Comparison between several insulin sensitivity indices and metabolic risk factors in overweight and obese postmenopausal women: A MONET study
Received 17 November 2008; accepted 9 March 2009. published online 08 June 2009.
Abstract
Background and aims
The purpose of this study was to compare the relationship of several insulin sensitivity indices with cardiometabolic risk factors in overweight and obese postmenopausal women.
Methods and results
This was a cross-sectional study involving 137 overweight and obese postmenopausal women (age: 57.7±4.8 yrs; body mass index: 32.4±4.6kg/m2; body fat: 38.6±9.2kg). Insulin sensitivity was determined by the euglycaemic–hyperinsulinemic (EH) clamp technique as well as by oral glucose tolerance test (OGTT) derived indices (Stumvoll, Matsuda and SIis) and fasting surrogate indices (HOMA, QUICKI). Cardiometabolic risk factors included: body composition and visceral fat that were measured using dual energy X-ray absorptiometry and computed tomography, respectively. Peak oxygen consumption, lower body muscle strength (using weight training equipment), physical activity energy expenditure (doubly labeled water), plasma lipids and C-reactive protein were also measured. Correlations of insulin sensitivity indices with metabolic risk factors showed some similarities, however, a wide range of variations were also observed. Furthermore, our results showed that visceral fat was the primary predictor for surrogate and OGTT indices, explaining 15–28% of the variance and the triglycerides/HDL-C ratio was the primary predictor for the EH clamp indices, explaining 15–17% of the variance.
Conclusion
The present study indicates that the different methods of measuring and/or expressing insulin sensitivity display variations for associations with cardiometabolic risk factors. Therefore, interpretations of relationships between insulin sensitivity indices and cardiometabolic risk factors should take into account the method used to estimate and express insulin sensitivity.
aDepartment of Nutrition, University of Montreal, Montreal, Quebec, Canada
bCHUM (Centre hospitalier de l'Université de Montréal) Research Center, Montreal, Quebec, Canada
cMDRC (Montreal Diabetes Research Center), Montreal, Quebec, Canada
dDepartment of Kinesiology, University of Montreal, Montreal, Quebec, Canada
eINSERM U680, Faculté de Médecine Saint-Antoine et Service de Biochimie et Hormonologie, AP-HP; Hôpital Tenon, Université Pierre et Marie Curie, Paris, France
fDepartment of Kinanthropology, University of Quebec at Montreal, Case postale 8888, succursale Centre-ville, Montreal, Quebec H3C 3P8, Canada
ABSTRACT