Nutrition, Metabolism & Cardiovascular Diseases
Volume 20, Issue 2 , Pages 87-92 , February 2010

Lifestyle intervention improves microvascular reactivity and increases serum adiponectin in overweight hypertensive patients

  • L. Pasqualini

      Affiliations

    • Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    • Corresponding Author InformationCorresponding author. Unit of Internal Medicine, Angiology and Arteriosclerosis, Department of Clinical and Experimental Medicine, University of Perugia School of Medicine, Hospital “Santa Maria della Misericordia”, Piazzale Menghini, 1 - 06129 Perugia, Italy. Tel.: +39 0755784016; fax: +39 0755784022.
  • ,
  • G. Schillaci

      Affiliations

    • Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
  • ,
  • S. Innocente

      Affiliations

    • Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
  • ,
  • G. Pucci

      Affiliations

    • Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
  • ,
  • F. Coscia

      Affiliations

    • Interfaculty School for Motor Sciences, University of Perugia, Perugia, Italy
  • ,
  • D. Siepi

      Affiliations

    • Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
  • ,
  • G. Lupattelli

      Affiliations

    • Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
  • ,
  • G. Ciuffetti

      Affiliations

    • Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
  • ,
  • E. Mannarino

      Affiliations

    • Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy

Received 15 September 2008 ,Revised 28 February 2009 ,Accepted 2 March 2009.

References 

  1. Thomas GN, Ho SY, Lam KS, Janus ED, Hedley AJ, Lam TH, et al. Impact of obesity and body fat distribution on cardiovascular risk factors in Hong Kong Chinese. Obes Res. 2004;12:1805–1813
  2. Ruan H, Lodish HF. Regulation of insulin sensitivity by adipose tissue derived hormones and inflammatory cytokines. Curr Opin Lipidol. 2004;15:297–302
  3. Chow W-S, Cheung BMY, Tso AWK, Xu A, Wat NMS, Fong CHY, et al. Hypoadiponectinemia as a predictor for the development of hypertension: a 5-year prospective study. Hypertension. 2007;49:1455–1461
  4. Ouchi N, Ohishi M, Kihara S, Funahashi T, Nakamura T, Nagaretani H, et al. Association of hypoadiponectinemia with impaired vasoreactivity. Hypertension. 2003;42:231–234
  5. Ciuffetti G, Pasqualini L, Pirro M, Lombardini R, De Sio M, Schillaci G, et al. Blood rheology in men with essential hypertension and capillary rarefaction. J Hum Hypertens. 2002;16:533–537
  6. Ciuffetti G, Schillaci G, Innocente S, Lombardini R, Pasqualini L, Notaristefano S, et al. Capillary rarefaction and abnormal cardiovascular reactivity in hypertension. J Hypertens. 2003;21:2297–2303
  7. Vicaut E. Microcirculation and arterial hypertension. Drugs. 1999;59(Spec No):1–10
  8. Rossi M, Taddei S, Fabbri A, Tintori G, Credidio L, Virdis A, et al. Cutaneous vasodilation to acetylcholine in patients with essential hypertension. J Cardiovasc Pharmacol. 1997;29:406–411
  9. Lindstedt IH, Edvinsson ML, Edvinsson L. Reduced responsiveness of cutaneous microcirculation in essential hypertension – a pilot study. Blood Press. 2006;15:275–280
  10. The seventh report of the joint national committee on prevention detection, evaluation and treatment of high blood pressure: the JNC 7 report. JAMA. 2003;289:2560–2571
  11. Pagani M, Somers V, Furlan R, Dell'Orto S, Conway J, Baselli G, et al. Changes in autonomic regulation induced by physical training in mild hypertension. Hypertension. 1988;12:600–610
  12. Kvernmo HD, Stefanovska A, Kirkeboen KA, Osterud B, Kvernebo K. Enhanced endothelium-dependent vasodilatation in human skin vasculature induced by physical conditioning. Eur J Appl Physiol Occup Physiol. 1998;79:30–36
  13. Lenasi H, Strucl M. Effect of regular physical training on cutaneous microvascular reactivity. Med Sci Sports Exerc. 2004;36:606–612
  14. Schillaci G, Pasqualini L, Vaudo G, Lupattelli G, Pirro M, Marchesi S, et al. Prognostic value of treatment-induced changes in twenty-four-hour mean and pulse pressures in adult hypertensive patients. Am J Cardiol. 2002;90:896–899
  15. Binggeli C, Spieker LE, Corti R, Sudano I, Stojanovic V, Hayoz D, et al. Statins enhance postischemic hyperemia in the skin circulation of hypercholesterolemic patients: a monitoring test of endothelial dysfunction for clinical practice?. J Am Coll Cardiol. 2003;42:71–77
  16. American College of Sports Medicine . Guidelines of exercise testing and prescription. Baltimore: Williams and Wilkins; 2004;p. 1–373
  17. Astrand PO, Rihming I. A nomogram for calculation of aerobic capacity (fisical fitness) from pulse rate during submaximal work. J Appl Physiol. 1954;7:218–221
  18. Byrne NM, Hills AP. Relationships between HR and VO(2) in the obese. Med Sci Sports Exerc. 2002;34:1419–1427
  19. American College of Sports Medicine Position Stand . Physical activity, physical fitness, and hypertension. Med Sci Sports Exerc. 1993;25:1–9
  20. Marchesi S, Pasqualini L, Lombardini R, Vaudo G, Lupattelli G, Pirro M, et al. Prostaglandin E1 improves endothelial function in critical limb ischemia. J Cardiovasc Pharmacol. 2003;41:249–253
  21. Panza JA, Quyyumi AA, Brush JE, Epstein SE. Abnormal endothelium-dependent vascular relaxation in patients with essential hypertension. N Engl J Med. 1990;323:22–27
  22. Higashi Y, Sasaki S, Kurisu S, Yoshimizu A, Sasaki N, Matsuura H, et al. Regular aerobic exercise augments endothelium-dependent vascular relaxation in normotensive as well as hypertensive subjects: role of endothelium-derived nitric oxide. Circulation. 1999;100:1194–1202
  23. Tjønna AE, Lee SJ, Rognmo O, Stølen TO, Bye A, Haram PM, et al. Aerobic interval training versus continuous moderate exercise as a treatment for the metabolic syndrome: a pilot study. Circulation. 2008;118:346–354
  24. Wang JS. Effects of exercise training and detraining on cutaneous microvascular function in man: the regulatory role of endothelium-dependent dilation in skin vasculature. Eur J Appl Physiol. 2005;93:429–434
  25. DeSouza CA, ShapiroLF , Clevenger CM, Dinenno FA, Monahan KD, Tanaka KAH, et al. Regular aerobic exercise prevents and restores age-related declines in endothelium-dependent vasodilation in healthy men. Circulation. 2000;102:1351–1357
  26. Stewart J, Kohen A, Brouder D, Rahim F, Adler S, Garrick R, et al. Noninvasive interrogation of microvasculature for signs of endothelial dysfunction in patients with chronic renal failure. Am J Physiol Heart Circ Physiol. 2004;287:H2687–H2696
  27. Cupisti A, Rossi M, Placidi S, Fabbri A, Morelli E, Vagheggini G, et al. Responses of the skin microcirculation to acetylcholine in patients with essential hypertension and in normotensive patients with chronic renal failure. Nephron. 2000;85:114–119
  28. Kvandal P, Stefanovska A, Veber M, Kvernmo HD, Kirkebøen KA. Regulation of human cutaneous circulation evaluated by laser Doppler flowmetry, iontophoresis, and spectral analysis: importance of nitric oxide and prostaglandines. Microvasc Res. 2003;65:160–171
  29. Winterfeld HJ, Strangfeld D, Siewert H. The behavior of blood pressure and peripheral hemodynamics in regular exercise therapy in patients with essential hypertension (stages I and II) of various age groups. Z Gesamte Inn Med. 1982;37:561–563
  30. Simpson KA, Singh MA. Effects of exercise on adiponectin: a systematic review. Obesity (Silver Spring). 2008;16:241–256
  31. Schillaci G, Pirro M. Hypoadiponectinemia: a novel link between obesity and hypertension?. Hypertension. 2007;49:1217–1219
  32. Han SH, Quon MJ, Kim J, Koh KK. Adiponectin and cardiovascular disease: response to therapeutic intervention. J Am Coll Cardiol. 2007;49:531–538
  33. Myers J, Prakash M, Froelicher V, Do D, Partington S, Atwood JE. Exercise capacity and mortality among men referred for exercise testing. N Engl J Med. 2002;346:793–801
  34. Sui X, LaMonte MJ, Laditka JN, Hardin JW, Chase N, Hooker SP, et al. Cardiorespiratory fitness and adiposity as mortality predictors in older adults. JAMA. 2007;298:2507–2516

PII: S0939-4753(09)00059-3

doi: 10.1016/j.numecd.2009.03.002

Nutrition, Metabolism & Cardiovascular Diseases
Volume 20, Issue 2 , Pages 87-92 , February 2010