Nutrition, Metabolism & Cardiovascular Diseases
Volume 19, Issue 11 , Pages 767-773 , December 2009

Dietary and supplementary betaine: Effects on betaine and homocysteine concentrations in males

  • W. Atkinson

      Affiliations

    • Clinical Biochemistry Unit, Canterbury Health Laboratories, P.O. Box 151, Christchurch Mail Centre, Christchurch, New Zealand
    • ,
  • S. Slow

      Affiliations

    • Clinical Biochemistry Unit, Canterbury Health Laboratories, P.O. Box 151, Christchurch Mail Centre, Christchurch, New Zealand
    • Corresponding Author InformationCorresponding author. Tel.: +64 3 3640122; fax: +64 3 3640750.
    • ,
  • J. Elmslie

      Affiliations

    • Clinical Biochemistry Unit, Canterbury Health Laboratories, P.O. Box 151, Christchurch Mail Centre, Christchurch, New Zealand
    • ,
  • M. Lever

      Affiliations

    • Clinical Biochemistry Unit, Canterbury Health Laboratories, P.O. Box 151, Christchurch Mail Centre, Christchurch, New Zealand
    • ,
  • S.T. Chambers

      Affiliations

    • Pathology Department, University of Otago, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
    • ,
  • P.M. George

      Affiliations

    • Clinical Biochemistry Unit, Canterbury Health Laboratories, P.O. Box 151, Christchurch Mail Centre, Christchurch, New Zealand
    • Pathology Department, University of Otago, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand

Received 15 November 2008 ,Revised 13 January 2009 ,Accepted 16 January 2009.

References 

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  2. de Zwart FJ, Slow S, Payne RJ, Lever M, George PM, Gerrard JA, et al. Glycine betaine and glycine betaine analogues in common foods. Food Chem. 2003;83:197–204
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  5. Lever M, George PM, Dellow WJ, Scott RS, Chambers ST. Homocysteine, glycine betaine, and N,N-dimethylglycine in patients attending a lipid clinic. Metabolism. 2005;54:1–14
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  16. Schwab U, Torronen A, Meririnne E, Saarinen M, Alfthan G, Aro A, et al. Orally administered betaine has an acute and dose-dependent effect on serum betaine and plasma homocysteine concentrations in healthy humans. J Nutr. 2006;136:34–38
  17. Atkinson W, Elmslie J, Lever M, Chambers ST, George PM. Dietary and supplementary betaine: acute effects on plasma betaine and homocysteine concentrations under standard and post methionine load conditions in healthy male subjects. Am J Clin Nutr. 2008;87:577–585
  18. Knopman D, Patterson M. An open-label 24-week pilot study of the methyl donor betaine in Alzheimer disease patients. Alzheimer Dis Assoc Disord. 2001;15:162–165
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  28. Finkelstein JD, Harris BJ, Martin JJ, Kyle WE. Regulation of hepatic betaine-homocysteine methyltransferase by dietary methionine. Biochem Biophys Res Commun. 1982;108:344–348
  29. Olthof MR, van Vliet T, Verhoef P, Zock PL, Katan MB. Effect of homocysteine-lowering nutrients on blood lipids: results from four randomised, placebo-controlled studies in healthy humans. PLoS Med. 2005;2:e135

☆ Research Support: This study was supported by a grant from the National Heart Foundation of New Zealand (to PMG) and S. Slow was supported by a grant from the Neurological Foundation of New Zealand.

PII: S0939-4753(09)00012-X

doi: 10.1016/j.numecd.2009.01.004

Nutrition, Metabolism & Cardiovascular Diseases
Volume 19, Issue 11 , Pages 767-773 , December 2009

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