Nutrition, Metabolism & Cardiovascular Diseases
Volume 20, Issue 3 , Pages 208-216 , March 2010

Perspectives of nuclear diagnostic imaging in diabetic cardiomyopathy

  • F.C. Sasso

      Affiliations

    • Unit of Internal Medicine, Dept. of Clinical and Experimental Medicine “Magrassi-Lanzara”, Second University of Naples, Naples, Italy
    • Excellence Centre for Cardiovascular Disease, Second University of Naples, Italy
    • Corresponding Author InformationCorresponding author. Unit of Internal Medicine, Dept. of Clinical and Experimental Medicine “Magrassi-Lanzara”, Excellence Centre for Cardiovascular Disease, Second University of Naples, Via F. Petrarca, 64, I-80122 Naples, Italy. Tel.: +39 081 5666707; fax: +39 081 5666736.
    • ,
  • P.F. Rambaldi

      Affiliations

    • Nuclear Medicine, Dept. of Clinical and Experimental Medicine “Magrassi-Lanzara”, Second University of Naples, Italy
    • Excellence Centre for Cardiovascular Disease, Second University of Naples, Italy
    • ,
  • O. Carbonara

      Affiliations

    • Unit of Internal Medicine, Dept. of Clinical and Experimental Medicine “Magrassi-Lanzara”, Second University of Naples, Naples, Italy
    • Excellence Centre for Cardiovascular Disease, Second University of Naples, Italy
    • ,
  • R. Nasti

      Affiliations

    • Unit of Internal Medicine, Dept. of Clinical and Experimental Medicine “Magrassi-Lanzara”, Second University of Naples, Naples, Italy
    • Excellence Centre for Cardiovascular Disease, Second University of Naples, Italy
    • ,
  • M. Torella

      Affiliations

    • Cardiac Surgery, Second University of Naples, Italy
    • ,
  • A. Rotondo

      Affiliations

    • Nuclear Medicine, Dept. of Clinical and Experimental Medicine “Magrassi-Lanzara”, Second University of Naples, Italy
    • Excellence Centre for Cardiovascular Disease, Second University of Naples, Italy
    • ,
  • R. Torella

      Affiliations

    • Unit of Internal Medicine, Dept. of Clinical and Experimental Medicine “Magrassi-Lanzara”, Second University of Naples, Naples, Italy
    • Excellence Centre for Cardiovascular Disease, Second University of Naples, Italy
    • ,
  • L. Mansi

      Affiliations

    • Nuclear Medicine, Dept. of Clinical and Experimental Medicine “Magrassi-Lanzara”, Second University of Naples, Italy
    • Excellence Centre for Cardiovascular Disease, Second University of Naples, Italy

Received 19 March 2009 ,Revised 23 July 2009 ,Accepted 31 August 2009.

References 

  1. Hamby RI, Zoneraich S, Sherman L. Diabetic cardiomyopathy. JAMA. 1974;229:1749–1754
  2. Joffe II, Travers KE, Perreault-Micale CL, Hampton T, Katz SE, Morgan JP, et al. Abnormal cardiac function in the streptozotocin-induced non-insulin-dependent diabetic rat: noninvasive assessment with Doppler echocardiography and contribution of the nitric oxide pathway. J Am Coll Cardiol. 1999;34:2111–2119
  3. Sohn DW, Chai IH, Lee DJ, Kim HC, Kim HS, Oh BH, et al. Assessment of mitral annulus velocity by Doppler tissue imaging in the evaluation of left ventricular diastolic function. J Am Coll Cardiol. 1997;30:474–480
  4. Rodrigues B, Cam MC, McNeill JH. Metabolic disturbances in diabetic cardiomyopathy. Mol Cell Biochem. 1998;180:53–57
  5. Frustaci A, Kajstura J, Chimenti C, Jakoniuk I, Leri A, Maseri A, et al. Myocardial cell death in human diabetes. Circ Res. 2000;87:1123–1132
  6. Kawaguchi M, Techigawara M, Ishihata T, Asakura T, Saito F, Maehara K, et al. A comparison of ultrastructural changes on endomyocardial biopsy specimens obtained from patients with diabetes mellitus with and without hypertension. Heart Vessels. 1997;12:267–274
  7. Brooks BA, Franjic B, Ban CR, Swaraj K, Yue DK, Celermajer DS, et al. Diastolic dysfunction and abnormalities of the microcirculation in type 2 diabetes. Diabetes Obes Metab. 2008 September;10(9):739–746
  8. Takahashi N, Nakagawa M, Saikawa T, Ooie T, Yufu K, Shigematsu S, et al. Effect of essential hypertension on cardiac autonomic function in type 2 diabetic patients. J Am Coll Cardiol. 2001;38:232–237
  9. Dutta K, Podolin DA, Davidson MB, Davidoff AJ. Cardiomyocyte dysfunction in sucrose-fed rats is associated with insulin resistance. Diabetes. 2001;50:1186–1192
  10. Lopaschuk GD, Collins-Nakai RL, Itoi T. Developmental changes in energy substrate use by the heart. Cardiovasc Res. 1992;26:1172–1180
  11. Ferrannini E, Santoro D, Bonadonna R, Natali A, Parodi O, Camici PG. Metabolic and hemodynamic effects of insulin on human hearts. Am J Phys. 1993;264:E308–E315
  12. Camici P, Marraccini P, Marzilli M, Lorenzoni R, Buzzigoli G, Puntoni R, et al. Coronary hemodynamics and myocardial metabolism during and after pacing stress in normal humans. Am J Phys. 1989;257:E309–E317
  13. Sasso FC, Carbonara O, Cozzolino D, Rambaldi P, Mansi L, Torella D, et al. Effects of insulin-glucose infusion on left ventricular function at rest and during dynamic exercise in healthy subjects and noninsulin dependent diabetic patients. J Am Coll Cardiol. 2000;36:219–226
  14. Sasso FC, Carbonara O, Nasti R, Marfella R, Esposito K, Rambaldi P, et al. Effects of insulin on left ventricular function during dynamic exercise in overweight and obese subjects. Eur Heart J. 2005;26:1205–1212
  15. Nuutila P, Knuuti J, Ruotsalainen U, Koivisto VA, Eronen E, Teras M, et al. Insulin resistance is localized to skeletal but not heart muscle in type 1 diabetes. Am J Phys. 1993;264:E756–E762
  16. Voipio-Pulkki LM, Nuutila P, Knuuti MJ, Ruotsalainen U, Haaparanta M, Teras M, et al. Heart and skeletal muscle glucose disposal in type-2 diabetic patients as determined by positron emission tomography. J Nucl Med. 1993;34:2064–2067
  17. Young LH, Zaret BL, Barrett EJ. Physiologic hyperinsulinemia stimulates lactate extraction by heart muscle in the conscious dog. Metab Clin Exp. 1989;38:1115–1119
  18. Galderisi M. Diastolic dysfunction and diabetic cardiomyopathy: evaluation by Doppler echocardiography. J Am Coll Cardiol. 2006 October 17;48(8):1548–1551
  19. Pattoneri P, Sozzi FB, Catellani E, Piazza A, Iotti R, Michelini M, et al. Myocardial involvement during the early course of type 2 diabetes mellitus: usefulness of myocardial performance index. Cardiovasc Ultrasound. 2008 June 5;6:27
  20. Iskander S, Iskandrian AE. Risk assessment using single-photon emission computed tomographic technetium-99m sestamibi imaging. J Am Coll Cardiol. 1998;32:57–62
  21. Hachamovitch R, Berman DS, Shaw LJ, Kiat H, Cohen I, Cabico JA, et al. Incremental prognostic value of myocardial perfusion single photon emission computed tomography for the prediction of cardiac death: differential stratification for risk of cardiac death and myocardial infarction. Circulation. 1998;97:535–543
  22. Hachamovitch R, Berman DS, Kiat H, Cohen I, Friedman JD, Shaw LJ. Value of stress myocardial perfusion single photon emission computed tomography in patients with normal resting electrocardiograms: an evaluation of incremental prognostic value and cost-effectiveness. Circulation. 2002;105:823–829
  23. Shaw LJ, Hachamovitch R, Berman DS, Marwick TH, Lauer MS, Heller GV, et al. The economic consequences of available diagnostic and prognostic strategies for the evaluation of stable angina patients: an observational assessment of the value of precatheterization ischemia. Economics of Noninvasive Diagnosis (END) Multicenter Study Group. J Am Coll Cardiol. 1999;33:661–669
  24. Brown KA, Heller GV, Landin RS, Shaw LJ, Beller GA, Pasquale MJ, et al. Early dipyridamole (99m) Tc-sestamibi single photon emission computed tomographic imaging 2 to 4 days after acute myocardial infarction predicts in-hospital and postdischarge cardiac events: comparison with submaximal exercise imaging. Circulation. 1999;100:2060–2066
  25. Wackers FJ, Zaret BL. Detection of myocardial ischemia in patients with diabetes mellitus. Circulation. 2002;105:5–7
  26. Ritchie JL, Bateman TM, Bonow RO, Crawford MH, Gibbons RJ, Hall RJ, et al. ACC/AHA Task Force report. Guidelines for clinical use of cardiac radionuclide imaging. Report of the American College of Cardiology/American Heart Association Task Force on assessment of diagnostic and therapeutic cardiovascular procedures (Committee on Radionuclide Imaging): developed in collaboration with the American Society of Nuclear Cardiology. J Am Coll Cardiol. 1995;25:521–547
  27. Kang X, Berman DS, Lewin H, Miranda R, Erel J, Friedman JD, et al. Comparative ability of myocardial perfusion single-photon emission computed tomography to detect coronary artery disease in patients with and without diabetes mellitus. Am Heart J. 1999;137:949–957
  28. Kang X, Berman DS, Lewin HC, Cohen I, Friedman JD, Germano G, et al. Incremental prognostic value of myocardial perfusion single photon emission computed tomography in patients with diabetes mellitus. Am Heart J. 1999;138:1025–1032
  29. Sharir T, Germano G, Kavanagh PB, Lai S, Cohen I, Lewin HC, et al. Incremental prognostic value of post-stress left ventricular ejection fraction and volume by gated myocardial perfusion single-photon emission computed tomography. Circulation. 1999;100:1035–1042
  30. Berman DS, Hachamovitch R, Kiat H, Cohen I, Cabico JA, Wang FP, et al. Incremental value of prognostic testing in patients with known or suspected ischemic heart disease: a basis for optimal utilization of exercise technetium-99m sestamibi myocardial perfusion single-photon emission computed tomography. J Am Coll Cardiol. 1995;26:639–647
  31. Germano G, Kiat H, Kavanagh PB, Moriel M, Mazzanti M, Su HT, et al. Automatic quantification of ejection fraction from gated myocardial perfusion SPECT. J Nucl Med. 1995;36:2138–2147
  32. Germano G, Erel J, Lewin H, Kavanagh PB, Berman DS. Automatic quantitation of regional myocardial wall motion and thickening from gated technetium-99m sestamibi myocardial perfusion single-photon emission computed tomography. J Am Coll Cardiol. 1997;30:1360–1367
  33. Akincioglu C, Berman DS, Nishina H, Kavanagh PB, Slomka PJ, Abidov A, et al. Assessment of diastolic function using 16-frame 99mTc-sestamibi gated myocardial perfusion SPECT: normal values. J Nucl Med. 2005;46:1102–1108
  34. Danias PG, Papaioannou GI, Ahlberg AW, O'Sullivan DM, Mann A, Boden WE, et al. Usefulness of electrocardiographic-gated stress technetium-99-m sestamibi single photon emission computed tomography to differentiate ischemic from non ischemic cardiomyopathy. Am J Cardiol. 2004;94:14–19
  35. Spadafora M, Manganelli F, Rosato G. Simultaneous quantitative assessment of myocardial perfusion and left ventricular function for detecting ischemic and nonischemic dilated cardiomyopathy. Eur J Nucl Med Mol Imaging. 2004;31(Suppl. 2):308
  36. The TIMI Study Group. The Thrombolysis in Myocardial Infarction (TIMI) trial. Phase I findings. N Engl J Med. 1985;312:932–936
  37. Gibson CM, Cannon CP, Murphy SA, Marble SJ, Barron HV, Braunwald E TIMI Study Group. Relationship of the TIMI myocardial perfusion grades, flow grades, frame count, and percutaneous coronary intervention to long-term outcomes after thrombolytic administration in acute myocardial infarction. Circulation. 2002;105:1909–1913
  38. Angeja BG, Gunda M, Murphy SA, Sobel BE, Rundle AC, Syed M, et al. TIMI myocardial perfusion grade and ST segment resolution: association with infarct size as assessed by single photon emission computed tomography imaging. Circulation. 2002;105:282–285
  39. Di Carli MF, Hachamovitch R. Should we screen for occult coronary artery disease among asymptomatic patients with diabetes?. J Am Coll Cardiol. 2005;45:50–53
  40. American Diabetes Association . Consensus development conference on the diagnosis of coronary heart disease in people with diabetes. Diabetes Care. 1998;21:1551–1559
  41. Quiñones MJ, Hernandez-Pampaloni M, Schelbert H, Bulnes-Enriquez I, Jimenex X, Hernandez G, et al. Coronary vasomotor abnormalities in insulin-resistant individuals. Ann Intern Med. 2004;140(9):700–708
  42. Prior JO, Quiñones MJ, Hernandez-Pampaloni M, Facta AD, Schindler TH, Sayre JW, et al. Coronary circulatory dysfunction in insulin resistance, impaired glucose tolerance, and type 2 diabetes mellitus. Circulation. 2005;111(18):2291–2298
  43. Sawada S, Hamoui O, Barclay J, Giger S, Fain R, Foltz J, et al. Usefulness of positron emission tomography in predicting long-term outcome in patients with diabetes mellitus and ischemic left ventricular dysfunction. Am J Cardiol. 2005;96:2–8
  44. Brown TL, Merrill J, Volokh L, Bengel FM. Determinants of the response of left ventricular ejection fraction to vasodilator stress in electrocardiographically gated (82)rubidium myocardial perfusion PET. Eur J Nucl Med Mol Imaging. 2008;35:336–342
  45. Schinkel AF, Poldermans D, Rizzello V, van Domburg RT, Valmeka R, Elhendy A, et al. Impact of diabetes mellitus on prediction of clinical outcome after coronary revascularization by 18F-FDG SPECT in patients with ischemic left ventricular dysfunction. J Nucl Med. 2006 January;47(1):66–73
  46. Schinkel AF, Bax JJ, Valkema R, Elhendy A, van Domburg RT, Vourvouri EC, et al. Effect of diabetes mellitus on myocardial 18F-FDG SPECT using acipimox for the assessment of myocardial viability. J Nucl Med. 2003 June;44(6):877–883
  47. Vitale GD, deKemp RA, Ruddy TD, Williams K, Beanlands RS. Myocardial glucose utilization and optimization of 18F-FDG PET imaging in patients with non-insulin dependent diabetes mellitus, coronary artery disease, and left ventricular dysfunction. J Nucl Med. 2001;42:1730–1736
  48. Herrero P, Peterson LR, McGill JB, Matthew S, Lesniak D, Dence C, et al. Increased myocardial fatty acid metabolism in patients with type 1 diabetes mellitus. J Am Coll Cardiol. 2006;47:598–604
  49. O'Brien IA, McFadden JP, Corrall RJM. The influence of autonomic neuropathy on mortality in insulin-dependent diabetes. Q J Med. 1991;79:495–502
  50. Chen HS, Hwu CM, Kuo BI, Chiang SC, Kwok CF, Lee SH, et al. Abnormal cardiovascular reflex tests are predictors of mortality in type 2 diabetes mellitus. Diabet Med. 2001;18:268–273
  51. Gerritsen J, Dekker JM, TenVoorde BJ, Kostense PJ, Heine RJ, Bouter LM, et al. Impaired autonomic function is associated with increased mortality, especially in subjects with diabetes, hypertension, or a history of cardiovascular disease: the Hoorn Study. Diabetes Care. 2001;24:1793–1798
  52. Scognamiglio R, Avogaro A, Casara D, Crepaldi C, Marin M, Palisi M, et al. Myocardial dysfunction and adrenergic cardiac innervation in patients with insulin-dependent diabetes mellitus. J Am Coll Cardiol. 1998;31:404–412
  53. Grassi G, Esler M. How to assess sympathetic activity in humans. J Hypertens. 1999;17:719–734
  54. Stevens MJ, Dayanikli F, Raffel DM, Allman KC, Sandford T, Feldman EL, et al. Scintigraphic assessment of regionalized defects in myocardial sympathetic innervation and blood flow regulation in diabetic patients with autonomic neuropathy. J Am Coll Cardiol. 1998;31:1575–1584
  55. Lange A, Freeman MR, Josse RG, Armstrong PW. Metaiodobenzylguanidine imaging in diabetes mellitus: assessment of cardiac sympathetic denervation and its relation to autonomic dysfunction and silent myocardial ischemia. J Am Coll Cardiol. 1995;25:610–618
  56. Schnell O, Kirsch CM, Stemplinger J, Haslbeck M, Standl E. Scintigraphic evidence for cardiac sympathetic dysinnervation in long-term IDDM patients with and without ECG-based autonomic neuropathy. Diabetologia. 1995;38:1345–1352
  57. Patel AD, Iskandrian AE. MIBG imaging. J Nucl Cardiol. 2002;9:75–92
  58. Diakakis GF, Parthenakis FI, Patrianakos AP, Koukouraki SI, Stathaki MI, Karkavitsas NS, et al. Myocardial sympathetic innervation in patients with impaired glucose tolerance: relationship to subclinical inflammation. Cardiovasc Pathol. 2008;17:172–177
  59. Haldeman GA, Croft JB, Giles WH, Rashidee A. Hospitalization of patients with heart failure: National Hospital Discharge Survey, 1985 to 1995. Am Heart J. 1999;137:352–360
  60. Arora R, Ferrick KJ, Nakata T, Kaplan RC, Rozengarten M, Latif F, et al. I-123 MIBG imaging and heart rate variability analysis to predict the need for an implantable cardioverter defibrillator. J Nucl Cardiol. 2003;10:121–131
  61. ICRP Publication 80 Radiation dose to patients from radiopharmaceuticals. Ann ICRP. 1998;28(3):Pergamon Press, Oxford
  62. Effects of ionizing radiation. vol. 1–2. UN Scientific Committee on the Effect of Atomic Radiation. UNSCEAR; 2006;Official Records of the UN General Assembly, 61 session, supplement n°46, 2008
  63. ACCF/ASNC/ACR/AHA/ASE/SCCT/SCMR/SNM 2009 . Appropriate use criteria for cardiac radionuclide imaging. J Am Coll Cardiol. 2009;53(23):2201–2229
  64. Young LH, Wackers FJT, Chyun DA, Davey JA, Barrett EJ, Taillfer R, et al. for the DIAD Investigators Cardiac outcomes after screening for asymptomatic coronary artery disease in patients with type 2 diabetes. JAMA. 2009;301(15):1547–1555

PII: S0939-4753(09)00212-9

doi: 10.1016/j.numecd.2009.08.013

Nutrition, Metabolism & Cardiovascular Diseases
Volume 20, Issue 3 , Pages 208-216 , March 2010

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