Nutrition, Metabolism & Cardiovascular Diseases
Volume 19, Issue 6 , Pages 401-408 , July 2009

Triglyceride/HDL-cholesterol ratio is an independent predictor for coronary heart disease in a population of Iranian men

  • F. Hadaegh

      Affiliations

    • Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University (M.C.), Tehran, Iran
    • Corresponding Author InformationCorresponding author. Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University (M.C.), P.O. Box. 19395-4763 Tehran, Iran. Tel.: +98 21 22432503; fax: +98 21 22402463.
    • ,
  • D. Khalili

      Affiliations

    • Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University (M.C.), Tehran, Iran
    • ,
  • A. Ghasemi

      Affiliations

    • Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University (M.C.), Tehran, Iran
    • ,
  • M. Tohidi

      Affiliations

    • Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University (M.C.), Tehran, Iran
    • ,
  • F. Sheikholeslami

      Affiliations

    • Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University (M.C.), Tehran, Iran
    • ,
  • F. Azizi

      Affiliations

    • Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University (M.C.), Tehran, Iran

Received 2 June 2008 ,Revised 24 August 2008 ,Accepted 5 September 2008.

References 

  1. Executive summary of the Third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). JAMA. 2001;285:2486–2497
  2. Hokanson JE, Austin MA. Plasma triglyceride level is a risk factor for cardiovascular disease independent of high-density lipoprotein cholesterol level: a meta-analysis of population-based prospective studies. J Cardiovasc Risk. 1996;3:213–219
  3. McLaughlin T, Abbasi F, Cheal K, Chu J, Lamendola C, Reaven G. Use of metabolic markers to identify overweight individuals who are insulin resistant. Ann Intern Med. 2003;139:802–809
  4. Barzi F, Patel A, Woodward M, Lawes CM, Ohkubo T, Gu D, et al. A comparison of lipid variables as predictors of cardiovascular disease in the Asia Pacific region. Ann Epidemiol. 2005;15:405–413
  5. Gaziano JM, Hennekens CH, O'Donnell CJ, Breslow JL, Buring JE. Fasting triglycerides, high-density lipoprotein, and risk of myocardial infarction. Circulation. 1997;96:2520–2525
  6. Jeppesen J, Hein HO, Suadicani P, Gyntelberg F. Low triglycerides-high high-density lipoprotein cholesterol and risk of ischemic heart disease. Arch Intern Med. 2001;161:361–366
  7. Rizos E, Mikhailidis DP. Are high-density lipoprotein and triglyceride levels important in secondary prevention: impressions from the BIP and VA-HIT trials. Int J Cardiol. 2002;82:199–207[discussion-8]
  8. Hadaegh F, Harati H, Ghanbarian A, Azizi F. Association of total cholesterol versus other serum lipid parameters with the short-term prediction of cardiovascular outcomes: Tehran Lipid and Glucose Study. Eur J Cardiovasc Prev Rehabil. 2006;13:571–577
  9. Azizi F, Rahmani M, Emami H, Mirmiran P, Hajipour R, Madjid M, et al. Cardiovascular risk factors in an Iranian urban population: Tehran Lipid and Glucose Study (phase 1). Soz Praventivmed. 2002;47:408–426
  10. Azizi F, Salehi P, Etemadi A, Zahedi-Asl S. Prevalence of metabolic syndrome in an urban population: Tehran Lipid and Glucose Study. Diabetes Res Clin Pract. 2003;61:29–37
  11. Azizi F, Raiszadeh F, Salehi P, Rahmani M, Emami H, Ghanbarian A, et al. Determinants of serum HDL-C level in a Tehran urban population: the Tehran Lipid and Glucose Study. Nutr Metab Cardiovasc Dis. 2002;12:80–89
  12. Azizi F, Rahmani M, Emami H, Madjid M. Tehran Lipid and Glucose Study: rationale and design. CVD Prevention. 2000;3:242–247
  13. Luepker RV, Apple FS, Christenson RH, Crow RS, Fortmann SP, Goff D, et al. Case definitions for acute coronary heart disease in epidemiology and clinical research studies: a statement from the AHA Council on epidemiology and prevention; AHA Statistics Committee; World Heart Federation Council on epidemiology and prevention; the European Society of Cardiology Working Group on epidemiology and prevention; Centers for Disease Control and Prevention; and the National Heart, Lung, and Blood Institute. Circulation. 2003;108:2543–2549
  14. Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care. 2003;26(Suppl. 1):S5–S20
  15. Onat A, Sari I, Yazici M, Can G, Hergenc G, Avci GS. Plasma triglycerides, an independent predictor of cardiovascular disease in men: a prospective study based on a population with prevalent metabolic syndrome. Int J Cardiol. 2006;108:89–95
  16. Grundy SM, Brewer HB, Cleeman JI, Smith SC, Lenfant C. Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Circulation. 2004;109:433–438
  17. Ford ES. The metabolic syndrome and mortality from cardiovascular disease and all-causes: findings from the National Health and Nutrition Examination Survey II Mortality Study. Atherosclerosis. 2004;173:309–314
  18. Esmaillzadeh A, Mirmiran P, Azizi F. Waist-to-hip ratio is a better screening measure for cardiovascular risk factors than other anthropometric indicators in Tehranian adult men. Int J Obes Relat Metab Disord. 2004;28:1325–1332
  19. Patel A, Huang KC, Janus ED, Gill T, Neal B, Suriyawongpaisal P, et al. Is a single definition of the metabolic syndrome appropriate? A comparative study of the USA and Asia. Atherosclerosis. 2006;184:225–232
  20. Sumner AE, Finley KB, Genovese DJ, Criqui MH, Boston RC. Fasting triglyceride and the triglyceride-HDL cholesterol ratio are not markers of insulin resistance in African Americans. Arch Intern Med. 2005;165:1395–1400
  21. Alhassan S, Kiazand A, Balise RR, King AC, Reaven GM, Gardner CD. Metabolic syndrome: do clinical criteria identify similar individuals among overweight premenopausal women?. Metabolism. 2008;57:49–56
  22. Maruyama C, Imamura K, Teramoto T. Assessment of LDL particle size by triglyceride/HDL-cholesterol ratio in non-diabetic, healthy subjects without prominent hyperlipidemia. J Atheroscler Thromb. 2003;10:186–191
  23. Dobiasova M, Frohlich J. The plasma parameter log (TG/HDL-C) as an atherogenic index: correlation with lipoprotein particle size and esterification rate in apoB-lipoprotein-depleted plasma (FERHDL). Clin Biochem. 2001;34:583–588
  24. Jia L, Long S, Fu M, Yan B, Tian Y, Xu Y, et al. Relationship between total cholesterol/high-density lipoprotein cholesterol ratio, triglyceride/high-density lipoprotein cholesterol ratio, and high-density lipoprotein subclasses. Metabolism. 2006;55:1141–1148
  25. Azizi F, Rahmani M, Ghanbarian A, Emami H, Salehi P, Mirmiran P, et al. Serum lipid levels in an Iranian adults population: Tehran Lipid and Glucose Study. Eur J Epidemiol. 2003;18:311–319
  26. Ghassemi H, Harrison G, Mohammad K. An accelerated nutrition transition in Iran. Public Health Nutr. 2002;5:149–155
  27. Parks EJ. Effect of dietary carbohydrate on triglyceride metabolism in humans. J Nutr. 2001;131:2772S–2774S
  28. Ezenwaka CE, Kalloo R. Carbohydrate-induced hypertriglyceridaemia among West Indian diabetic and non-diabetic subjects after ingestion of three local carbohydrate foods. Indian J Med Res. 2005;121:23–31
  29. Hadaegh F, Bozorgmanesh MR, Ghasemi A, Harati H, Saadat N, Azizi F. High prevalence of undiagnosed diabetes and abnormal glucose tolerance in the Iranian urban population: Tehran Lipid and Glucose Study. BMC Public Health. 2008;8:176
  30. Patel A, Barzi F, Jamrozik K, Lam TH, Ueshima H, Whitlock G, et al. Serum triglycerides as a risk factor for cardiovascular diseases in the Asia-Pacific region. Circulation. 2004;110:2678–2686

☆ Funding source: This study was supported by grant No. 121 from National Research Council of the Islamic Republic of Iran.

PII: S0939-4753(08)00187-7

doi: 10.1016/j.numecd.2008.09.003

Nutrition, Metabolism & Cardiovascular Diseases
Volume 19, Issue 6 , Pages 401-408 , July 2009

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