Nutrition, Metabolism & Cardiovascular Diseases
Volume 21, Issue 3 , Pages 182-188 , March 2011

Non-cholesterol sterols in serum and endarterectomized carotid arteries after a short-term plant stanol and sterol ester challenge

  • T.A. Miettinen

      Affiliations

    • Department of Medicine, Division of Internal Medicine, University of Helsinki, Helsinki, Finland
    • Corresponding Author InformationCorresponding author at: Biomedicum Helsinki C 4 22, P.O. BOX 700, FIN-00029 HUS, Finland. Fax: +358 9 47171851.
    • ,
  • M. Nissinen

      Affiliations

    • Department of Medicine, Division of Gastroenterology, University of Helsinki, Helsinki, Finland
    • ,
  • M. Lepäntalo

      Affiliations

    • Department of Surgery, Division of Vascular Surgery, Helsinki University Central Hospital, Helsinki, Finland
    • ,
  • A. Albäck

      Affiliations

    • Department of Surgery, Division of Vascular Surgery, Helsinki University Central Hospital, Helsinki, Finland
    • ,
  • M. Railo

      Affiliations

    • Department of Surgery, Division of Vascular Surgery, Helsinki University Central Hospital, Helsinki, Finland
    • ,
  • P. Vikatmaa

      Affiliations

    • Department of Surgery, Division of Vascular Surgery, Helsinki University Central Hospital, Helsinki, Finland
    • ,
  • M. Kaste

      Affiliations

    • Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland
    • ,
  • S. Mustanoja

      Affiliations

    • Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland
    • ,
  • H. Gylling

      Affiliations

    • Department of Clinical Nutrition, University of Kuopio, Kuopio, Finland
    • Department of Medicine, Kuopio University Hospital, Kuopio, Finland

Received 3 June 2009 ,Revised 9 September 2009 ,Accepted 10 September 2009.

References 

  1. MRC/BHF . Heart Protection Study of cholesterol lowering with simvastatin in 20536 high-risk individuals: a randomised placebo-controlled trial. Lancet. 2002;360:7–22
  2. Miettinen TA. Detection of changes in human cholesterol metabolism. Ann Clin Res. 1970;2:300–320
  3. Miettinen TA, Tilvis RS, Kesaniemi YA. Serum plant sterols and cholesterol precursors reflect cholesterol absorption and synthesis in volunteers of a randomly selected male population. Am J Epidemiol. 1990;131:20–31
  4. Simonen P, Gylling H, Miettinen TA. The validity of serum squalene and non-cholesterol sterols as surrogate markers of cholesterol synthesis and absorption in type 2 diabetes. Atherosclerosis. 2008;197:883–888
  5. Miettinen TA, Tilvis RS, Kesäniemi YA. Serum cholestanol and plant sterol levels in relation to cholesterol metabolism in middle-aged men. Metabolism. 1989;38:136–140
  6. Miettinen TA, Railo M, Lepäntalo M, Gylling H. Plant sterols in serum and in atherosclerotic plaques of patients undergoing carotid endarterectomy. J Am Coll Cardiol. 2005;45:1792–1801
  7. Helske S, Miettinen T, Gylling H, Mäyränpää M, Lommi J, Turto H, et al. Accumulation of cholesterol precursors and plant sterols in human stenotic aortic valves. J Lipid Res. 2008;49:1511–1518
  8. Weingärtner O, Lütjohann D, Ji S, Weisshoff N, List F, Sudhop T, et al. Vascular effects of diet supplementation with plant sterols. J Am Coll Cardiol. 2008;51:1553–1561
  9. NASCET (North American Symptomatic Carotis Endarterectomy Trial) Collaborators. N Engl J Med. 1991;325:445–453
  10. Miettinen TA. Cholesterol metabolism during ketoconazole treatment in man. J Lipid Res. 1988;29:43–51
  11. Ostlund RE, McGill JB, Zeng CM, Covey DF, Stearns J, Stenson WF, et al. Gastrointestinal absorption and plasma kinetics of soy δ5-phytosterols and phytostanols in humans. Am J Physiol Endocrinol Metab. 2002;282:E911–E916
  12. Wilund KR, Yu L, Xu F, Vega GL, Grundy SM, Cohen JC, et al. No association between plasma levels of plant sterols and atherosclerosis in mice and men. Arterioscler Thromb Vasc Biol. 2004;24:2326–2332
  13. Assmann G, Cullen P, Erbey J, Ramey DR, Kannenberg F, Schulte H. Plasma sitosterol elevations are associated with an increased incidence of coronary events in men: results of a nested case-control analysis of the Prospective Cardiovascular Münster (PROCAM) study. Nutr Metab Cardiovasc Dis. 2006;16:13–21
  14. Pinedo S, Vissers MN, von Bergmann K, Elharchaoui K, Lütjohann D, Luben R, et al. Plasma levels of plant sterols and the risk of coronary artery disease: the prospective EPIC-Norfolk Population Study. J Lipid Res. 2007;48:139–144
  15. Miettinen TA, Gylling H. Synthesis and absorption markers of cholesterol in serum and lipoproteins during a large dose of statin treatment. Eur J Clin Invest. 2003;33:976–982
  16. van Himbergen TM, Matthan NR, Resteghini NA, Otokozawa S, Ai M, Stein EA, et al. Comparison of the effects of maximal dose atorvastatin and rosuvastatin therapy on cholesterol synthesis and absorption markers. J Lipid Res. 2009;50:730–739
  17. Goldstein MR, Mascitelli L, Pezzetta F. Statins, plant sterol absorption, and increased coronary risk. J Clin Lipidol. 2008;2:304–305
  18. Patel SB. Counterpoint: sorting wheat from chaff. J Clin Lipidol. 2008;2:306–307
  19. Miettinen TA, Gylling H, Strandberg T, Sarna S. Baseline serum cholestanol as predictor of recurrent coronary events in subgroup of Scandinavian simvastatin survival study. BMJ. 1998;316:1127–1130
  20. Miettinen TA, Vuoristo M, Nissinen M, Järvinen HJ, Gylling H. Serum, biliary, and fecal cholesterol and plant sterols in colectomized patients before and during consumption of stanol ester margarine. Am J Clin Nutr. 2000;71:1095–1102

PII: S0939-4753(09)00219-1

doi: 10.1016/j.numecd.2009.09.006

Nutrition, Metabolism & Cardiovascular Diseases
Volume 21, Issue 3 , Pages 182-188 , March 2011

Article Tools

* Image Usage & Resolution