Plasma adiponectin concentration is strongly associated with VLDL-TG catabolism in postmenopausal women

Lapointe, A.; Tchernof, A.; Lamarche, B.; Piché, M.E.; Weisnagel, J.; Bergeron, J.; Lemieux, S.

doi:10.1016/j.numecd.2009.10.007

« Previous Next »Nutrition, Metabolism & Cardiovascular Diseases
Volume 21, Issue 4 , Pages 254-260, April 2011

Plasma adiponectin concentration is strongly associated with VLDL-TG catabolism in postmenopausal women

A. Lapointe
- Institute of Nutraceuticals and Functional Foods, Laval University, 2440 Hochelaga Blvd, Québec G1V 0A6, Canada
A. Tchernof
- Molecular Endocrinology and Oncology Research Center, CHUQ, Laval University, Québec, Canada
B. Lamarche
- Institute of Nutraceuticals and Functional Foods, Laval University, 2440 Hochelaga Blvd, Québec G1V 0A6, Canada
M.E. Piché
- Institute of Nutraceuticals and Functional Foods, Laval University, 2440 Hochelaga Blvd, Québec G1V 0A6, Canada
J. Weisnagel
- Diabetes Research Unit, CHUQ, Laval University, Québec, Canada
- Lipid Research Center, CHUQ, Laval University, Québec, Canada
J. Bergeron
- Lipid Research Center, CHUQ, Laval University, Québec, Canada
S. Lemieux
- Institute of Nutraceuticals and Functional Foods, Laval University, 2440 Hochelaga Blvd, Québec G1V 0A6, Canada
- Lipid Research Center, CHUQ, Laval University, Québec, Canada
- Corresponding author. Institute of Nutraceuticals and Functional Foods, Laval University, 2440 Hochelaga Blvd, Québec G1V 0A6, Canada. Tel.: +1 418 656 2131x3637; fax: +1 418 656 5877.

Received 12 June 2009; received in revised form 16 October 2009; accepted 20 October 2009. published online 15 February 2010.

Abstract

Background and aims

To investigate associations between plasma adiponectin concentration and very-low density lipoprotein–triglyceride (VLDL-TG) secretion and catabolism in postmenopausal women.

Methods and results

This cross-sectional study included 30 postmenopausal women. Plasma adiponectin concentration was measured by ELISA. Insulin sensitivity was assessed by a 2-h euglycemic-hyperinsulinemic clamp. Fasting plasma glucose (FPG) and 2-hour plasma glucose (2hPG) were measured during an oral glucose tolerance test. The calculation of VLDL-TG fractional catabolic rate (FCR) and VLDL-TG total secretion rate (TSR) were based on the monoexponential decrease of TG-[²H₅] glycerol values obtained following the administration of a ²H₅-glycerol bolus. Plasma adiponectin concentration was negatively associated with VLDL-TG TSR (r=−0.50; p=0.005) and positively associated with VLDL-TG FCR (r=0.54; p<0.002). This latter association remained significant after further adjustments for insulin sensitivity, visceral adipose tissue, HDL-C, FPG and 2hPG concentrations. In a multivariate model including adiponectin, insulin sensitivity and 2hPG, plasma adiponectin level was the strongest correlate of VLDL-TG FCR.