Nutrition, Metabolism & Cardiovascular Diseases
Volume 20, Issue 9 , Pages e17-e18 , November 2010

Poor vitamin B6 status: A novel potential thrombotic factor in chronic obstructive pulmonary disease

  • Filippo Luca Fimognari

      Affiliations

    • Corresponding Author InformationCorresponding author at: Unità Operativa Complessa di Geriatria, Azienda Ospedaliera di Cosenza, Via Felice Migliori, 87100 Cosenza, Italy. Tel.: +39 0984681346; fax: +39 0984681521.

Received 22 February 2010 ,Revised 31 May 2010 ,Accepted 10 June 2010.

References 

  1. Vanuzzo D, Pilotto L, Lombardi R, Lazzerini G, Carluccio M, Diviacco S, et al. Both vitamin B6 and total homocysteine plasma levels predict long-term atherothrombotic events in healthy subjects. Eur Heart J. 2007;28:484–491
  2. Morris MS, Sakakeeny L, Jacques PF, Picciano MF, Selhub J. Vitamin B6 intake is inversely related to, and the requirement is affected by, inflammatory status. J Nutr. 2010;140:103–110
  3. Johnston AK, Mannino DM, Hagan GW, Davis KJ, Kiri VA. Relationship between lung function impairment and incidence or recurrence of cardiovascular events in a middle-aged cohort. Thorax. 2008;63:599–605
  4. Fimognari FL, Loffredo L, Di Simone S, Sampietro F, Pastorelli R, Monaldo M, et al. Hyperhomocysteinaemia and poor vitamin B status in chronic obstructive pulmonary disease. Nutr Metab Cardiovasc Dis. 2009;19:654–659
  5. Camp VM, Chipponi J, Faraj BA. Radioenzymatic assay for direct measurement of plasma pyridoxal-5’-phosphate. Clin Chem. 1983;29:642–644
  6. Turato G, Zuin R, Miniati M, Baraldo S, Rea F, Beghè B, et al. Airway inflammation in severe chronic obstructive pulmonary disease. Relationship with lung function and radiologic emphysema. Am J Respir Crit Care Med. 2002;166:105–122
  7. Chiang EP, Smith DE, Selhub J, Dallal G, Wang YC, Roubenoff R. Inflammation causes tissue-specific depletion of vitamin B6. Arthritis Res Ther. 2005;7:R1254–R1262
  8. Seemungal TA, Cho Fook Lun J, Davis G, Neblett C, Chinyepi N, Dookhan C, et al. Plasma homocysteine is elevated in COPD patients and is related to COPD severity. Int J Chron Obstruct Pulmon Dis. 2007;2:313–321

PII: S0939-4753(10)00141-9

doi: 10.1016/j.numecd.2010.06.008

Nutrition, Metabolism & Cardiovascular Diseases
Volume 20, Issue 9 , Pages e17-e18 , November 2010

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