Intake of the plant lignans matairesinol, secoisolariciresinol, pinoresinol, and lariciresinol in relation to vascular inflammation and endothelial dysfunction in middle age-elderly men and post-menopausal women living in Northern Italy

Abstract 

Background and aims

It has been suggested that lignan intake may decrease the risk for cardiovascular disease (CVD) by modifying traditional risk factors as well as aortic stiffness. However, the role of dietary lignans on the vascular system is largely unknown. The objective was to investigate whether dietary intake of plant lignans in a free-living population was associated with markers of vascular inflammation and function.

Methods and Results

We performed a cross-sectional study in 242 (151 males) men and post-menopausal women. Anthropometric characteristics and lignan intake were evaluated. Soluble intercellular adhesion molecule-1 (sICAM-1), insulin, high-sensitive C-reactive protein, glucose, total cholesterol, HDL-cholesterol and triacylglycerols were measured in fasting blood samples. Brachial flow-mediated dilation (FMD) measurements were available for 101 subjects (56 males). Median (interquartile range) daily intake of matairesinol (MAT), secoisolariciresinol (SECO), pinoresinol (PINO), lariciresinol (LARI), and total lignans was 20.9 μg (17.4), 335.3 μg (289.1), 96.7 μg (91.1), 175.7 μg (135.8), and 665.5 μg (413.7), respectively, as assessed by 3-day weighed food record. Plasma concentrations of sICAM-1 (whole sample) significantly decreased (mean (95%CI) = 358 μg/L (320–401), 276 μg/L (252–303), 298 μg/L (271–326), and 269 μg/L (239–303), P per trend 0.013) and FMD values (FMD sub-group) significantly increased (4.1% (2.2–6.0), 5.7% (4.3–7.2), 6.4% (4.9–7.8), and 8.1% (6.3–10.0), P per trend 0.016) across quartiles of energy-adjusted MAT intake, even after adjustment for relevant clinical and dietary variables. Intake of SECO was also inversely related to plasma sICAM-1 (P per trend 0.018), but not to FMD values. No relationship between intake of PINO, LARI or total lignans and either sICAM-1 or FMD values was observed.

Conclusions

Higher MAT intakes in the context of a typical Northern Italian diet are associated to lower vascular inflammation and endothelial dysfunction, which could have some implications in CVD prevention.

Keywords: Plant lignans, Matairesinol, Secoisolariciresinol, Pinoresinol, Lariciresinol, Flow-mediated dilation, Soluble intercellular adhesion molecule-1

Abbreviations used: CVD, cardiovascular disease, sICAM-1, soluble intercellular adhesion molecule-1, FMD, brachial flow-mediated dilation, MAT, matairesinol, SECO, secoisolariciresinol, PINO, pinoresinol, LARI, lariciresinol, PA, physical activity, 3D-WR, 3-d weighed food record, TAC, total antioxidant capacity, NG, nitro-glycerin, hs-CRP, high-sensitivity C-reactive protein, CHD, coronary heart disease, MMP-7, matrix metalloproteinase 7