Nutrition, Metabolism & Cardiovascular Diseases
Volume 18, Issue 2 , Pages 112-120 , February 2008

The effects of the surgical removal of subcutaneous adipose tissue on energy expenditure and adipocytokine concentrations in obese women

  • Luca Busetto

      Affiliations

    • Department of Medical and Surgical Sciences, Obesity Unit, University of Padova, Via Giustiniani 2, 35128 Padova, Italy
    • Corresponding Author InformationCorresponding author. Tel./fax: +39 049 821 2149.
  • ,
  • Franco Bassetto

      Affiliations

    • Institute of Plastic Surgery, University of Padova, Via Giustiniani 2, 35128 Padova, Italy
  • ,
  • Michele Zocchi

      Affiliations

    • Institute of Plastic Surgery, University of Padova, Via Giustiniani 2, 35128 Padova, Italy
  • ,
  • Francesca Zuliani

      Affiliations

    • Institute of Plastic Surgery, University of Padova, Via Giustiniani 2, 35128 Padova, Italy
  • ,
  • Maria Luisa Nolli

      Affiliations

    • Anesthesiology and Intensive Care Unit, University Hospital of Padova, Via Giustiniani 2, 35128 Padova, Italy
  • ,
  • Sabrina Pigozzo

      Affiliations

    • Department of Medical and Surgical Sciences, Obesity Unit, University of Padova, Via Giustiniani 2, 35128 Padova, Italy
  • ,
  • Alessandra Coin

      Affiliations

    • Department of Medical and Surgical Sciences, Obesity Unit, University of Padova, Via Giustiniani 2, 35128 Padova, Italy
  • ,
  • Marco Mazza

      Affiliations

    • Department of Medical and Surgical Sciences, Obesity Unit, University of Padova, Via Giustiniani 2, 35128 Padova, Italy
  • ,
  • Giuseppe Sergi

      Affiliations

    • Department of Medical and Surgical Sciences, Obesity Unit, University of Padova, Via Giustiniani 2, 35128 Padova, Italy
  • ,
  • Francesco Mazzoleni

      Affiliations

    • Institute of Plastic Surgery, University of Padova, Via Giustiniani 2, 35128 Padova, Italy
  • ,
  • Giuliano Enzi

      Affiliations

    • Department of Medical and Surgical Sciences, Obesity Unit, University of Padova, Via Giustiniani 2, 35128 Padova, Italy

Received 23 May 2006 ,Revised 9 August 2006 ,Accepted 22 September 2006.

References 

  1. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature. 1994;372:425–432
  2. Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, Boone T, et al. Effects of the obese gene product on body weight regulation in ob/ob mice. Science. 1995;269:540–543
  3. Fasshauer M, Paschke R. Regulation of adipocytokines and insulin resistance. Diabetologia. 2003;46:1594–1603
  4. Barzilai N, She L, Liu L, Wang J, Hu M, Vuguin P, et al. Surgical removal of visceral fat reverses hepatic insulin resistance. Diabetes. 1999;48:94–98
  5. Klein S, Fontana L, Leroy Young V, Coggan AR, Kilo C, Patterson BW, et al. Absence of an effect of liposuction on insulin action and risk factors for coronary heart disease. N Engl J Med. 2004;350:2549–2557
  6. Giugliano G, Nicoletti G, Grella E, Giugliano F, Esposito K, Scuderi N, et al. Effect of liposuction on insulin resistance and vascular inflammatory markers in obese women. Br J Plast Surg. 2004;57:190–194
  7. D'Andrea F, Grella R, Rizzo MR, Grella E, Grella R, Nicoletti G, et al. Changing the metabolic profile by large-volume liposuction: a clinical study conducted with 123 obese women. Aesth Plast Surg. 2005;29:472–478
  8. Economos CD, Nelson ME, Fiatarone MA, Dallal GE, Heymsfield SB, Wang J, et al. A multi-center comparison of dual energy X-ray absorptiometers: in vivo and in vitro soft tissue measurement. Eur J Clin Nutr. 1997;51:312–317
  9. Figueroa-Colon R, Mayo MS, Treuth MS, Aldridge RA, Weinsier RL. Reproducibility of dual-energy X-ray absorptiometry measurements in prepubertal girls. Obes Res. 1998;6:262–267
  10. Fuller NJ, Hardingham CR, Graves M, Screaton N, Dixon AK, Ward LC, et al. Assessment of limb muscle and adipose tissue by dual-energy X-ray absorptiometry using magnetic resonance imaging for comparison. Int J Obes. 1999;23:1295–1302
  11. Houtkooper LB, Going SB, Sproul J, Blew RM, Lohman TG. Comparison of methods for assessing body-composition changes over 1 y in postmenopausal women. Am J Clin Nutr. 2000;72:401–406
  12. Weir JB. New methods for calculating metabolic rate with special reference to protein metabolism. J Physiol. 1949;109:1–9
  13. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412–419
  14. Zocchi M. Ultrasonic liposculpturing. Aesthetic Plast Surg. 1992;16:287–298
  15. Mohamed-Ali V, Goodrick S, Rawesh A, Katz DR, Miles JM, Yudkin JS, et al. Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo. J Clin Endocrinol Metab. 1997;82:4196–4200
  16. Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR, Wright CM, et al. The hormone resistin links obesity to diabetes. Nature. 2001;409:307–312
  17. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med. 1996;334:292–295
  18. Maeda K, Okubo K, Shimonura I, Funahashi T, Matsuzawa Y, Mastubara K. cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1). Biochem Biophys Res Commun. 1996;221:286–289
  19. Fasshauer M, Kralisch S, Klier M, Lossner U, Bluher M, Klein J, et al. Adiponectin gene expression and secretion is inhibited by interleukin-6 in 3T3-L1 adipocytes. Biochem Biophys Res Commun. 2001;301:1045–1050
  20. Delporte ML, Funahashi T, Takahashi M, Matsuzawa Y, Brichard SM. Pre- and post-translational negative effect of beta-adrenergic agonists on adiponectin secretion: in vitro an in vivo studies. Biochem J. 2002;367:677–685
  21. Fasshauer M, Klein J, Neumann S, Eszlinger M, Paschke R. Hormonal regulation of adiponectin gene expression in 3T3-L1 adipocytes. Biochem Biophys Res Commun. 2002;290:1084–1089
  22. Maruna P, Gurlich R, Fried M, Frasko R, Chachkhiani I, Haluzik M. Leptin as an acute phase reactant after non-adjustable laparoscopic gastric banding. Obes Surg. 2001;11:609–614
  23. Heinrich PC, Castell JV, Andus T. Interleukin-6 and the acute phase response. Biochem J. 1990;265:621–636
  24. Senn JJ, Klover PJ, Nowak IA, Mooney RA. Interleukin-6 induces cellular insulin resistance in hepatocytes. Diabetes. 2002;51:3391–3399
  25. Rajala MW, Obici S, Scherer PE, Rossetti L. Adipose-derived resistin and gut-derived resistin-like molecole-beta selectively impari insulin action and glucose production. J Clin Invest. 2003;111:225–230
  26. Fruebis J, Tsao TS, Javorschi S, Ebbets-Reed D, Erickson MR, Yen FT, et al. Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. Proc Natl Acad Sci USA. 2001;98:2005–2010
  27. Berg AH, Combs TP, Du X, Brownlee M, Scherer PE. The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat Med. 2001;8:731–737
  28. Herndon DN, Hart DW, Wolf SE, Chinkes DL, Wolfe RR. Reversal of catabolism by beta-blockade after severe burns. N Engl J Med. 2001;345:1223–1229
  29. Uehara M, Plank LD, Hill GL. Components of energy expenditure in patients with severe sepsis and major trauma: a basis for clinical care. Crit Care Med. 1999;27:1295–1302
  30. Leibowitz SF, Wortley KE. Hypothalamic control of energy balance: different peptides, different functions. Peptides. 2004;25:473–504
  31. Rodin J, Schank D, Striegel-Moore R. Psychological features of obesity. Med Clin North Am. 1989;73:47–66
  32. Cummings DE, Weigle DS, Frayo RS, Breen PA, Ma MK, Dellinger EP, et al. Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. N Engl J Med. 2002;346:1623–1630
  33. Dulloo AG, Jacquet J. Adaptive reduction in basal metabolic rate in response to food deprivation in humans: a role for feedback signals from fat stores. Am J Clin Nutr. 1998;68:599–606
  34. Sweeney G, Keen J, Somwar R, Konrad D, Garg R, Klip A. High leptin levels acutely inhibit insulin-stimulated glucose uptake without affecting glucose transporter 4 translocation in 16 rat skeletal muscle cells. Endocrinology. 2001;142:4806–4812
  35. Fischer S, Hanefeld M, Haffner SM, Fusch C, Schwanebeck U, Kohler C, et al. Insulin-resistant patients with type 2 diabetes mellitus have higher serum leptin levels independently of body fat mass. Acta Diabetol. 2002;39:105–110
  36. Silha JV, Krsek M, Skrha JV, Sucharda P, Nyomba BKG, Muprhy LJ. Plasma resistin, adiponectin and leptin levels in lean and obese subjects: correlations with insulin resistance. Eur J Endocrinol. 2003;149:331–335
  37. Smith SR, Lovejoy JC, Greenway F, Ryan D, deJonge L, de la Bretonne J, et al. Contributions of total body fat, abdominal subcutaneous adipose tissue compartments, and visceral adipose tissue to the metabolic complications of obesity. Metabolism. 2001;50:425–435
  38. Snijder MB, Dekker JM, Visser M, Yudkin JS, Stehouwer CD, Bouter LM, et al. Larger thigh and hip circumferences are associated with better glucose tolerance: the Hoorn study. Obes Res. 2003;11:104–111

PII: S0939-4753(06)00208-0

doi: 10.1016/j.numecd.2006.09.009

Nutrition, Metabolism & Cardiovascular Diseases
Volume 18, Issue 2 , Pages 112-120 , February 2008