Nutrition, Metabolism & Cardiovascular Diseases
Volume 20, Issue 5 , Pages 308-316 , June 2010

Applicability of non-cholesterol sterols in predicting response in cholesterol metabolism to simvastatin and fluvastatin treatment among hypercholesterolemic men

  • M.J. Nissinen

      Affiliations

    • Department of Medicine, Division of Gastroenterology, University of Helsinki, Helsinki, Finland
    • Corresponding Author InformationCorresponding author. Department of Medicine, Division of Gastroenterology, Biomedicum Helsinki, Room C422, University of Helsinki, P.O. Box 700, FI-00029 Helsinki, Finland. Tel.: +358 50 5268538; fax: +358 9 4717 1851.
    • These authors equally contributed to this work.
  • ,
  • T.E. Miettinen

      Affiliations

    • Department of Medicine, Division of Internal Medicine, University of Helsinki, Helsinki, Finland
    • These authors equally contributed to this work.
  • ,
  • H. Gylling

      Affiliations

    • Department of Clinical Nutrition, University of Kuopio, Finland
    • Department of Medicine, Kuopio University Hospital, Kuopio, Finland
  • ,
  • T.A. Miettinen

      Affiliations

    • Department of Medicine, Division of Internal Medicine, University of Helsinki, Helsinki, Finland

Received 28 December 2008 ,Revised 18 March 2009 ,Accepted 23 April 2009.

References 

  1. Grundy SM, Cleeman JI, Merz CNB, Brewer HB, Clark LT, Hunninghake DB, et al. Coordinating Committee of the National Cholesterol Education Program and Endorsed by the National Heart, Lung, and Blood Institute, American College of Cardiology Foundation, and American Heart Association. Circulation. 2004;110:227–229
  2. Miettinen TA, Gylling H, Strandberg T, Sarna S. Finnish 4S investigators. Baseline serum cholestanol as predictor of recurrent coronary events in subgroup of Scandinavian simvastatin survival study. BMJ. 1998;316:1127–1130
  3. Miettinen TA, Strandberg TE, Gylling H. Finnish investigators of the Scandinavian Simvastatin Survival Study Group. Noncholesterol sterols and cholesterol lowering by long-term simvastatin treatment in coronary patients. Relation to basal serum cholestanol. Arterioscler Thromb Vasc Biol. 2000;20:1340–1346
  4. Miettinen TA, Gylling H. Synthesis and absorption markers of cholesterol in serum and lipoproteins during a large dose of statin treatment. Eur J Clin Invest. 2003;33:976–982
  5. Miettinen TA, Tilvis RS, Kesäniemi YA. Serum cholestanol and plant sterol levels in relation to cholesterol metabolism in middle-aged men. Metabolism. 1989;38:136–140
  6. Miettinen TA, Tilvis RS, Kesäniemi YA. Serum plant sterols and cholesterol precursors reflect cholesterol absorption and synthesis in volunteers of a randomly selected male population. Am J Epidemiol. 1990;131:20–31
  7. Simonen P, Gylling H, Miettinen TA. The validity of serum squalene and non-cholesterol sterols as surrogate markers of cholesterol synthesis and absorption in type 2 diabetes. Atherosclerosis. 2008;197:883–888
  8. Tilvis RS, Miettinen TA. Serum plant sterols and their relation to cholesterol absorption. Am J Clin Nutr. 1986;43:92–97
  9. Nissinen MJ, Gylling H, Miettinen TA. Responses of surrogate markers of cholesterol absorption and synthesis to changes in cholesterol metabolism during various amounts of fat and cholesterol feeding among healthy men. Br J Nutr. 2008;99:370–378
  10. Björkhem I, Miettinen TA, Reihner E, Ewerth S, Angelin B, Einarsson K. Correlation between serum levels of some cholesterol precursors and activity of HMG-CoA reductase in human liver. J Lipid Res. 1987;28:1137–1143
  11. Sigurdsson G, Haraldsdottir SO, Melberg TH, Tikkanen MJ, Miettinen TE, Kristianson KJ. Simvastatin compared to fluvastatin in the reduction of serum lipids and apolipoproteins in patients with ischaemic heart disease and moderate hypercholesterolaemia. Acta Cardiol. 1998;1:7–14
  12. Knuts L-R, Rastas M, Haapala P. Micro-Nutrica. Version 1.0. Helsinki: National Pensions Institute; 1991.
  13. Miettinen TA. Cholesterol metabolism during ketoconazole treatment in man. J Lipid Res. 1988;29:43–51
  14. van de Kamer JH, Bokkel Huinink HT, Weyers HA. Rapid method for the determination of fat in feces. J Biol Chem. 1949;177:347–355
  15. Miettinen TA. Gas–liquid chromatographic determination of fecal neutral sterols using capillary column. Clin Chim Acta. 1982;124:245–248
  16. Bolin DW, King RP, Klosterman EW. A simplified method for the determination of chromic oxide (Cr2O3) when used as an index substance. Science. 1952;116:634–635
  17. Crouse JR, Grundy SM. Evaluation of a continuous isotope feeding method for measurement of cholesterol absorption in man. J Lipid Res. 1979;19:221–232
  18. Lammert F, Wang DQ-H. New insights into the genetic regulation of intestinal cholesterol absorption. Gastroenterology. 2005;129:718–734
  19. Vanstone CA, Jones PJH. Limitations of plasma plant sterols as indicators of cholesterol absorption. Am J Clin Nutr. 2004;79:340–341
  20. Miettinen TA, Gylling H, Lindbohm N, Miettinen TE, Rajaratnam RA, Relas H. Finnish treat-to-target study investigators. Serum noncholesterol sterols during inhibition of cholesterol synthesis by statins. J Lab Clin Med. 2003;141:131–137
  21. Miettinen TA, Gylling H. The effects of statins and sitosterols: benefit or not?. Curr Atheroscler Rep. 2009;11(1):23–27
  22. Gylling H, Miettinen TA. Baseline intestinal absorption and synthesis of cholesterol regulate its response to hypolipidaemic treatments in coronary patients. Atherosclerosis. 2002;160:477–481

PII: S0939-4753(09)00106-9

doi: 10.1016/j.numecd.2009.04.014

Nutrition, Metabolism & Cardiovascular Diseases
Volume 20, Issue 5 , Pages 308-316 , June 2010