Nutrition, Metabolism & Cardiovascular Diseases
Volume 19, Issue 11 , Pages 774-780 , December 2009

Sesame supplementation does not improve cardiovascular disease risk markers in overweight men and women

Received 14 October 2008 ,Revised 24 December 2008 ,Accepted 2 January 2009.

References 

  1. Namiki M. Nutraceutical functions of sesame: a review. Crit Rev Food Sci Nutr. 2007;47:651–673
  2. Sirato-Yasumoto S, Katsuta M, Okuyama Y, Takahashi Y, Ide T. Effect of sesame seeds rich in sesamin and sesamolin on fatty acid oxidation in rat liver. J Agric Food Chem. 2001;49:2647–2651
  3. Ashakumary L, Rouyer I, Takahashi Y, Ide T, Fukuda N, Aoyama T, et al. Sesamin, a sesame lignan, is a potent inducer of hepatic fatty acid oxidation in the rat. Metabolism. 1999;48:1303–1313
  4. Hirose N, Inoue T, Nishihara K, Sugano M, Akimoto K, Shimizu S, et al. Inhibition of cholesterol absorption and synthesis in rats by sesamin. J Lipid Res. 1991;32:629–638
  5. Noguchi T, Ikeda K, Sasaki Y, Yamamoto J, Seki J, Yamagata K, et al. Effects of vitamin E and sesamin on hypertension and cerebral thrombogenesis in stroke-prone spontaneously hypertensive rats. Hypertens Res. 2001;24:735–742
  6. Nakano D, Itoh C, Takaoka M, Kiso Y, Tanaka T, Matsumura Y. Antihypertensive effect of sesamin. IV. Inhibition of vascular superoxide production by sesamin. Biol Pharm Bull. 2002;25:1247–1249
  7. Lee CC, Chen PR, Lin S, Tsai SC, Wang BW, Chen WW, et al. Sesamin induces nitric oxide and decreases endothelin-1 production in HUVECs: possible implications for its antihypertensive effect. J Hypertens. 2004;22:2329–2338
  8. Hemalatha S, Raghunath M, Ghafoorunissa . Dietary sesame oils inhibits iron-induced oxidative stress in rats. Br J Nutr. 2004;92:581–587
  9. Hsu DZ, Su SB, Chien SP, Chiang PJ, Li YH, Lo YJ, et al. Effect of sesame oil on oxidative-stress-associated renal injury in endotoxemic rats: involvement of nitric oxide and proinflammatory cytokines. Shock. 2005;24:276–280
  10. Libby P, Ridker PM, Maseri A. Inflammation and atherosclerosis. Circulation. 2002;105:1135–1143
  11. Witztum JL, Steinberg D. The oxidative modification hypothesis of atherosclerosis: does it hold for humans?. Trends Cardiovasc Med. 2001;11:93–102
  12. Penalvo JL, Heinonen SM, Aura AM, Adlercreutz H. Dietary sesamin is converted to enterolactone in humans. J Nutr. 2005;135:1056–1062
  13. Coulman KD, Liu Z, Hum WQ, Michaelides J, Thompson LU. Whole sesame seed is as rich a source of mammalian lignan precursors as whole flaxseed. Nutr Cancer. 2005;52:156–165
  14. Vanharanta M, Voutilainen S, Lakka TA, van der LM, Adlercreutz H, Salonen JT. Risk of acute coronary events according to serum concentrations of enterolactone: a prospective population-based case–control study. Lancet. 1999;354:2112–2115
  15. Vanharanta M, Voutilainen S, Rissanen TH, Adlercreutz H, Salonen JT. Risk of cardiovascular disease-related and all-cause death according to serum concentrations of enterolactone: Kuopio Ischaemic Heart Disease Risk Factor Study. Arch Intern Med. 2003;163:1099–1104
  16. Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, et al. Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation. 2005;112:2735–2752
  17. Tsai IJ, Beilin LJ, Puddey IB, Croft KD, Barden A. Impaired ex vivo leukotriene B4 production characterizes the metabolic syndrome and is improved after weight reduction. J Clin Endocrinol Metab. 2007;92:4747–4752
  18. Wu JH, Hodgson JM, Ward NC, Clarke MW, Puddey IB, Croft KD. Nitration of gamma-tocopherol prevents its oxidative metabolism by HepG2 cells. Free Radic Biol Med. 2005;39:483–494
  19. Moazzami AA, Kamal-Eldin A. Sesame seed is a rich source of dietary lignans. J Am Oil Chem Soc. 2006;83:719–723
  20. Grace PB, Taylor JI, Botting NP, Fryatt T, Oldfield MF, Bingham SA. Quantification of isoflavones and lignans in urine using gas chromatography/mass spectrometry. Anal Biochem. 2003;315:114–121
  21. Wu JH, Ward NC, Indrawan AP, Almeida CA, Hodgson JM, Proudfoot JM, et al. Effects of alpha-tocopherol and mixed tocopherol supplementation on markers of oxidative stress and inflammation in type 2 diabetes. Clin Chem. 2007;53:511–519
  22. Ward NC, Rivera J, Hodgson J, Puddey IB, Beilin LJ, Falck JR, et al. Urinary 20-hydroxyeicosatetraenoic acid is associated with endothelial dysfunction in humans. Circulation. 2004;110:438–443
  23. Hirata F, Fujita K, Ishikura Y, Hosoda K, Ishikawa T, Nakamura H. Hypocholesterolemic effect of sesame lignan in humans. Atherosclerosis. 1996;122:135–136
  24. Wu WH, Kang YP, Wang NH, Jou HJ, Wang TA. Sesame ingestion affects sex hormones, antioxidant status, and blood lipids in postmenopausal women. J Nutr. 2006;136:1270–1275
  25. Nakano D, Itoh C, Ishii F, Kawanishi H, Takaoka M, Kiso Y, et al. Effects of sesamin on aortic oxidative stress and endothelial dysfunction in deoxycorticosterone acetate–salt hypertensive rats. Biol Pharm Bull. 2003;26:1701–1705
  26. Nakano D, Kurumazuka D, Nagai Y, Nishiyama A, Kiso Y, Matsumura Y. Dietary sesamin suppresses aortic NADPH oxidase in DOCA salt hypertensive rats. Clin Exp Pharmacol Physiol. 2008;35:324–326
  27. Nakai M, Harada M, Nakahara K, Akimoto K, Shibata H, Miki W, et al. Novel antioxidative metabolites in rat liver with ingested sesamin. J Agric Food Chem. 2003;51:1666–1670
  28. Vanharanta M, Voutilainen S, Nurmi T, Kaikkonen J, Roberts LJ, Morrow JD, et al. Association between low serum enterolactone and increased plasma F2-isoprostanes, a measure of lipid peroxidation. Atherosclerosis. 2002;160:465–469
  29. Kushiro M, Takahashi Y, Ide T. Species differences in the physiological activity of dietary lignan (sesamin and episesamin) in affecting hepatic fatty acid metabolism. Br J Nutr. 2004;91:377–386
  30. Nakano D, Kwak CJ, Fujii K, Ikemura K, Satake A, Ohkita M, et al. Sesamin metabolites induce an endothelial nitric oxide-dependent vasorelaxation through their antioxidative property-independent mechanisms: possible involvement of the metabolites in the antihypertensive effect of sesamin. J Pharmacol Exp Ther. 2006;318:328–335

☆ This study was funded by the National Health and Medical Research Council (NHMRC) of Australia (project grant 403957). JW acknowledges the assistance of a Faculty of Medicine, Dentistry and Health Sciences Fellowship from the University of Western Australia.

PII: S0939-4753(09)00011-8

doi: 10.1016/j.numecd.2009.01.003

Nutrition, Metabolism & Cardiovascular Diseases
Volume 19, Issue 11 , Pages 774-780 , December 2009

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