Nutrition, Metabolism & Cardiovascular Diseases
Volume 21, Issue 4 , Pages 294-301 , April 2011

Glomerular filtration rate, albuminuria and risk of cardiovascular and all-cause mortality in type 2 diabetic individuals

  • G. Targher

      Affiliations

    • Section of Endocrinology, Department of Biomedical and Surgical Sciences, University of Verona, Ospedale Civile Maggiore, Piazzale Stefani, 1 - 37126 Verona, Italy
    • Corresponding Author InformationCorresponding author. Tel.: +39 045 8123748; fax: +39 045 8027314.
    • ,
  • G. Zoppini

      Affiliations

    • Section of Endocrinology, Department of Biomedical and Surgical Sciences, University of Verona, Ospedale Civile Maggiore, Piazzale Stefani, 1 - 37126 Verona, Italy
    • ,
  • M. Chonchol

      Affiliations

    • Division of Renal Diseases and Hypertension, University of Colorado Denver Health Sciences Center, Denver, CO, USA
    • ,
  • C. Negri

      Affiliations

    • Section of Endocrinology, Department of Biomedical and Surgical Sciences, University of Verona, Ospedale Civile Maggiore, Piazzale Stefani, 1 - 37126 Verona, Italy
    • ,
  • V. Stoico

      Affiliations

    • Section of Endocrinology, Department of Biomedical and Surgical Sciences, University of Verona, Ospedale Civile Maggiore, Piazzale Stefani, 1 - 37126 Verona, Italy
    • ,
  • F. Perrone

      Affiliations

    • Section of Endocrinology, Department of Biomedical and Surgical Sciences, University of Verona, Ospedale Civile Maggiore, Piazzale Stefani, 1 - 37126 Verona, Italy
    • ,
  • M. Muggeo

      Affiliations

    • Section of Endocrinology, Department of Biomedical and Surgical Sciences, University of Verona, Ospedale Civile Maggiore, Piazzale Stefani, 1 - 37126 Verona, Italy
    • ,
  • E. Bonora

      Affiliations

    • Section of Endocrinology, Department of Biomedical and Surgical Sciences, University of Verona, Ospedale Civile Maggiore, Piazzale Stefani, 1 - 37126 Verona, Italy

Received 5 June 2009 ,Revised 3 September 2009 ,Accepted 5 October 2009.

References 

  1. Muntner P, He J, Hamm L, Loria C, Whelton PK. Renal insufficiency and subsequent death resulting from cardiovascular disease in the United States. J Am Soc Nephrol. 2002;13:745–753
  2. Go AS, Chertow GM, Fan D, McCulloch CE, Hsu CY. Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med. 2004;351:1296–1305
  3. Manjunath G, Tighiouart H, Ibrahim H, MacLeod B, Salem DN, Griffith JL, et al. Level of kidney function as a risk factor for atherosclerotic cardiovascular outcomes in the community. J Am Coll Cardiol. 2003;41:47–55
  4. Weiner DE, Tighiouart H, Amin MG, Stark PC, MacLeod B, Griffith JL, et al. Chronic kidney disease as a risk factor for cardiovascular disease and all-cause mortality: a pooled analysis of community-based studies. J Am Soc Nephrol. 2004;15:1307–1315
  5. Rifkin DE, Shlipak MG, Katz R, Fried LF, Siscovick D, Chonchol M, et al. Rapid kidney function decline and mortality risk in older adults. Arch Intern Med. 2008;168:2212–2218
  6. van Domburg RT, Hoeks SE, Welten GM, Chonchol M, Elhendy A, Poldermans D. Renal insufficiency and mortality in patients with known or suspected coronary artery disease. J Am Soc Nephrol. 2008;19:158–163
  7. Rossing P. Prediction, progression and prevention of diabetic nephropathy. The Minkowski lecture 2005. Diabetologia. 2006;49:11–19
  8. Nag S, Bilous R, Kelly W, Jones S, Roper N, Connolly V. All-cause and cardiovascular mortality in diabetic subjects increases significantly with reduced estimated glomerular filtration rate (eGFR): 10 years'data from the South Tees diabetes mortality study. Diabet Med. 2007;24:10–17
  9. Gerstein HC, Mann JF, Yi Q, Zinman B, Dinneen SF, Hoogwerf B, et al. HOPE Study Investigators. Albuminuria and risk of cardiovascular events, death, and heart failure in diabetic and nondiabetic individuals. JAMA. 2001;286:421–426
  10. Hillege HL, Fidler V, Diercks GF, Van Glist WH, de Zeeuw D, Van Veldhuisen DJ, et al. Prevention of Renal and Vascular End Stage Disease (PREVEND) study group. Urinary albumin excretion predicts cardiovascular and non-cardiovascular mortality in general population. Circulation. 2002;106:1777–1782
  11. de Zeeuw D. Renal disease: a common and a silent killer. Nat Clin Pract Cardiovasc Med. 2008;1(5 Suppl.):S27–S35
  12. Stiegler H, Standl E, Schulz K, Roth R, Lehmacher W. Morbidity, mortality, and albuminuria in type 2 diabetic patients: a three-year prospective study of a random cohort in general practice. Diabet Med. 1992;9:646–653
  13. Mattock MB, Morrish NJ, Viberti G, Keen H, Fitzgerald AP, Jackson G. Prospective study of microalbuminuria as predictor of mortality in NIDDM. Diabetes. 1992;41:736–741
  14. Gall MA, Borch-Johnsen K, Hougaard P, Nielsen FS, Parving HH. Albuminuria and poor glycemic control predict mortality in NIDDM. Diabetes. 1995;44:1303–1309
  15. Dinneen SF, Gerstein HC. The association of microalbuminuria and mortality in non–insulin-dependent diabetes mellitus: a systematic overview of the literature. Arch Intern Med. 1997;157:1413–1418
  16. Stephenson JM, Kenny S, Stevens LK, Fuller JH, Lee E. Proteinuria and mortality in diabetes: the WHO multinational study of vascular disease in diabetes. Diabet Med. 1995;12:149–155
  17. Valmadrid CT, Klein R, Moss SE, Klein BE. The risk of cardiovascular disease mortality associated with microalbuminuria and gross proteinuria in persons with older-onset diabetes mellitus. Arch Intern Med. 2000;160:1093–1100
  18. Bo S, Ciccone G, Gancia R, Rosato R, Grassi G, Merletti F, et al. Mortality within the first 10 years of the disease in type 2 diabetic patients. Nutr Metab Cardiovasc Dis. 2006;16:8–12
  19. Hallan S, Astor B, Romundstad S, Aasarod K, Kvenild K, Coresh J. Association of kidney function and albuminuria with cardiovascular mortality in older vs. younger individuals. The Hunt II study. Arch Intern Med. 2007;167:2490–2496
  20. So WY, Kong AP, Ma RC, Ozaki R, Szeto CC, Chan NN, et al. Glomerular filtration rate, cardiorenal endpoints, and all-cause mortality in type 2 diabetic patients. Diabetes Care. 2006;29:2046–2052
  21. Bruno G, Merletti F, Bargero G, Novelli G, Melis D, Soddu A, et al. Estimated glomerular filtration rate, albuminuria and mortality in type 2 diabetes: the Casale Monferrato study. Diabetologia. 2007;50:941–948
  22. DAI Study Group . The prevalence of coronary heart disease in type 2 diabetic patients in Italy: the DAI study. Diabet Med. 2004;21:738–745
  23. Comaschi M, Coscelli C, Cucinotta D, Malini P, Manzato E, Nicolucci A SFIDA Study Group -Italian Association of Diabetologists (AMD). Cardiovascular risk factors and metabolic control in type 2 diabetic subjects attending outpatient clinics in Italy: the SFIDA (survey of risk factors in Italian diabetic subjects by AMD) study. Nutr Metab Cardiovasc Dis. 2005;15:204–211
  24. Avogaro A, Guida P, Giorda C, Mannucci E, Medea G, Comaschi M, et al. The under-use of statin in type 2 diabetic patients attending diabetic clinics in Italy. Nutr Metab Cardiovasc Dis. 2007;17:32–40
  25. Targher G, Bertolini L, Padovani R, Rodella S, Tessari R, Zenari L, et al. Prevalence of non-alcoholic fatty liver disease and its association with cardiovascular disease among type 2 diabetic patients. Diabetes Care. 2007;30:1212–1218
  26. National Kidney Foundation . K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification and stratification. Am J Kidney Dis. 2002;39(Suppl. 1):S1–S266
  27. American Diabetes Association . Standards of medical care in diabetes-2009. Diabetes Care. 2009;31(Suppl. 1):S13–S61
  28. World Health Organization . International classification of diseases, ninth revision, clinical modification (ICD-9-CM). Washington, DC: Health Care Financing Administration, Public Health Service, US Department of Health and Human Services; 1991;
  29. Hsu CY, Go AS, McCulloch CE, Darbinian J, Iribarren C. Exploring secular trends in the likelihood of receiving treatment for end-stage renal disease. Clin J Am Soc Nephrol. 2007;2:81–88
  30. Coresh J, Selvin E, Stevens LA, Manzi J, Kusek JW, Eggers P, et al. Prevalence of chronic kidney disease in the United States. JAMA. 2007;298:2038–2047
  31. Irie F, Iso H, Sairenchi T, Fukasawa N, Yamagishi K, Ikehara S, et al. The relationships of proteinuria, serum creatinine, glomerular filtration rate with cardiovascular disease mortality in Japanese general population. Kidney Int. 2006;69:1264–1271
  32. Astor BC, Hallan SI, Miller ER, Yeung E, Coresh J. Glomerular filtration rate, albuminuria, and risk of cardiovascular and all-cause mortality in the US population. Am J Epidemiol. 2008;167:1226–1234
  33. Schiffrin EL, Lipman ML, Mann JFE. Chronic kidney disease: effects on the cardiovascular system. Circulation. 2007;116:85–97
  34. Stevens LA, Coresh J, Greene T, Levey AS. Assessing kidney function-measured and estimated glomerular filtration rate. N Engl J Med. 2006;354:2473–2483
  35. Sarnak MJ, Levey AS, Schoolwerth AC, Coresh J, Culleton B, Hamm LL, et al. American heart association councils on kidney in cardiovascular disease, high blood pressure research, clinical cardiology, and epidemiology and prevention. Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American heart association councils on kidney in cardiovascular disease, high blood pressure research, clinical cardiology, and epidemiology and prevention. Circulation. 2003;108:2154–2169

PII: S0939-4753(09)00236-1

doi: 10.1016/j.numecd.2009.10.002

Nutrition, Metabolism & Cardiovascular Diseases
Volume 21, Issue 4 , Pages 294-301 , April 2011

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