Glomerular filtration rate, albuminuria and risk of cardiovascular and all-cause mortality in type 2 diabetic individuals

Targher, G.; Zoppini, G.; Chonchol, M.; Negri, C.; Stoico, V.; Perrone, F.; Muggeo, M.; Bonora, E.

doi:10.1016/j.numecd.2009.10.002

« Previous Next »Nutrition, Metabolism & Cardiovascular Diseases
Volume 21, Issue 4 , Pages 294-301, April 2011

Glomerular filtration rate, albuminuria and risk of cardiovascular and all-cause mortality in type 2 diabetic individuals

G. Targher
- Section of Endocrinology, Department of Biomedical and Surgical Sciences, University of Verona, Ospedale Civile Maggiore, Piazzale Stefani, 1 - 37126 Verona, Italy
- Corresponding author. Tel.: +39 045 8123748; fax: +39 045 8027314.
G. Zoppini
- Section of Endocrinology, Department of Biomedical and Surgical Sciences, University of Verona, Ospedale Civile Maggiore, Piazzale Stefani, 1 - 37126 Verona, Italy
M. Chonchol
- Division of Renal Diseases and Hypertension, University of Colorado Denver Health Sciences Center, Denver, CO, USA
C. Negri
- Section of Endocrinology, Department of Biomedical and Surgical Sciences, University of Verona, Ospedale Civile Maggiore, Piazzale Stefani, 1 - 37126 Verona, Italy
V. Stoico
- Section of Endocrinology, Department of Biomedical and Surgical Sciences, University of Verona, Ospedale Civile Maggiore, Piazzale Stefani, 1 - 37126 Verona, Italy
F. Perrone
- Section of Endocrinology, Department of Biomedical and Surgical Sciences, University of Verona, Ospedale Civile Maggiore, Piazzale Stefani, 1 - 37126 Verona, Italy
M. Muggeo
- Section of Endocrinology, Department of Biomedical and Surgical Sciences, University of Verona, Ospedale Civile Maggiore, Piazzale Stefani, 1 - 37126 Verona, Italy
E. Bonora
- Section of Endocrinology, Department of Biomedical and Surgical Sciences, University of Verona, Ospedale Civile Maggiore, Piazzale Stefani, 1 - 37126 Verona, Italy

Received 5 June 2009; received in revised form 3 September 2009; accepted 5 October 2009. published online 22 January 2010.

Abstract

Background and aims

To assess all-cause and cardiovascular mortality in type 2 diabetic individuals according to estimated glomerular filtration rate (eGFR) and albuminuria.

Methods and results

We followed 2823 type 2 diabetic outpatients for a median period of 6 years for the occurrence of all-cause and cardiovascular mortality. eGFR was estimated using the abbreviated Modification of Diet in Renal Disease study equation. At baseline, an eGFR <60ml/min/1.73m² and abnormal albuminuria were present in 22.5% and 26.0% of participants, respectively. During follow-up, a total of 309 patients died, 53% of deaths were secondary to cardiovascular causes. Risks of all-cause and cardiovascular mortality increased progressively with decreasing eGFR and increasing albuminuria. After adjustment for age, sex, body mass index, smoking, hypertension, diabetes duration, hemoglobin A1c, plasma lipids, medications use (hypoglycemic, anti-hypertensive, anti-platelet or lipid-lowering drugs) and albuminuria, the hazard ratios of all-cause and cardiovascular mortality per 1-SD decrease in eGFR were 1.53 (95%CI 1.2–2.0; p<0.0001) and 1.51 (95%CI 1.05–2.2; p=0.023), respectively. A similar pattern in the risk of all-cause and cardiovascular mortality was seen for albuminuria (1.14, 1.01–1.3, p=0.028 and 1.19, 1.01–1.4, p=0.043 per 1-SD increase in albuminuria, respectively) after adjustment for eGFR and other potential confounders.

Conclusions

These findings suggest that both decreasing eGFR and rising albuminuria are associated with all-cause and cardiovascular mortality in type 2 diabetic individuals, independently of traditional risk factors and diabetes-related variables.

Keywords: Chronic kidney disease, Albuminuria, Mortality, Epidemiology, Type 2 diabetes