Nutrition, Metabolism & Cardiovascular Diseases
Volume 20, Issue 1 , Pages 15-21 , January 2010

Glycosylated hemoglobin and the risk of death and cardiovascular mortality in the elderly

  • M. Chonchol

      Affiliations

    • University of Colorado Health Sciences Center, Division of Renal Diseases and Hypertension, Box C-280, Denver, CO 80262, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 303 399 6997; fax: +1 303 399 3131.
    • ,
  • R. Katz

      Affiliations

    • Collaborative Health Studies Coordinating Center, University of Washington, Seattle, WA, USA
    • ,
  • L.F. Fried

      Affiliations

    • Veterans Affairs Pittsburgh Healthcare System, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    • University of Pittsburgh Graduate School of Public Health, Department of Epidemiology, Pittsburgh, PA, USA
    • ,
  • M.J. Sarnak

      Affiliations

    • Department of Medicine, Tufts Medical Center, Boston, MA, USA
    • ,
  • D.S. Siscovick

      Affiliations

    • University of Washington, Departments of Medicine and Epidemiology, Cardiovascular Health Research Unit, Seattle, WA, USA
    • ,
  • A.B. Newman

      Affiliations

    • University of Pittsburgh Graduate School of Public Health, Department of Epidemiology, Pittsburgh, PA, USA
    • ,
  • E.S. Strotmeyer

      Affiliations

    • University of Pittsburgh Graduate School of Public Health, Department of Epidemiology, Pittsburgh, PA, USA
    • ,
  • A. Bertoni

      Affiliations

    • Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA
    • ,
  • M.G. Shlipak

      Affiliations

    • University of California San Francisco, General Internal Medicine Section, Veterans Affairs Medical Center, University of California, San Francisco, CA, USA

Received 8 October 2008 ,Revised 6 February 2009 ,Accepted 17 February 2009.

References 

  1. Coutinho M, Gerstein HC, Wang Y, Yusuf S. The relationship between glucose and incident cardiovascular events. A metaregression analysis of published data from 20 studies of 95,783 individuals followed for 12.4years. Diabetes Care. 1999;22:233–240
  2. Khaw KT, Wareham N, Bingham S, Luben R, Welch A, Day N. Association of hemoglobin A1c with cardiovascular disease and mortality in adults: the European prospective investigation into cancer in Norfolk. Ann Intern Med. 2004;141:413–420
  3. Misciagna G, De Michele G, Trevisan M. Non enzymatic glycated proteins in the blood and cardiovascular disease. Curr Pharm Des. 2007;13:3688–3695
  4. Zieman SJ, Kass DA. Advanced glycation endproduct crosslinking in the cardiovascular system: potential therapeutic target for cardiovascular disease. Drugs. 2004;64:459–470
  5. Koenig RJ, Peterson CM, Jones RL, Saudek C, Lehrman M, Cerami A. Correlation of glucose regulation and hemoglobin A1c in diabetes mellitus. N Engl J Med. 1976;295:417–420
  6. Tahara Y, Shima K. Kinetics of HbA1c, glycated albumin, and fructosamine and analysis of their weight functions against preceding plasma glucose level. Diabetes Care. 1995;18:440–447
  7. Marshall SM, Barth JH. Standardization of HbA1c measurements – a consensus statement. Diabet Med. 2000;17:5–6
  8. Gerstein HC, Pogue J, Mann JF, Lonn E, Dagenais GR, McQueen M, et al. The relationship between dysglycaemia and cardiovascular and renal risk in diabetic and non-diabetic participants in the HOPE study: a prospective epidemiological analysis. Diabetologia. 2005;248:1749–1755
  9. Levitan EB, Liu S, Stampfer MJ, Cook NR, Rexrode KM, Ridker PM, et al. HbA(1c) measured in stored erythrocytes and mortality rate among middle-aged and older women. Diabetologia. 2008;51:267–275
  10. Pradhan AD, Rifai N, Buring JE, Ridker PM. Hemoglobin A1c predicts diabetes but not cardiovascular disease in nondiabetic women. Am J Med. 2007;120:720–727
  11. Selvin E, Coresh J, Golden SH, Brancati FL, Folsom AR, Steffes MW. Glycemic control and coronary heart disease risk in persons with and without diabetes: the atherosclerosis risk in communities study. Arch Intern Med. 2005;165:1910–1916
  12. Blake GJ, Pradhan AD, Manson JE, Williams GR, Buring J, Ridker PM, et al. Hemoglobin A1c level and future cardiovascular events among women. Arch Intern Med. 2004;164:757–761
  13. Selvin E, Coresh J, Shahar E, Zhang L, Steffes M, Sharrett AR. Glycaemia (haemoglobin A1c) and incident ischaemic stroke: the Atherosclerosis Risk in Communities (ARIC) Study. Lancet Neurol. 2005;4:821–826
  14. Park S, Barrett-Connor E, Wingard DL, Shan J, Edelstein S. GHb is a better predictor of cardiovascular disease than fasting or postchallenge plasma glucose in women without diabetes. The Rancho Bernardo Study. Diabetes Care. 1996;19:450–456
  15. Fried LP, Borhani NO, Enright P, Furberg CD, Gardin JM, Kronmal RA, et al. The Cardiovascular Health Study: design and rationale. Ann Epidemiol. 1991;1:263–276
  16. Cushman M, Cornell ES, Howard PR, Bovill EG, Tracy RP. Laboratory methods and quality assurance in the Cardiovascular Health Study. Clin Chem. 1995;41:264–270
  17. Ives DG, Fitzpatrick AL, Bild DE, Psaty BM, Kuller LH, Crowley PM, et al. Surveillance and ascertainment of cardiovascular events. The Cardiovascular Health Study. Ann Epidemiol. 1995;5:278–285
  18. Shlipak MG, Sarnak MJ, Katz R, Fried LF, Seliger SL, Newman AB, et al. Cystatin C and the risk of death and cardiovascular events among elderly persons. N Engl J Med. 2005;352:2049–2060
  19. Psaty BM, Lee M, Savage PJ, Rutan GH, German PS, Lyles M. Assessing the use of medications in the elderly: methods and initial experience in the Cardiovascular Health Study. The Cardiovascular Health Study Collaborative Research Group. J Clin Epidemiol. 1992;45:683–692
  20. Shlipak MG, Fried LF, Cushman M, Manolio TA, Peterson D, Stehman-Breen C, et al. Cardiovascular mortality risk in chronic kidney disease: comparison of traditional and novel risk factors. JAMA. 2005;293:1737–1745
  21. Levey AS, Coresh J, Balk E, Kausz AT, Levin A, Steffes MW, et al. National Kidney Foundation National Kidney Foundation practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Ann Intern Med. 2003;139:137–147
  22. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972;18:499–502
  23. Macy EM, Hayes TE, Tracy RP. Variability in the measurement of C-reactive protein in healthy subjects: implications for reference intervals and epidemiological applications. Clin Chem. 1997;43:52–58
  24. de Vegt F, Dekker JM, Ruhé HG, Stehouwer CD, Nijpels G, Bouter LM, et al. Hyperglycaemia is associated with all-cause and cardiovascular mortality in the Hoorn population: the Hoorn Study. Diabetologia. 1999;42:926–931
  25. Meigs JB, Nathan DM, D'Agostino RB, Wilson PW. Framingham Offspring Study. Fasting and postchallenge glycemia and cardiovascular disease risk: the Framingham Offspring Study. Diabetes Care. 2002;25:1845–1850

PII: S0939-4753(09)00041-6

doi: 10.1016/j.numecd.2009.02.007

Nutrition, Metabolism & Cardiovascular Diseases
Volume 20, Issue 1 , Pages 15-21 , January 2010

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