Nutrition, Metabolism & Cardiovascular Diseases
Volume 19, Issue 7 , Pages 504-510 , September 2009

A high menaquinone intake reduces the incidence of coronary heart disease

  • G.C.M. Gast

      Affiliations

    • Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
    • Department of Human Nutrition, Wageningen University, The Netherlands
    • Corresponding Author InformationCorresponding author. Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Room STR 6.131, PO Box 85500, 3508 GA Utrecht, The Netherlands. Tel.: +31 88 755 9360/9384 (secr); fax: +31 88 755 5485.
  • ,
  • N.M. de Roos

      Affiliations

    • Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
  • ,
  • I. Sluijs

      Affiliations

    • Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
    • Department of Human Nutrition, Wageningen University, The Netherlands
  • ,
  • M.L. Bots

      Affiliations

    • Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
  • ,
  • J.W.J. Beulens

      Affiliations

    • Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
  • ,
  • J.M. Geleijnse

      Affiliations

    • Department of Human Nutrition, Wageningen University, The Netherlands
  • ,
  • J.C. Witteman

      Affiliations

    • Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
  • ,
  • D.E. Grobbee

      Affiliations

    • Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
  • ,
  • P.H.M. Peeters

      Affiliations

    • Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
  • ,
  • Y.T. van der Schouw

      Affiliations

    • Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands

Received 27 June 2008 ,Revised 14 October 2008 ,Accepted 21 October 2008.

References 

  1. Furie B, Bouchard BA, Furie BC. Vitamin K-dependent biosynthesis of y-carboxyglutamic acid. Blood. 1999;93:1798–1808
  2. Vermeer C, Braam L. Role of K vitamins in the regulation of tissue calcification. J Bone Miner Metab. 2001;19:201–206
  3. Shanahan CM, Proudfoot D, Farzaneh-Far A, Weissberg PL. The role of Gla proteins in vascular calcification. Crit Rev Eukaryot Gene Expr. 1998;8:357–375
  4. Spronk HM, Soute BA, Schurgers LJ, Cleutjens JP, Thijssen HH, De Mey JG, et al. Matrix Gla protein accumulates at the border of regions of calcification and normal tissue in the media of the arterial vessel wall. Biochem Biophys Res Commun. 2001;289:485–490
  5. Luo G, Ducy P, McKee MD, Pinero GJ, Loyer E, Behringer RR, et al. Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein. Nature. 1997;386:78–81
  6. Price PA, Faus SA, Williamson MK. Warfarin causes rapid calcification of the elastic lamellae in rat arteries and heart valves. Arterioscler Thromb Vasc Biol. 1998;18:1400–1407
  7. Schurgers LJ, Teunissen KJ, Knapen MH, Kwaijtaal M, van DR, Appels A, et al. Novel conformation-specific antibodies against matrix gamma-carboxyglutamic acid (Gla) protein: undercarboxylated matrix Gla protein as marker for vascular calcification. Arterioscler Thromb Vasc Biol. 2005;25:1629–1633
  8. Jie K-SG, Bots ML, Vermeer C, Witteman JC, Grobbee DE. Vitamin K intake and osteocalcin levels in women with and without aortic atherosclerosis: a population-based study. Atherosclerosis. 1995;116:117–123
  9. Spronk HM, Soute BA, Schurgers LJ, Thijssen HH, De Mey JG, Vermeer C. Tissue-specific utilization of menaquinone-4 results in the prevention of arterial calcification in warfarin-treated rats. J Vasc Res. 2003;40:531–537
  10. Geleijnse JM, Vermeer C, Grobbee DE, Schurgers LJ, Knapen MH, van der Meer IM, et al. Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam study. J Nutr. 2004;134:3100–3105
  11. Erkkila AT, Booth SL, Hu FB, Jacques PF, Manson JE, Rexrode KM, et al. Phylloquinone intake as a marker for coronary heart disease risk but not stroke in women. Eur J Clin Nutr. 2005;59:196–204
  12. Erkkila AT, Booth SL, Hu FB, Jacques PF, Lichtenstein AH. Phylloquinone intake and risk of cardiovascular diseases in men. Nutr Metab Cardiovasc Dis. 2007;17:58–62
  13. Boker LK, van Noord PA, van der Schouw YT, Koot NV, de Mesquita HB, Riboli E, et al. Prospect-EPIC Utrecht: study design and characteristics of the cohort population. European Prospective Investigation into Cancer and Nutrition. Eur J Epidemiol. 2001;17:1047–1053
  14. Ocke MC, Bueno-de-Mesquita HB, Goddijn HE, Jansen A, Pols MA, Van Staveren WA, et al. The Dutch EPIC food frequency questionnaire. I. Description of the questionnaire, and relative validity and reproducibility for food groups. Int J Epidemiol. 1997;26:S37–S48
  15. Nederlands Voedingsstoffenbestand. Den Haag, Dutch: Voorlichtingsbureau voor de Voeding; 1996;
  16. Nederlands Voedingsstoffenbestand. Den Haag, Dutch: Voorlichtingsbureau voor de Voeding; 2001;
  17. Schurgers LJ, Vermeer C. Determination of phylloquinone and menaquinones in food. Haemostasis. 2000;30:298–307
  18. Suttie J. Vitamin K and human nutrition. J Am Diet Assoc. 1992;92:585–590
  19. Shearer MJ, Bach A, Kohlmeier M. Chemistry, nutritional sources, tissue distribution and metabolism of vitamin K with special reference to bone health. J Nutr. 1996;126:1181S–1186S
  20. Booth SL, Madabushi HT, Davidson KW, Sadowski JA. Tea and coffee brews are not dietary sources of vitamin K-1 (phylloquinone). J Am Diet Assoc. 1995;95:82–83
  21. Ferland G, MacDonald DL, Sadowski JA. Development of a diet low in vitamin K-1 (phylloquinone). J Am Diet Assoc. 1992;92:593–597
  22. Booth SL, Sadowski JA, Weihrauch JL, Ferland G. Vitamin K-1 (phylloquinone) content of foods: a provisional table. J Food Comp Anal. 1993;6:109–120
  23. Ocke MC, Bueno-de-Mesquita HB, Pols MA, Smit HA, Van Staveren WA, Kromhout D. The Dutch EPIC food frequency questionnaire. II. Relative validity and reproducibility for nutrients. Int J Epidemiol. 1997;26:S49–S58
  24. Herings RM, Bakker A, Stricker BH, Nap G. Pharmaco-morbidity linkage: a feasibility study comparing morbidity in two pharmacy based exposure cohorts. J Epidemiol Community Health. 1992;46:136–140
  25. Willett WC, Howe GR, Kushi LH. Adjustment for total energy intake in epidemiologic studies. Am J Clin Nutr. 1997;65:1220S–1228S
  26. Tanko LB, Christiansen C, Cox DA, Geiger MJ, McNabb MA, Cummings SR. Relationship between osteoporosis and cardiovascular disease in postmenopausal women. J Bone Miner Res. 2005;20:1912–1920
  27. Danesh J, Saracci R, Berglund G, Feskens E, Overvad K, Panico S, et al. EPIC-heart: the cardiovascular component of a prospective study of nutritional, lifestyle and biological factors in 520,000 middle-aged participants from 10 European countries. Eur J Epidemiol. 2007;22:129–141
  28. Beulens JWJ, Bots ML, Atsma F, Bartelink MLEL, Prokop M, Geleijnse JM, et al. High dietary menaquinone intake is associated with reduced coronary calcification. Atherosclerosis. 2008;
  29. Schurgers LJ, Vermeer C. Differential lipoprotein transport pathways of K-vitamins in healthy subjects. Biochim Biophys Acta. 2002;1570:27–32
  30. Cranenburg EC, Schurgers LJ, Vermeer C. Vitamin K: the coagulation vitamin that became omnipotent. Thromb Haemost. 2007;98:120–125

PII: S0939-4753(08)00209-3

doi: 10.1016/j.numecd.2008.10.004

Nutrition, Metabolism & Cardiovascular Diseases
Volume 19, Issue 7 , Pages 504-510 , September 2009