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Nutrition, Metabolism & Cardiovascular Diseases
Volume 22, Issue 1
, Pages
58-65
, January 2012
Effects of chronic elevation of atrial natriuretic peptide and free fatty acid levels in the induction of type 2 diabetes mellitus and insulin resistance in patients with mitral valve disease
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In the left part are reported blood glucose (upper), serum insulin (middle) and plasma FFA (lower) profiles during the glucose load (0–120 min) in 50 MVD (black triangle) and in 55 CHD (white triangle
In the left part are reported blood glucose (upper), serum insulin (middle) and plasma FFA (lower) profiles during the glucose load (0–120 min) in 50 MVD (black triangle) and in 55 CHD (white triangle) before and after valve replacement/repair or CABG and in 166 normal controls (NC; white circle). § p < 0.01 MVD vs NC; *p < 0.01 CHD vs NC; + p < 0.01 MVD vs CHD. In the right part of the slide are reported SI index (upper), ΔAUC Insulin (middle) and AUC FFA (lower) in 50 MVD before (
) and after valve replacement/repair (
), in 55 CHD before (
) and after CABG (
) and in 166 normal controls (NC; 
). Data are presented as Mean ± SD. -
In the upper part, LA Volume (left part) and ANP levels (right part) in 50 MVD before () and after valve replacement/repair (), in 55 CHD before () and after CABG () and in 166 normal controls (NC; ).In the upper part, LA Volume (left part) and ANP levels (right part) in 50 MVD before (
) and after valve replacement/repair (), in 55 CHD before () and after CABG () and in 166 normal controls (NC; ). Data are presented as Mean ± SD. In the lower part, in patients with MVD, ANP levels were positively correlated with LA Volume (left part) and the Δ decrement of ANP was positively correlated with Δ decrement of LA Volume (right part). -
AUC FFA significantly and positively correlated with LA (upper part) and ANP levels (middle part) in MVD while AUC FFA significantly and positively correlated with IL-6 in CHD (lower part).AUC FFA significantly and positively correlated with LA (upper part) and ANP levels (middle part) in MVD while AUC FFA significantly and positively correlated with IL-6 in CHD (lower part).
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Reciprocal relationship between estimates of insulin sensitivity and insulin secretion, both obtained from the oral glucose load. The x-axis reports insulin sensitivity (IS index; mmol kg−1 min−1 pmolReciprocal relationship between estimates of insulin sensitivity and insulin secretion, both obtained from the oral glucose load. The x-axis reports insulin sensitivity (IS index; mmol kg−1 min−1 pmol/l) levels, whereas the Y axis reports ΔAUC insulin areas (μU/ml; 0–120 min), indicative of insulin secretion. Small black dots are individual values of the 2 variables found in normal controls while the large white square represents their mean value (±SD for both variables). The solid line is the hyperbolic function fitting the relationship between insulin sensitivity and insulin secretion in normal controls. Mean values (±SD) found in MVD patients before and after surgery and in CAD before and after CABG are reported.
) and after valve replacement/repair (
), in 55 CHD before (
) and after CABG (
) and in 166 normal controls (NC; 
). Data are presented as Mean ± SD.PII: S0939-4753(10)00103-1
doi: 10.1016/j.numecd.2010.04.005
© 2010 Elsevier B.V. All rights reserved.
« Previous
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Nutrition, Metabolism & Cardiovascular Diseases
Volume 22, Issue 1
, Pages
58-65
, January 2012
