Advertisement

Effects of moderate beer consumption on blood lipid profile in healthy Spanish adults

  • Javier Romeo
    Correspondence
    Corresponding author. Tel.: +34 91 544 5607; fax: +34 91 549 3627.
    Affiliations
    Grupo Inmunonutrición, Departamento de Metabolismo y Nutrición, Instituto del Frío, Consejo Superior de Investigaciones Científicas, C/José Antonio Novais, 10, 28040 Madrid, Spain
    Search for articles by this author
  • Marcela González-Gross
    Affiliations
    Grupo Inmunonutrición, Departamento de Metabolismo y Nutrición, Instituto del Frío, Consejo Superior de Investigaciones Científicas, C/José Antonio Novais, 10, 28040 Madrid, Spain
    Search for articles by this author
  • Julia Wärnberg
    Affiliations
    Grupo Inmunonutrición, Departamento de Metabolismo y Nutrición, Instituto del Frío, Consejo Superior de Investigaciones Científicas, C/José Antonio Novais, 10, 28040 Madrid, Spain
    Search for articles by this author
  • Ligia E. Díaz
    Affiliations
    Grupo Inmunonutrición, Departamento de Metabolismo y Nutrición, Instituto del Frío, Consejo Superior de Investigaciones Científicas, C/José Antonio Novais, 10, 28040 Madrid, Spain
    Search for articles by this author
  • Ascensión Marcos
    Affiliations
    Grupo Inmunonutrición, Departamento de Metabolismo y Nutrición, Instituto del Frío, Consejo Superior de Investigaciones Científicas, C/José Antonio Novais, 10, 28040 Madrid, Spain
    Search for articles by this author
Published:November 02, 2007DOI:https://doi.org/10.1016/j.numecd.2007.03.007

      Abstract

      Background and aims

      To analyse the association of moderate beer consumption on the blood lipid profile in healthy Spanish adults.

      Methods and results

      The study had an intervention longitudinal design in which each subject established their own control with a previous wash-out phase. After a 30-day alcohol abstinence period, 57 healthy volunteers were submitted to a daily moderate intake of beer for 30 days. Serum total cholesterol, HDL-cholesterol, triacylglycerols, GOT, GPT, GGT and glucose values, as well as blood erythrocytes, haemoglobin, haematocrit and MCV levels, together with anthropometric parameters were determined at the beginning of the study (baseline levels) (a), after 1 month of alcoholic abstinence (b) and after 1 month of moderate beer consumption (c). Dietary intake was assessed twice by a 7-day dietary record.
      HDL-cholesterol, erythrocytes, haematocrit and MCV levels increased significantly (p < 0.05) after moderate beer consumption in women. In men, a decrease in HDL-cholesterol levels was observed after alcohol abstention. Haematocrit and MCV counts also increased significantly (p < 0.05) in men after moderate beer consumption. There were no dietary changes during the study.

      Conclusion

      In healthy Spanish adults, the effects of moderate beer consumption during 1 month were associated with favourable changes on the blood lipid profile.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Nutrition, Metabolism and Cardiovascular Diseases
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Keys A.
        The Seven Countries. A multivariate analysis of death and coronary heart disease.
        Harvard University Press, London1980
        • Cleophas T.J.
        Wine, beer and spirits and the risk of myocardial infarction: a systematic review.
        Biomed Pharmacother. 1999; 53: 417-423
        • Gaziano J.M.
        • Gaziano T.A.
        • Glynn R.J.
        • Sesso H.D.
        • Ajani U.A.
        • Stampfer M.J.
        • et al.
        Light-to-moderate alcohol consumption and mortality in the Physicians’ Health Study enrollment cohort.
        J Am Coll Cardiol. 2000; 35: 96-105
        • Gronbaek M.
        • Becker U.
        • Johansen D.
        • Gottschau A.
        • Schnohr P.
        • Hein H.O.
        • et al.
        Type of alcohol consumed and mortality from all causes, coronary heart disease, and cancer.
        Ann Intern Med. 2000; 133: 411-419
        • Darioli R.
        Alcohol and risk of coronary heart disease.
        Ther Umsch. 2005; 62: 638-640
        • Mukamal K.J.
        • Ascherio A.
        • Mittleman M.A.
        • Conigrave K.M.
        • Camargo C.A.
        • Kawachi I.
        • et al.
        Alcohol and risk for ischemic stroke in men: the role of drinking patterns and usual beverage.
        Ann Intern Med. 2005; 142: 11-19
        • de Gaetano G.
        • Cerletti C.
        Wine and cardiovascular disease.
        Nutr Metab Cardiovasc Dis. 2001; 11: 47-50
        • van Velden D.P.
        • Mansvelt E.P.
        • Fourie E.
        • Rossouw M.
        • Marais A.D.
        The cardioprotective effect of wine on human blood chemistry.
        Ann N Y Acad Sci. 2002; 957: 337-340
        • Naissides M.
        • Mamo J.C.
        • James A.P.
        • Pal S.
        The effect of chronic consumption of red wine on cardiovascular disease risk factors in postmenopausal women.
        Atherosclerosis. 2006; 185: 438-445
        • Zuccala G.
        • Onder G.
        • Pedone C.
        • Cesari M.
        • Landi F.
        • Bernabei R.
        • et al.
        Dose-related impact of alcohol consumption on cognitive function in advanced age: results of a multicenter survey.
        Alcohol Clin Exp Res. 2001; 25: 1743-1748
        • Stampfer M.J.
        • Kang J.H.
        • Chen J.
        • Cherry R.
        • Grodstein F.
        Effects of moderate alcohol consumption on cognitive function in women.
        N Engl J Med. 2005; 352: 245-253
        • Standridge J.B.
        • Zylstra R.G.
        • Adams S.M.
        Alcohol consumption: an overview of benefits and risks.
        South Med J. 2004; 97: 664-672
        • La Vecchia C.
        • Negri E.
        • Franceschi S.
        • D'Avanzo B.
        Moderate beer consumption and the risk of colorectal cancer.
        Nutr Cancer. 1993; 19: 303-306
        • Cambou J.P.
        A practical approach to the evaluation of excessive alcohol drinking.
        Ann Cardiol Angeiol. 2002; 51: 321-326
        • Keil U.
        • Chambless L.E.
        • Doring A.
        • Filipiak B.
        • Stieber J.
        The relation of alcohol intake to coronary heart disease and all-cause mortality in a beer-drinking population.
        Epidemiology. 1997; 8: 150-156
        • Thun M.J.
        • Peto R.
        • Lopez A.D.
        • Monaco J.H.
        • Henley S.J.
        • Heath C.W.
        • et al.
        Alcohol consumption and mortality among middle-aged and elderly U.S. adults.
        N Engl J Med. 1997; 337: 1705-1714
        • Rimm E.
        Alcohol and cardiovascular disease.
        Curr Atheroscler Rep. 2000; 2: 529-535
        • González-Gross M.
        • Lebron M.
        • Marcos A.
        Revisión bibliográfica sobre los efectos del consumo moderado de cerveza sobre la salud.
        Centro de Información Cerveza y Salud, Madrid2000
        • Diaz L.E.
        • Montero A.
        • González-Gross M.
        • Vallejo A.I.
        • Romeo J.
        • Marcos A.
        Influence of alcohol consumption on immunological status: a review.
        Eur J Clin Nutr. 2002; 56: 50-53
        • Lieber C.S.
        Ethnic and gender differences in ethanol metabolism.
        Alcohol Clin Exp Res. 2000; 24: 417-418
        • Baraona E.
        • Abittan C.S.
        • Dohmen K.
        • Moretti M.
        • Pozzato G.
        • Chayes Z.
        • et al.
        Gender differences in pharmacokinetics of alcohol.
        Alcohol Clin Exp Res. 2001; 25: 502-507
        • Hommer D.
        • Momenan R.
        • Kaiser E.
        • Rawlings R.
        Evidence for a gender-related effect of alcoholism on brain volumes.
        Am J Psychiatry. 2001; 158: 198-204
        • Holmila M.
        • Raitasalo K.
        Gender differences in drinking: why do they still exist?.
        Addiction. 2005; 100: 1763-1769
        • Burger M.
        • Bronstrup A.
        • Pietrzik K.
        Derivation of tolerable upper alcohol intake levels in Germany: a systematic review of risks and benefits of moderate alcohol consumption.
        Prev Med. 2004; 39: 111-127
        • Vinson J.A.
        • Mandarano M.
        • Hirst M.
        • Trevithick J.R.
        • Bose P.
        Phenol antioxidant quantity and quality in foods: beers and the effect of two types of beer on an animal model of atherosclerosis.
        J Agric Food Chem. 2003; 51: 5528-5533
        • Sripanyakorn S.
        • Jugdaohsingh R.
        • Elliott H.
        • Walker C.
        • Mehta P.
        • Shoukru S.
        • et al.
        The silicon content of beer and its bioavailability in healthy volunteers.
        Br J Nutr. 2004; 91: 403-409
        • Nardini M.
        • Natella F.
        • Scaccini C.
        • Ghiselli A.
        Phenolic acids from beer are absorbed and extensively metabolized in humans.
        J Nutr Biochem. 2006; 17: 14-22
        • KondoBeer K.
        health: preventive effects of beer components on lifestyle-related diseases.
        Biofactors. 2004; 22: 303-310
        • Hansen A.S.
        • Marckmann P.
        • Dragsted L.O.
        • Finne I.L.
        • Nielsen S.E.
        • Gronbaek M.
        Effect of red wine and red grape extract on blood lipids, haemostatic factors, and other risk factors for cardiovascular disease.
        Eur J Clin Nutr. 2005; 59: 449-455
        • Avellone G.
        • Di Garbo V.
        • Campisi D.
        • De Simone R.
        • Raneli G.
        • Scaglione R.
        • et al.
        Effects of moderate Sicilian red wine consumption on inflammatory biomarkers of atherosclerosis.
        Eur J Clin Nutr. 2006; 60: 41-47
        • Ruf J.C.
        Alcohol, wine and platelet function.
        Biol Res. 2004; 37: 209-215
      1. Wallach J. Interpretación Clínica de las pruebas de laboratorio. 4th ed. Madrid; 2003.

      2. Moreiras O, Carbajal A, Cabrera L y Cuadrado C. Tablas de composición de alimentos. Madrid: Ed. Pirámide; 2001.

        • Ruidavets J.B.
        • Ducimetiere P.
        • Arveiler D.
        • Amouyel P.
        • Bingham A.
        • Wagner A.
        • et al.
        Types of alcoholic beverages and blood lipids in a French population.
        J Epidemiol Community Health. 2002; 56: 24-28
        • Schroder H.
        • Ferrandez O.
        • Jimenez J.
        • Sanchez-Font A.
        • Marrugat J.
        Cardiovascular risk profile and type of alcohol beverage consumption: a population-based study.
        Ann Nutr Metab. 2005; 49: 100-106
        • Brenner H.
        • Rothenbacher D.
        • Bode G.
        • Marz W.
        • Hoffmeister A.
        • Koenig W.
        Coronary heart disease risk reduction in a predominantly beer-drinking population.
        Epidemiology. 2001; 12: 390-395
        • van der Gaag M.S.
        • van Tol A.
        • Vermunt S.H.
        • Scheek L.M.
        • Schaafsma G.
        • Hendriks H.F.
        Alcohol consumption stimulates early steps in reverse cholesterol transport.
        J Lipid Res. 2001; 42: 2077-2083
        • Sierksma A.
        • van der Gaag M.S.
        • Kluft C.
        • Hendriks H.F.
        Moderate alcohol consumption reduces plasma C-reactive protein and fibrinogen levels; a randomized, diet-controlled intervention study.
        Eur J Clin Nutr. 2002; 56: 1130-1136
        • Hartung G.H.
        • Foreyt J.P.
        • Mitchell R.E.
        • Mitchell J.G.
        • Reeves R.S.
        • Gotto Jr., A.M.
        Effect of alcohol intake on high-density lipoprotein cholesterol levels in runners and inactive men.
        JAMA. 1983; 249: 747-750
        • Masarei J.R.
        • Puddey I.B.
        • Rouse I.L.
        • Lynch W.J.
        • Vandongen R.
        • Beilin L.J.
        Effects of alcohol consumption on serum lipoprotein-lipid and apolipoprotein concentrations. Results from an intervention study in healthy subjects.
        Atherosclerosis. 1986; 60: 79-87
        • Hartung G.H.
        • Foreyt J.P.
        • Reeves R.S.
        • Krock L.P.
        • Patsch W.
        • Patsch J.R.
        • et al.
        Effect of alcohol dose on plasma lipoprotein subfractions and lipolytic enzyme activity in active and inactive men.
        Metabolism. 1990; 39: 81-86
        • Baer D.J.
        • Judd J.T.
        • Clevidence B.A.
        • Muesing R.A.
        • Campbell W.S.
        • Brown E.D.
        • et al.
        Moderate alcohol consumption lowers risk factors for cardiovascular disease in postmenopausal women fed a controlled diet.
        Am J Clin Nutr. 2002; 75: 593-599
        • Gaziano J.M.
        • Buring J.E.
        • Breslow J.L.
        • Goldhaber S.Z.
        • Rosner B.
        • VanDenburgh M.
        • et al.
        Moderate alcohol intake, increased levels of high-density lipoprotein and its subfractions, and decreased risk of myocardial infarction.
        N Engl J Med. 1993; 329: 1829-1934
        • Schlienger J.L.
        Alcohol and cardiovascular system: mechanisms of the protective effects.
        Pathol Biol. 2001; 49: 764-768
        • Djousse L.
        • Arnett D.K.
        • Eckfeldt J.H.
        • Province M.A.
        • Singer M.R.
        • Ellison R.C.
        Alcohol consumption and metabolic syndrome: does the type of beverage matter?.
        Obes Res. 2004; 12: 1375-1385
        • Parker D.R.
        • McPhillips J.B.
        • Derby C.A.
        • Gans K.M.
        • Lasater T.M.
        • Carleton R.A.
        High-density-lipoprotein cholesterol and types of alcoholic beverages consumed among men and women.
        Am J Public Health. 1996; 86: 1022-1027
        • Freiberg M.S.
        • Cabral H.J.
        • Heeren T.C.
        • Vasan R.S.
        • Curtis Ellison R.
        Alcohol consumption and the prevalence of the Metabolic Syndrome in the US: a cross-sectional analysis of data from the Third National Health and Nutrition Examination Survey.
        Diabetes Care. 2004; 27: 2954-2959
        • Helander A.
        Biological markers in alcoholism.
        J Neural Transm. 2003; 66: 15-32
        • Anttila P.
        • Jarvi K.
        • Latvala J.
        • Romppanen J.
        • Punnonen K.
        • Niemela O.
        Biomarkers of alcohol consumption in patients classified according to the degree of liver disease severity.
        Scand J Clin Lab Invest. 2005; 65: 141-151
        • Baral N.
        • Pokhrel S.
        • Lamsal M.
        • Yadav B.N.
        • Sah S.P.
        Utility of gamma-glutamyl transpeptidase and mean corpuscular volume in alcoholic liver disease.
        Southeast Asian J Trop Med Publ Health. 2005; 36: 1007-1010
        • Sillanaukee P.
        • van der Gaag M.S.
        • Sierksma A.
        • Hendriks H.F.
        • Strid N.
        • Ponnio M.
        • et al.
        Effect of type of alcoholic beverages on carbohydrate-deficient transferrin, sialic acid, and liver enzymes.
        Alcohol Clin Exp Res. 2003; 27: 57-60
        • Whitehead T.P.
        • Robinson D.
        • Allaway S.L.
        • Hale A.C.
        The effects of cigarette smoking and alcohol consumption on blood haemoglobin, erythrocytes and leucocytes: a dose related study on male subjects.
        Clin Lab Haematol. 1995; 17: 131-138
        • Ballard H.S.
        The hematological complications of alcoholism.
        Alcohol Health Res World. 1997; 21: 42-52
        • Latvala J.
        • Parkkila S.
        • Niemela O.
        Excess alcohol consumption is common in patients with cytopenia: studies in blood and bone marrow cells.
        Alcohol Clin Exp Res. 2004; 28: 619-624
        • Romeo J.
        • González-Gross M.
        • Wärnberg J.
        • Díaz L.E.
        • Marcos A.
        ¿Influye la cerveza en el aumento de peso? Efectos de un consumo moderado de cerveza sobre la composición corporal.
        Nutr Hosp. 2007; 22: 223-228
        • Bobak M.
        • Skodova Z.
        • MarmotBeer M.
        obesity: a cross-sectional study.
        Eur J Clin Nutr. 2003; 57: 1250-1253
        • Romeo J.
        • Díaz L.E.
        • González-Gross M.
        • Wärnberg J.
        • Marcos A.
        Contribución a la ingesta de macro y micro nutrientes que ejerce un consumo moderado de cerveza.
        Nutr Hosp. 2006; 2: 86-93