Nutrition, Metabolism & Cardiovascular Diseases
Volume 21, Issue 9 , Pages 651-657 , September 2011

Association of plasma markers of cholesterol homeostasis with metabolic syndrome components. A cross-sectional study

  • M. Cofán

      Affiliations

    • Lipid Clinic, Endocrinology and Nutrition Service, Biomedical Research Institute August Pi i Sunyer, Hospital Clínic, Barcelona, Spain
    • CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III (ISCIII), Spain
    • Corresponding Author InformationCorresponding author. Lipid Clinic, Endocrinology and Nutrition Service, Hospital Clínic, Villarroel 170, 08036 Barcelona, Spain. Tel.: +34 636 295 015; fax: +34 93 227 56 97.
    • These authors equally contributed to this work.
    • ,
  • V. Escurriol

      Affiliations

    • Lipid Clinic, Endocrinology and Nutrition Service, Biomedical Research Institute August Pi i Sunyer, Hospital Clínic, Barcelona, Spain
    • CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III (ISCIII), Spain
    • These authors equally contributed to this work.
    • ,
  • A.L. García-Otín

      Affiliations

    • Lipid Unit and Molecular Biology Laboratory, Hospital Universitario Miguel Servet, Instituto Aragonés de Ciencias de la Salud, Zaragoza, Spain
    • ,
  • C. Moreno-Iribas

      Affiliations

    • Public Health Institute of Navarra, Pamplona, Spain
    • CIBER Epidemiología y Salud Pública (CIBEResp), ISCIII, Spain
    • Department of Pediatrics, Obstetrics, Gynecology and Preventive Medicine, Autonoma University of Barcelona, Barcelona, Spain
    • ,
  • N. Larrañaga

      Affiliations

    • CIBER Epidemiología y Salud Pública (CIBEResp), ISCIII, Spain
    • Public Health Department of Gipuzkoa, Gipuzkoa, Spain
    • ,
  • M.J. Sánchez

      Affiliations

    • CIBER Epidemiología y Salud Pública (CIBEResp), ISCIII, Spain
    • Andalusian School of Public Health, Granada, Spain
    • ,
  • M.J. Tormo

      Affiliations

    • CIBER Epidemiología y Salud Pública (CIBEResp), ISCIII, Spain
    • Department of Epidemiology, Regional Health Council, Murcia, Spain
    • ,
  • M.L. Redondo

      Affiliations

    • Public Health Directorate, Health and Health Care Services Council, Asturias, Spain
    • ,
  • C.A. González

      Affiliations

    • Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology, Barcelona, Spain
    • RTIC RD06/0020, ISCIII, Spain
    • ,
  • D. Corella

      Affiliations

    • CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III (ISCIII), Spain
    • Department of Preventive Medicine and Public Health, School of Medicine, University of Valencia, Valencia, Spain
    • ,
  • M. Pocoví

      Affiliations

    • Departament of Biochemistry and Molecular and Cellular Biology, University of Zaragoza, Zaragoza, Spain
    • CIBER de Enfermedades Raras (CIBERer), ISCIII, Spain
    • ,
  • F. Civeira

      Affiliations

    • Lipid Unit and Molecular Biology Laboratory, Hospital Universitario Miguel Servet, Instituto Aragonés de Ciencias de la Salud, Zaragoza, Spain
    • RTIC C06/01(RECAVA), ISCIII, Spain
    • ,
  • E. Ros

      Affiliations

    • Lipid Clinic, Endocrinology and Nutrition Service, Biomedical Research Institute August Pi i Sunyer, Hospital Clínic, Barcelona, Spain
    • CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III (ISCIII), Spain

Received 29 July 2009 ,Revised 30 December 2009 ,Accepted 5 January 2010.

References 

  1. Moreau RA, Whitaker BD, Hicks KB. Phytosterols, phytostanols, and their conjugates in foods: structural diversity, quantitative analysis, and health-promoting uses. Progr Lipid Res. 2002;41:457–500
  2. von Bergmann K, Sudhop T, Lütjohann D. Cholesterol and plant sterol absorption: recent insights. Am J Cardiol. 2005;96(Suppl.):10D–14D
  3. Berge KE, Tian H, Graf GA, Yu L, Grishin NV, Schultz J, et al. Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters. Science. 2000;290:1771–1775
  4. Chan YM, Varady KA, Lin Y, Trautwein E, Mensink RP, Plat J, et al. Plasma concentrations of plant sterols: physiology and relationship with coronary heart disease. Nutr Rev. 2006;64:385–402
  5. Katan MB, Grundy SM, Jones P, Law M, Miettinen T, Paoletti R. Efficacy and safety of plant stanols and sterols in the management of blood cholesterol levels. Mayo Clin Proc. 2003;78:965–978
  6. Miettinen TA, Tilvis RS, Kesäniemi YA. Serum plant sterols and cholesterol precursors reflect cholesterol absorption and synthesis in volunteers of a randomly selected male population. Am J Epidemiol. 1990;131:20–31
  7. Santosa S, Varady KA, AbuMweis S, Jones PJ. Physiological and therapeutic factors affecting cholesterol metabolism: does a reciprocal relationship between cholesterol absorption and synthesis really exist?. Life Sci. 2007;80:505–514
  8. Miettinen TA. Cholesterol production in obesity. Circulation. 1971;44:842–847
  9. Miettinen TA, Gylling H. Cholesterol absorption efficiency and sterol metabolism in obesity. Atherosclerosis. 2000;153:241–248
  10. Simonen P, Gylling H, Howard AN, Miettinen TA. Introducing a new component of the metabolic syndrome: low cholesterol absorption. Am J Clin Nutr. 2000;72:82–88
  11. Simonen PP, Gylling HK, Miettinen TA. Diabetes contributes to cholesterol metabolism regardless of obesity. Diabetes Care. 2002;25:1511–1515
  12. Pihlajamäki J, Gylling H, Miettinen TA, Laakso M. Insulin resistance is associated with increased cholesterol synthesis and decreased cholesterol absorption in normoglycemic men. J Lipid Res. 2004;45:507–512
  13. Chan DC, Watts GF, Barrett PH, O'Neill FH, Redgrave TG, Thompson GR. Relationships between cholesterol homoeostasis and triacylglycerol-rich lipoprotein remnant metabolism in the metabolic syndrome. Clin Sci (Lond). 2003;104:383–388
  14. Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, et al. American Heart Association; National Heart, Lung, and Blood Institute: Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation. 2005;112:2735–2752[erratum in Circulation 2005;112:e297–98]
  15. Bingham S, Riboli E. Diet and cancer. The European Prospective Investigation into Cancer and Nutrition. Nat Rev Cancer. 2004;4:206–215
  16. Durrington P. Dyslipidaemia. Lancet. 2003;362:717–731
  17. González CA. EPIC Group of Spain. Relative validity and reproducibility of a diet history questionnaire in Spain. I. Foods. Int J Epidemiol. 1997;26(Suppl. 1):S91–S99
  18. Jiménez-Escrig A, Santos-Hidalgo AB, Saura-Calixto F. Common sources and estimated intake of plant sterols in the Spanish diet. J Agric Food Chem. 2006;54:3462–3471
  19. Heinemann T, Axtmann G, von Bergmann K. Comparison of intestinal absorption of cholesterol with different plant sterols in man. Eur J Clin Invest. 1993;23:827–831
  20. Hixson JE, Vernier DT. Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. J Lipid Res. 1990;31:345–348
  21. Alberti KG, Zimmet P, Shaw J. The metabolic syndrome – a new worldwide definition. Lancet. 2005;366:1059–1062
  22. Miettinen TA, Gylling H. Cholesterol synthesis and absorption in coronary patients with lipid triad and isolated high LDL cholesterol in a 4S subgroup. Atherosclerosis. 2003;168:343–349
  23. Gylling H, Hallikainen M, Pihlajamäki J, Agren J, Laakso M, Rajaratnam RA, et al. Polymorphisms in the ABCG5 and ABCG8 genes associate with cholesterol absorption and insulin sensitivity. J Lipid Res. 2004;45:1660–1665
  24. Pinedo S, Vissers MN, von Bergmann K, Elharchaoui K, Lütjohann D, Luben R, et al. Plasma levels of plant sterols and the risk of coronary artery disease: the prospective EPIC-Norfolk Population Study. J Lipid Res. 2007;48:139–144
  25. Assmann G, Cullen P, Kannenberg F, Schulte H. Relationship between phytosterol levels and components of the metabolic syndrome in the PROCAM study. Eur J Cardiovasc Prev Rehabil. 2007;14:208–214
  26. Ory DS. Nuclear receptor signaling in the control of cholesterol homeostasis: have the orphans found a home?. Circ Res. 2004;95:660–670
  27. Yu L, York J, von Bergmann K, Lutjohann D, Cohen JC, Hobbs HH. Stimulation of cholesterol excretion by the liver X receptor agonist requires ATP-binding cassette transporters G5 and G8. J Biol Chem. 2003;278:15565–15570
  28. Field FJ, Watt K, Mathur SN. Origins of intestinal ABCA1-mediated HDL-cholesterol. J Lipid Res. 2008;49:2605–2619

☆ Disclosure statement: the authors have no disclosures.

PII: S0939-4753(10)00013-X

doi: 10.1016/j.numecd.2010.01.005

Nutrition, Metabolism & Cardiovascular Diseases
Volume 21, Issue 9 , Pages 651-657 , September 2011

Article Tools

* Image Usage & Resolution