Nutrition, Metabolism & Cardiovascular Diseases
Volume 19, Issue 10 , Pages 713-719 , December 2009

Low plasma insulin-like growth factor-1 levels are associated with reduced insulin sensitivity and increased insulin secretion in nondiabetic subjects

  • E. Succurro

      Affiliations

    • Department of Experimental and Clinical Medicine, University Magna-Græcia of Catanzaro, Viale Europa, 88100 Catanzaro, Italy
  • ,
  • F. Andreozzi

      Affiliations

    • Department of Experimental and Clinical Medicine, University Magna-Græcia of Catanzaro, Viale Europa, 88100 Catanzaro, Italy
  • ,
  • M.A. Marini

      Affiliations

    • Department of Internal Medicine, University of Rome-Tor Vergata, Rome, Italy
  • ,
  • R. Lauro

      Affiliations

    • Department of Internal Medicine, University of Rome-Tor Vergata, Rome, Italy
  • ,
  • M.L. Hribal

      Affiliations

    • Department of Experimental and Clinical Medicine, University Magna-Græcia of Catanzaro, Viale Europa, 88100 Catanzaro, Italy
  • ,
  • F. Perticone

      Affiliations

    • Department of Experimental and Clinical Medicine, University Magna-Græcia of Catanzaro, Viale Europa, 88100 Catanzaro, Italy
  • ,
  • G. Sesti

      Affiliations

    • Department of Experimental and Clinical Medicine, University Magna-Græcia of Catanzaro, Viale Europa, 88100 Catanzaro, Italy
    • Corresponding Author InformationCorresponding author. Tel.: +39 0961 3647204; fax: +39 0961 3647192.

Received 4 August 2008 ,Revised 17 November 2008 ,Accepted 29 December 2008.

References 

  1. Grottoli S, Procopio M, Maccario M, Zini M, Oleandri SE, Tassone F, et al. In obesity, glucose load loses its early inhibitory, but maintains its late stimulatory, effects on somatotrope secretion. J Clin Endocrinol Metab. 1997;82:2261–2265
  2. Rasmussen MH, Hvidberg A, Juul A, Main KM, Gotfredsen A, Skakkebae NE, et al. Massive weight loss restores 24-hour growth hormone release profiles and serum insulin-like growth factor-I levels in obese subjects. J Clin Endocrinol Metab. 1995;80:1407–1415
  3. Yakar S, Liu JL, Fernandez AM, Wu Y, Schally AV, Frystyk J, et al. Liver-specific IGF-1 gene deletion leads to muscle insulin insensitivity. Diabetes. 2001;50:1110–1118
  4. Sjögren K, Wallenius K, Liu JL, Bohlooly- YM, Pacini G, Svensson L, et al. Liver-derived IGF-I is of importance for normal carbohydrate and lipid metabolism. Diabetes. 2001;50:1539–1545
  5. Leahy JL, Vandekerkhove KM. Insulin-like growth factor-I at physiological concentrations is a potent inhibitor of insulin secretion. Endocrinology. 1990;126:1593–1598
  6. Sesti G, Sciacqua A, Cardellini M, Marini MA, Maio R, Vatrano M, et al. Plasma concentration of insulin-like growth factor-I is independently associated with insulin sensitivity in subjects with different degree of glucose tolerance. Diabetes Care. 2005;28:132–137
  7. Sandhu MS, Heald AH, Gibson JM, Cruickshank JK, Dunger DB, Wareham NJ. Circulating concentrations of insulin-like growth factor-I and development of glucose intolerance: a prospective observational study. Lancet. 2002;359:1740–1745
  8. Moses AC, Young SC, Morrow LA, O'Brien M, Clemmons DR. Recombinant human insulin-like growth factor I increases insulin sensitivity and improves glycemic control in type II diabetes. Diabetes. 1996;45:91–100
  9. Morrow LA, O'Brien MB, Moller DE, Flier JS, Moses AC. Recombinant human insulin-like growth factor-I therapy improves glycemic control and insulin action in the type A syndrome of severe insulin resistance. J Clin Endocrinol Metab. 1994;79:205–210
  10. Zenobi PD, Graf S, Ursprung H, Froesch ER. Effects of insulin-like growth factor-l on glucose tolerance, insulin levels, and insulin secretion. J Clin Invest. 1992;89:1908–1913
  11. Rennert NJ, Caprio S, Sherwin RS. Insulin-like growth factor I inhibits glucose-stimulated insulin secretion but does not impair glucose metabolism in normal humans. J Clin Endocrinol Metab. 1993;76:804–806
  12. Katz LE, Ferry RJ, Stanley CA, Collett-Solberg PF, Baker L, Cohen P. Suppression of insulin oversecretion by subcutaneous recombinant human insulin-like growth factor I in children with congenital hyperinsulinism due to defective β-cell sulfonylurea receptor. J Clin Endocrinol Metab. 1999;84:3117–3124
  13. Laakso M, Zilinskaite J, Hansen T, Welløv Boesgaard T, Vänttinen M, Stančáková A, et al. for the EUGENE2 Consortium. Insulin sensitivity, insulin release and GLP-1 levels in subjects with IFG and/or IGT in the EUGENE2 study. Diabetologia. 2008;51:502–511
  14. Andreozzi F, Laratta E, Cardellini M, Marini MA, Lauro R, Hribal ML, et al. Plasma interleukin-6 levels are independently associated with insulin secretion in a cohort of italian–caucasian nondiabetic subjects. Diabetes. 2006;55:2021–2024
  15. Perticone F, Maio R, Di Paola R, Sciacqua A, Marucci A, De Cosmo S, et al. Role of PC-1 and ACE genes on insulin resistance and cardiac mass in never-treated hypertensive patients. Suggestive evidence for a digenic additive modulation. Nutr Metab Cardiovasc Dis. 2007;17:181–187
  16. Bonora E, Capaldo B, Perin PC, Del Prato S, De Mattia G, Frittitta L, et al. On behalf of the Group of Italian Scientists of Insulin Resistance (GISIR). Hyperinsulinemia and insulin resistance are independently associated with plasma lipids, uric acid and blood pressure in non-diabetic subjects. The GISIR database. Nutr Metab Cardiovasc Dis. 2008;18:624–631
  17. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412–419
  18. Korytkowski MT, Berga SL, Horwitz MJ. Comparison of the minimal model and the hyperglycemic clamp for measuring insulin sensitivity and acute insulin response to glucose. Metabolism. 1995;44:1121–1125
  19. Stumvoll M, Mitrakou A, Pimenta W, Jenssen T, Yki-Jarvinen H, Van Haeften I, et al. Use of the oral glucose tolerance test to assess insulin release and insulin sensitivity. Diabetes Care. 2000;23:295–301
  20. Bergman RN, Phillips LS, Cobelli C. Physiologic evaluation of factors controlling glucose tolerance in man: measurement of insulin sensitivity and beta-cell glucose sensitivity from the response to intravenous glucose. J Clin Invest. 1981;68:1456–1467
  21. Abdul–Ghani MA, Jenkinson CP, Richardson DK, Tripathy D, DeFronzo RA. Insulin secretion and action in subjects with impaired fasting glucose and impaired glucose tolerance: results from the Veterans Administration Genetic Epidemiology Study. Diabetes. 2006;55:1430–1435
  22. Johannsson G, Marin P, Lonn L, Ottosson M, Stenlof K, Bjorntorp P, et al. Growth hormone treatment of abdominally obese men reduces abdominal fat mass, improves glucose and lipoprotein metabolism, and reduces diastolic blood pressure. J Clin Endocrinol Metab. 1997;82:727–734
  23. Federici M, Porzio O, Lauro D, Borboni P, Giovannone B, Zucaro L, et al. Increased abundance of insulin/insulin-like growth factor-I hybrid receptors in skeletal muscle of obese subjects is correlated with in vivo insulin sensitivity. J Clin Endocrinol Metab. 1998;83:2911–2915
  24. Leung KC, Doyle N, Ballesteros M, Waters MJ, Ho KK. Insulin regulation of human hepatic growth hormone receptors: divergent effects on biosynthesis and surface translocation. J Clin Endocrinol Metab. 2000;85:4712–4720
  25. Holst JJ. The physiology of glucagon-like peptide 1. Physiol Rev. 2007;87:1409–1439
  26. Mannucci E, Rotella CM. Future perspectives on glucagon-like peptide-1, diabetes and cardiovascular risk. Nutr Metab Cardiovasc Dis. 2008;18:639–645
  27. Chiu KC, Chuang LM, Yoon C. Comparison of measured and estimated indices of insulin sensitivity and beta cell function: impact of ethnicity on insulin sensitivity and beta cell function in glucose-tolerant and normotensive subjects. J Clin Endocrinol Metab. 2001;86:1620–1625
  28. Jensen CC, Cnop M, Hull RL, Fujimoto WY, Kahn SE, American Diabetes Association GENNID Study Group . Beta-cell function is a major contributor to oral glucose tolerance in high-risk relatives of four ethnic groups in the U.S.. Diabetes. 2002;51:2170–2178
  29. Retnakaran R, Hanley AJ, Connelly PW, Sermer M, Zinman B. Ethnicity modifies the effect of obesity on insulin resistance in pregnancy: a comparison of Asian, South Asian, and Caucasian women. J Clin Endocrinol Metab. 2006;91:93–97

PII: S0939-4753(09)00006-4

doi: 10.1016/j.numecd.2008.12.011

Nutrition, Metabolism & Cardiovascular Diseases
Volume 19, Issue 10 , Pages 713-719 , December 2009