Nutrition, Metabolism & Cardiovascular Diseases
Volume 20, Issue 3 , Pages 180-185 , March 2010

Interleukin-20 circulating levels in obese women: Effect of weight loss

  • M.I. Maiorino

      Affiliations

    • Department of Geriatrics and Metabolic Diseases, Division of Metabolic Diseases, Second University of Naples, Piazza L. Miraglia, 80138 Naples, Italy
    • ,
  • B. Schisano

      Affiliations

    • Department of Geriatrics and Metabolic Diseases, Division of Metabolic Diseases, Second University of Naples, Piazza L. Miraglia, 80138 Naples, Italy
    • ,
  • C. Di Palo

      Affiliations

    • Department of Geriatrics and Metabolic Diseases, Division of Metabolic Diseases, Second University of Naples, Piazza L. Miraglia, 80138 Naples, Italy
    • ,
  • M.T. Vietri

      Affiliations

    • Department of General Pathology, Second University of Naples, Piazza L. Miraglia, 80138 Naples, Italy
    • ,
  • M. Cioffi

      Affiliations

    • Department of General Pathology, Second University of Naples, Piazza L. Miraglia, 80138 Naples, Italy
    • ,
  • G. Giugliano

      Affiliations

    • Department of Geriatrics and Metabolic Diseases, Division of Metabolic Diseases, Second University of Naples, Piazza L. Miraglia, 80138 Naples, Italy
    • ,
  • D. Giugliano

      Affiliations

    • Department of Geriatrics and Metabolic Diseases, Division of Metabolic Diseases, Second University of Naples, Piazza L. Miraglia, 80138 Naples, Italy
    • ,
  • K. Esposito

      Affiliations

    • Department of Geriatrics and Metabolic Diseases, Division of Metabolic Diseases, Second University of Naples, Piazza L. Miraglia, 80138 Naples, Italy
    • Corresponding Author InformationCorresponding author. Fax: +39 081 5665054.

Received 22 January 2009 ,Revised 3 March 2009 ,Accepted 6 March 2009.

References 

  1. Flegal KM, Carroll MD, Ogden CL. Prevalence and trend in obesity among US adults, 1999–2000. JAMA. 2002;288:1723–1727
  2. WHO . Obesity: preventing and managing the global epidemic. WHO technical report series number 894 Geneva: WHO; 2000;
  3. James WTP, Rigby N, Leach R. The obesity epidemic, metabolic syndrome and future prevention strategies. Eur J Cardiovasc Prev Rehabil. 2004;11:3–8
  4. Adams KF, Schatzkin A, Harris TB, Kipnis V, Mouw T, Ballard-Barbash R. Overweight, obesity, and mortality in a large prospective cohort of persons 50 to 71 years old. N Engl J Med. 2006;355:763–778
  5. Van Gaal LF, Mertens IL, De Block CE. Mechanisms linking obesity with cardiovascular disease. Nature. 2006;444:875–880
  6. Tedgui A, Mallat Z. Cytokines in atherosclerosis: pathogenic and regulatory pathways. Physiol Rev. 2006;86:515–581
  7. Hsing CH, Ho CL, Chang LY, Lee YL, Chuang SS, Chang MS. Tissue microarray analysis of interleukin-20 expression. Cytokine. 2006;35:44–52
  8. Wei CC, Hsu YH, Li HH, Wang YC, Hsieh MY, Chen WY, et al. IL-20: biological functions and clinical implications. J Biomed Sci. 2006;13:601–612
  9. Chen WY, Cheng BC, Jiang MJ, Hsieh MY, Chang MS. IL-20 is expressed in atherosclerosis plaques and promotes atherosclerosis in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol. 2006;26:2090–2095
  10. Mohamed-Ali V, Goodrick S, Rawesh A, Katz DR, Miles JM, Yudkin JS, et al. Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-α, in vivo. J Clin Endocrinol Metab. 1997;82:4196–4200
  11. Esposito K, Pontillo A, Di Palo C, Giugliano G, Masella M, Marfella R, et al. Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women. JAMA. 2003;289:1799–1804
  12. Bradley RL, Fisher FF, Maratos-Flier E. Dietary fatty acids differentially regulate production of TNF-alpha and IL-10 by murine 3T3-L1 adipocytes. Obesity (Silver Spring). 2008;16:938–944
  13. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412–419
  14. Jung SH, Park HS, Kim KS, Choi WH, Ahn CW, Kim BT, et al. Effect of weight loss on some serum cytokines in human obesity: increase in IL-10 after weight loss. J Nutr Biochem. 2008;19:371–375
  15. Stefan N, Stumvoll M. Adiponectin – its role in metabolism and beyond. Horm Metab Res. 2002;34:469–474
  16. Mallat Z, Heymes C, Ohan J, Faggin E, Lesèche G, Tedgui A. Expression of interleukin-10 in advanced human atherosclerotic plaques: relation to inducible nitric oxide synthase expression and cell death. Arterioscler Thromb Vasc Biol. 1999;19:611–616
  17. Juge-Aubry CE, Somm E, Pernin A, Alizadeh N, Giusti V, Dayer JM, et al. Adipose tissue is a regulated source of interleukin-10. Cytokine. 2005;29:270–274
  18. Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest. 2003;112:1796–1808
  19. Rosen ED, Spiegelman BM. Adipocytes as regulators of energy balance and glucose homeostasis. Nature. 2006;444:847–853
  20. Weisberg SP, Hunter D, Huber R, Lemieux J, Slaymaker S, Vaddi K, et al. CCR2 modulates inflammatory and metabolic effects of high-fat feeding. J Clin Invest. 2006;116:115–124
  21. Kamei N, Tobe K, Suzuki R, Ohsugi M, Watanabe T, Kubota N, et al. Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance. J Biol Chem. 2006;281:26602–26614
  22. Bornstein SR, Abu-Asab M, Glasow A, Päth G, Hauner H, Tsokos M, et al. Immunoistochemical and ultrastructural localization of leptin and leptin receptor in human white adipose tissue and differentiating human adipose cells in primary cultures. Diabetes. 2000;49:532–538
  23. Despres JP, Lemieux I, Prud'homme D. Treatment of obesity: need to focus on high risk abdominally obese patients. Br Med J. 2001;322:716–720
  24. Kuk JL, Katzmarzyk PT, Nichaman MZ, Church TS, Blair SN, Ross R. Visceral fat is an independent predictor of all-cause mortality in men. Obesity. 2006;14:336–342
  25. Li TY, Rana JS, Manson JE, Willett WC, Stampfer MJ, Colditz GA, et al. Obesity as compared with physical activity in predicting risk of coronary heart disease in women. Circulation. 2006;113:499–506
  26. Tenaglia AN, Peters KG, Sketch MH, Annex BH. Neovascularization in atherectomy specimens from patients with unstable angina: implications for pathogenesis of unstable angina. Am Heart J. 1998;135:10–14
  27. Tritsaris K, Myren M, Ditlev SB, Hübschmann MV, van der Blom I, Hansen AJ, et al. IL-20 is an arteriogenic cytokine that remodels collateral networks and improves functions of ischemic hind limbs. Proc Natl Acad Sci U S A. 2007;104:15364–15369
  28. Ridker PM. On evolutionary biology, inflammation, infection, and the causes of atherosclerosis. Circulation. 2002;105:2–4
  29. Esposito K, Giugliano G, Scuderi N, Giugliano D. Role of adipokines in the obesity-inflammation relationship: the effect of fat removal. Plast Reconstr Surg. 2006;118:1048–1057
  30. Giugliano D, Ceriello A, Esposito K. The effects of diet on inflammation: emphasis on the metabolic syndrome. J Am Coll Cardiol. 2006;48:677–685

PII: S0939-4753(09)00067-2

doi: 10.1016/j.numecd.2009.03.006

Nutrition, Metabolism & Cardiovascular Diseases
Volume 20, Issue 3 , Pages 180-185 , March 2010

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