Nutrition, Metabolism & Cardiovascular Diseases
Volume 20, Issue 2 , Pages 117-124 , February 2010

Effects of a dairy product (pecorino cheese) naturally rich in cis-9, trans-11 conjugated linoleic acid on lipid, inflammatory and haemorheological variables: A dietary intervention study

  • F. Sofi

      Affiliations

    • Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Italy
    • Regional Agency of Nutrition, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy
    • Don Carlo Gnocchi Foundation, Onlus IRCCS, Impruneta, Florence, Italy
    • Centro Interdipartimentale per la Ricerca e la Valorizzazione degli Alimenti (CeRA), University of Florence, Italy
    • Corresponding Author InformationCorresponding author. Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence. Viale Morgagni 85, 50134 Florence, Italy. Tel.: +39 055 7949420; fax: +39 055 7949418.
    • ,
  • A. Buccioni

      Affiliations

    • Dipartimento di Scienze Zootecniche, Facoltà di Agraria, University of Florence, Italy
    • Centro Interdipartimentale per la Ricerca e la Valorizzazione degli Alimenti (CeRA), University of Florence, Italy
    • ,
  • F. Cesari

      Affiliations

    • Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Italy
    • ,
  • A.M. Gori

      Affiliations

    • Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Italy
    • Don Carlo Gnocchi Foundation, Onlus IRCCS, Impruneta, Florence, Italy
    • Centro Interdipartimentale per la Ricerca e la Valorizzazione degli Alimenti (CeRA), University of Florence, Italy
    • ,
  • S. Minieri

      Affiliations

    • Dipartimento di Scienze Zootecniche, Facoltà di Agraria, University of Florence, Italy
    • Centro Interdipartimentale per la Ricerca e la Valorizzazione degli Alimenti (CeRA), University of Florence, Italy
    • ,
  • L. Mannini

      Affiliations

    • Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Italy
    • ,
  • A. Casini

      Affiliations

    • Regional Agency of Nutrition, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy
    • Centro Interdipartimentale per la Ricerca e la Valorizzazione degli Alimenti (CeRA), University of Florence, Italy
    • ,
  • G.F. Gensini

      Affiliations

    • Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Italy
    • Don Carlo Gnocchi Foundation, Onlus IRCCS, Impruneta, Florence, Italy
    • ,
  • R. Abbate

      Affiliations

    • Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Italy
    • Centro Interdipartimentale per la Ricerca e la Valorizzazione degli Alimenti (CeRA), University of Florence, Italy
    • ,
  • M. Antongiovanni

      Affiliations

    • Dipartimento di Scienze Zootecniche, Facoltà di Agraria, University of Florence, Italy
    • Centro Interdipartimentale per la Ricerca e la Valorizzazione degli Alimenti (CeRA), University of Florence, Italy

Received 16 December 2008 ,Revised 27 February 2009 ,Accepted 6 March 2009.

References 

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  2. Luna P, Fontecha J, Juarez M, de la Fuente MA. Conjugated linoleic acid in ewe milk fat. J Dairy Res. 2005;72:415–424
  3. Dhiman TR, Nam SH, Ure AL. Factors affecting conjugated linoleic acid content in milk and fat. Crit Rev Food Sci Nutr. 2005;45:463–482
  4. Bhattacharya A, Banu J, Rahman M, Causey J, Fernandes G. Biological effects of conjugated linoleic acids in health and disease. J Nutr Biochem. 2006;17:789–810
  5. Kuhnt K, Kraft J, Vogelsang H, Eder K, Kratzsch J, Jahreis G. Dietary supplementation with trans-11-conjugated linoleic acid in human immune cells, but without effects on biomarkers of immune function and inflammation. Br J Nutr. 2007;97:1196–1205
  6. Silveira MB, Carraro R, Monereo S, Tebar J. Conjugated linoleic acid (CLA) and obesity. Public Health Nutr. 2007;10:1181–1186
  7. Burdge GC, Tricon S, Morgan R, Kliem KE, Childs C, Jones E, et al. Incorporation of cis-9, trans-11 conjugated linoleic acid and vaccenic acid (trans-11 18:1) into plasma and leucocyte lipids in healthy men consuming dairy products naturally enriched in these fatty acids. Br J Nutr. 2005;94:237–243
  8. Association of Official Analytical Chemists.Official Methods of Analysis, AOAC. 15th Edition. Arlington, VA.
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  10. Christie WW. A simple procedure for rapid trans-methylation of glycerolipids and cholesterol esters. J Lipid Res. 1982;23:1072–1075
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  12. Kramer JKG, Cruz-Hernandez C, Deng ZY, Zhou JQ, Jahreis G, Dugan MER. Analysis of conjugated linoleic acid and trans 18:1 isomers in synthetic and animal products. Am J Clin Nutr. 2004;79:1137S–1145S
  13. Addis M, Cabiddu A, Pinna G, Decandia M, Piredda G, Pirisi A, et al. Milk and cheese fatty acid composition in sheep fed Mediterranean forages with reference to conjugated linoleic acid cis-9, trans-11. J Dairy Sci. 2005;88:3443–3454
  14. Nestel P, Fujii A, Allen T. The cis-9, trans-11 isomer of conjugated linoleic acid (CLA) lowers plasma triglyceride and raises HDL cholesterol concentrations but does not suppress aortic atherosclerosis in diabetic apoE-deficient mice. Atherosclerosis. 2006;189:282–287
  15. Tricon S, Burdge GC, Kew S, Banerjee T, Russell JJ, Jones EL, et al. Opposing effects of cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acid on blood lipids in healthy humans. Am J Clin Nutr. 2004;80:614–620
  16. Tricon S, Burdge GC, Jones EL, Russell JJ, El-Khazen S, Moretti E, et al. Effects of dairy products naturally enriched with cis-9, trans-11 conjugated linoleic acid on the blood lipid profile in healthy middle-aged men. Am J Clin Nutr. 2006;83:744–753
  17. Tholstrup T, Raff M, Straarup EM, Lund P, Basu S, Bruun JM. An oil mixture with trans-10, cis-12 conjugated linoleic acid increases markers of inflammation and in vivo lipid peroxidation compared with cis-9, trans-11 conjugated linoleic acid in postmenopausal women. J Nutr. 2008;138:1445–1451
  18. Moloney F, Toomey S, Noone E, Nugent A, Allan B, Loscher CE, et al. Antidiabetic effects of cis-9, trans-11-conjugated linoleic acid may be mediated via anti-inflammatory effects in white adipose tissue. Diabetes. 2007;56:574–582
  19. Remakers JD, Plat J, Sebedio JL, Mensink RP. Effects of individual isomers cis-9, trans-11 vs. trans-10, cis-12 of conjugated linoleic acid (CLA) on inflammation parameters in moderately overweight subjects with LDL-phenotype B. Lipids. 2005;40:909–918
  20. Sofi F, Cesari F, Gori AM, Paniccia R, Mannini L, Giorgi G, et al. Lipid, inflammatory, and haemorheological profiles are significantly affected by farmed fish eating: an intervention study.Int J Food Nutr; in press, doi:10.1080/02652040802379399.
  21. Marcucci R, Gori AM, Paniccia R, Giglioli C, Buonamici P, Antoniucci D, et al. Residual platelet reactivity is associated with clinical and laboratory characteristics in patients with ischemic heart disease undergoing PCI on dual antiplatelet therapy. Atherosclerosis. 2007;49:2312–2317

PII: S0939-4753(09)00066-0

doi: 10.1016/j.numecd.2009.03.004

Nutrition, Metabolism & Cardiovascular Diseases
Volume 20, Issue 2 , Pages 117-124 , February 2010

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