen LK, Kumpusalo E, Tuomilehto J, et al. The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. JAMA. 2002;288:2709–2716
  15. Ridker PM, Buring JE, Cook NR, Rifai N. C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events. Circulation. 2003;107:391–397
  16. Kleim BE, Kleim R, Lee KE. Components of the metabolic syndrome and risk of cardiovascular disease and diabetes in Beaver Dam. Diabetes Care. 2002;25:1790–1974
  17. Turhan H, Erbay AR, Yasar AS, Bicer AB, Sasmaz H, Yetkin E. Impaired coronary blood flow in patients with the metabolic syndrome: documented by thrombolysis in myocardial infarction (TIMI) frame count method. Am Heart J. 2004;148:789–794
  18. Wang TD, Chen WJ, Lin JW, Chen MF, Lee YT. Effect of rosiglitazone on endothelial function, C-reactive protein, and components of the metabolic syndrome in non-diabetic patients with the metabolic syndrome. Am J Cardiol. 2004;93:362–365
  19. Giugliano D, Marfella R, Verrazzo G, Acampora R, Coppola L, Cozzolino D, et al. The vascular effects of L-arginine in humans. The role of endogenous insulin. J Clin Invest. 1997;99:433–438
  20. Ceriello A, Quagliaro L, Piconi L, Assaloni R, Da Ros R, Maier A, et al. Effect of postprandial hypertriglyceridemia and hyperglycemia on circulating adhesion molecules and oxidative stress generation and the possible role of simvastatin treatment. Diabetes. 2004;53:701–710
  21. Karpe F, de Faire U, Mercuri M, Bond MG, Hellenius ML, Hamsten A. Magnitude of alimentary lipemia is related to intima-media thickness of the common carotid artery in middle-aged men. Atherosclerosis. 1998;141:307–314
  22. Esposito K, Nappo F, Giugliano F, Giugliano G, Marfella R, Giugliano D. Effect of dietary antioxidants on poatprandial endothelial dysfunction induced by a high-fat meal in healthy subjects. Am J Clin Nutr. 2003;77:139–143
  23. Gill JMR, Caslake MJ, McAllister C, Tsofliou F, Ferrell WR, Packard CJ, et al. Effects of short-term detraining on postprandial metabolism, endothelial function, and inflammation in endurance-trained men: dissociation between changes in triglyceride metabolism and endothelial function. J Clin Endocrinol Metab. 2003;88:4328–4335
  24. Pitsavos C, Panagiotakis DB, Chrysohoou C, Kavouras S, Stefanides C. The association between physical activity, inflammation, and coagulation markers, in people with the metabolic syndrome: the ATTICA study. Eur J Cardiovasc Prev Rehabil. 2005;12:151–158
  25. Hotamisligil GS, Arner P, Caro JF, Atkinson RL, Spiegelman BM. Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J Clin Invest. 1995;95:2409–2415
  26. Saghizadeh M, Ong JM, Garvey WT, Henty RR, Kern PA. The expression of TNF alpha by human muscle: relationship to insulin resistance. J Clin Invest. 1996;97:1111–1116
  27. Hotamisligil GS. The role of TNF and TNF receptors in obesity and insulin resistance. J Intern Med. 1999;245:621–625
  28. Kim F, Gallis B, Corson MA. TNF-alpha inhibits flow and insulin signaling leading to NO production in aortic endothelial cells. Am J Physiol Cell Physiol. 2001;280:C1057–C1065
  29. Moon YS, Kim DH, Song DK. Serum tumor necrosis factor-alpha levels and components of the metabolic syndrome in obese adolescents. Metabolism. 2004;53:863–867

PII: S0939-4753(06)00022-6

doi: 10.1016/j.numecd.2005.11.014

Nutrition, Metabolism & Cardiovascular Diseases
Volume 17, Issue 4 , Pages 274-279 , May 2007

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