Nutrition, Metabolism & Cardiovascular Diseases
Volume 21, Issue 8 , Pages 576-583 , August 2011

The effect of vitamin–mineral supplementation on CRP and IL-6: A systemic review and meta-analysis of randomised controlled trials

  • C.-H. Sun

      Affiliations

    • Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin 150086, Heilongjiang Province, China
    • Corresponding Author InformationCorresponding author. Tel.: +86 451 8750 2801; fax: +86 451 8750 2885.
    • Chang-Hao Sun and Ying Li contributed equally to this work.
    • ,
  • Y. Li

      Affiliations

    • Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin 150086, Heilongjiang Province, China
    • Chang-Hao Sun and Ying Li contributed equally to this work.
    • ,
  • Y.-B. Zhang

      Affiliations

    • Department of Environmental Hygiene, Public Health College, Harbin Medical University, Harbin 150086, Heilongjiang Province, China
    • ,
  • F. Wang

      Affiliations

    • Department of Epidemiology, Public Health College, Harbin Medical University, Harbin 150086, Heilongjiang Province, China
    • ,
  • X.-L. Zhou

      Affiliations

    • Second Clinical College, Harbin Medical University, Harbin 150086, Heilongjiang Province, China
    • ,
  • F. Wang

      Affiliations

    • Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin 150086, Heilongjiang Province, China

Received 4 September 2009 ,Revised 7 December 2009 ,Accepted 29 December 2009.

References 

  1. Libby P. Inflammation in atherosclerosis. Nature. 2002;420(6917):868–874
  2. Ross R. Atherosclerosis – an inflammatory disease. N Engl J Med. 1999;340(2):115–126
  3. Holvoet P. Relations between metabolic syndrome, oxidative stress and inflammation and cardiovascular disease. Verh K Acad Geneeskd Belg. 2008;70(3):193–219
  4. Singh U, Devaraj S, Vitamin E. inflammation and atherosclerosis. Vitam Horm. 2007;76:519–549
  5. Singh U, Devaraj S, Jialal I, Vitamin E. oxidative stress, and inflammation. Annu Rev Nutr. 2005;25:151–174
  6. Mangoni AA, Arya R, Ford E, Asonganyi B, Sherwood RA, Ouldred E, et al. Effects of folic acid supplementation on inflammatory and thrombogenic markers in chronic smokers. A randomised controlled trial. Thromb Res. 2003;110(1):13–17
  7. Tousoulis D, Antoniades C, Tentolouris C, Tsioufis C, Toutouza M, Toutouzas P, et al. Effects of combined administration of vitamins C and E on reactive hyperemia and inflammatory process in chronic smokers. Atherosclerosis. 2003;170(2):261–267
  8. Vincent HK, Bourguignon CM, Vincent KR, Weltman AL, Bryant M, Taylor AG. Antioxidant supplementation lowers exercise-induced oxidative stress in young overweight adults. Obes (Silver Spring). 2006;14(12):2224–2235
  9. Mangoni AA. Folic acid, inflammation, and atherosclerosis: false hopes or the need for better trials?. Clin Chim Acta. 2006;367(1–2):11–19
  10. Ziegler S, Mittermayer F, Plank C, Minar E, Wolzt M, Schernthaner GH. Homocyst(e)ine-lowering therapy does not affect plasma asymmetrical dimethylarginine concentrations in patients with peripheral artery disease. J Clin Endocrinol Metab. 2005;90(4):2175–2178
  11. Prabhu Anand S, Selvaraj P, Narayanan PR. Effect of 1,25 dihydroxyvitamin D3 on intracellular IFN-gamma and TNF-alpha positive T cell subsets in pulmonary tuberculosis. Cytokine. 2009;45(2):105–110
  12. Block G, Jensen C, Dietrich M, Norkus EP, Hudes M, Packer L. Plasma C-reactive protein concentrations in active and passive smokers: influence of antioxidant supplementation. J Am Coll Nutr. 2004;23(2):141–147
  13. Attallah N, Osman-Malik Y, Frinak S, Besarab A. Effect of intravenous ascorbic acid in hemodialysis patients with EPO-hyporesponsive anemia and hyperferritinemia. Am J Kidney Dis. 2006;47(4):644–654
  14. Wang C, Li Y, Zhu K, Dong YM, Sun CH. Effects of supplementation with multivitamin and mineral on blood pressure and C-reactive protein in obese Chinese women with increased cardiovascular disease risk. Asia Pac J Clin Nutr. 2009;18(1):121–130
  15. Ahmad SM, Haskell MJ, Raqib R, Stephensen CB. Markers of innate immune function are associated with vitamin A stores in men. J Nutr. 2009;139(2):377–385
  16. Shea MK, Dallal GE, Dawson-Hughes B, Ordovas JM, O'Donnell CJ, Gundberg CM, et al. Circulating cytokines, and bone mineral density in older men and women. Am J Clin Nutr. 2008;88(2):356–363
  17. Grey A, Gamble G, Ames R, Horne A, Mason B, Reid IR. Calcium supplementation does not affect CRP levels in postmenopausal women–a randomized controlled trial. Osteoporos Int. 2006;17(8):1141–1145
  18. Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary?. Control Clin Trials. 1996;17(1):1–12
  19. Rosner B. Fundamentals of biostatistics. 6th ed.. Belmont, CA: Thomson-Brooks/Cole; 2006;pp. 141–145
  20. Ioannidou E, Malekzadeh T, Dongari-Bagtzoglou A. Effect of periodontal treatment on serum C-reactive protein levels: a systematic review and meta-analysis. J Periodontol. 2006;77(10):1635–1642
  21. Singh I, Turner AH, Sinclair AJ, Li D, Hawley JA. Effects of gamma-tocopherol supplementation on thrombotic risk factors. Asia Pac J Clin Nutr. 2007;16(3):422–428
  22. Tahir M, Foley B, Pate G, Crean P, Moore D, McCarroll N, et al. Impact of vitamin E and C supplementation on serum adhesion molecules in chronic degenerative aortic stenosis: a randomized controlled trial. Am Heart J. 2005;150(2):302–306
  23. Devaraj S, Leonard S, Traber MG, Jialal I. Gamma-tocopherol supplementation alone and in combination with alpha-tocopherol alters biomarkers of oxidative stress and inflammation in subjects with metabolic syndrome. Free Radic Biol Med. 2008;44(6):1203–1208
  24. Pittas AG, Harris SS, Stark PC, Dawson-Hughes B. The effects of calcium and vitamin D supplementation on blood glucose and markers of inflammation in nondiabetic adults. Diab Care. 2007;30(4):980–986
  25. Ravn-Haren G, Bugel S, Krath BN, Hoac T, Stagsted J, Jorgensen K, et al. A short-term intervention trial with selenate, selenium-enriched yeast and selenium-enriched milk: effects on oxidative defence regulation. T Br J Nutr. 2008;99(4):883–892
  26. Peairs AT, Rankin JW. Inflammatory response to a high-fat, low-carbohydrate weight loss diet: effect of antioxidants. Obes (Silver Spring). 2008;16(7):1573–1578
  27. Lu Q, Bjorkhem I, Wretlind B, Diczfalusy U, Henriksson P, Freyschuss A. Effect of ascorbic acid on microcirculation in patients with type II diabetes: a randomized placebo-controlled cross-over study. Clin Sci (Lond). 2005;108(6):507–513
  28. Fumeron C, Nguyen-Khoa T, Saltiel C, Kebede M, Buisson C, Drueke TB, et al. Effects of oral vitamin C supplementation on oxidative stress and inflammation status in haemodialysis patients. Nephrol Dial Transplant. 2005;20(9):1874–1879
  29. Serwin AB, Wasowicz W, Chodynicka B. Selenium supplementation, soluble tumor necrosis factor-alpha receptor type 1, and C-reactive protein during psoriasis therapy with narrowband ultraviolet B. Nutrition. 2006;22(9):860–864
  30. Korantzopoulos P, Kolettis TM, Kountouris E, Dimitroula V, Karanikis P, Pappa E, et al. Oral vitamin C administration reduces early recurrence rates after electrical cardioversion of persistent atrial fibrillation and attenuates associated inflammation. Int J Cardiol. 2005;102(2):321–326
  31. Solini A, Santini E, Ferrannini E. Effect of short-term folic acid supplementation on insulin sensitivity and inflammatory markers in overweight subjects. Int J Obes (Lond). 2006;30(8):1197–1202
  32. Kaidar-Person O, Person B, Szomstein S, Rosenthal RJ. Nutritional deficiencies in morbidly obese patients: a new form of malnutrition?: part A: vitamins. Obes Surg. 2008;
  33. Kaidar-Person O, Person B, Szomstein S, Rosenthal RJ. Nutritional deficiencies in morbidly obese patients: a new form of malnutrition? part B: minerals. Obes Surg. 2008;18(8):1028–1034
  34. Calabro P, Chang DW, Willerson JT, Yeh ET. Release of C-reactive protein in response to inflammatory cytokines by human adipocytes: linking obesity to vascular inflammation. J Am Coll Cardiol. 2005;46(6):1112–1113
  35. Flechtner-Mors M, Ditschuneit HH, Johnson TD, Suchard MA, Adler G. Metabolic and weight loss effects of long-term dietary intervention in obese patients: four-year results. Obes Res. 2000;8(5):399–402
  36. Church TS, Earnest CP, Wood KA, Kampert JB. Reduction of C-reactive protein levels through use of a multivitamin. Am J Med. 2003;115(9):702–707
  37. Sandstrom B. Micronutrient interactions: effects on absorption and bioavailability. Br J Nutr. 2001;85(Suppl. 2):S181–S185

☆ Source of Funding: This work was supported by Natural Science Foundation of China (No. 30471445), China's 11th Five-Year Scientific and Technical Plan (No. 2006BAD27B05).

PII: S0939-4753(10)00007-4

doi: 10.1016/j.numecd.2009.12.014

Nutrition, Metabolism & Cardiovascular Diseases
Volume 21, Issue 8 , Pages 576-583 , August 2011

Article Tools

* Image Usage & Resolution