Abstract
Background and aims
To investigate the effect of moderate alcohol consumption on lipoprotein-associated
phospholipase A2 activity, markers of inflammation and oxidative stress and whether
these effects are modified by BMI.
Methods and results
Eleven lean (BMI: 18.5–25 kg/m2) and 9 overweight (BMI>27 kg/m2) men participated in a randomized controlled crossover trial. After consuming 3 cans
of beer (40 g ethanol) or alcohol-free beer daily during 3 weeks, fasting blood samples were taken.
HDL cholesterol increased by 18.2% (p<0.001) after beer compared to alcohol-free beer, while LDL cholesterol decreased by
7.8% (p=0.008). Lipoprotein-associated phospholipase A2 activity was not different (p=0.23) between beer (47.5±0.8) and alcohol-free beer (48.9±0.8). High-sensitive C-reactive protein was unaffected, but urinary isoprostanes tended
to increase (p=0.09) after beer (114.0±6.9) compared to alcohol-free beer (96.9±6.5). An interaction between BMI and treatment (p<0.05) on liver enzymes was observed, indicating an increase of liver enzymes after
moderate alcohol consumption in overweight men only.
Conclusion
Despite profound effects on HDL and LDL cholesterol, moderate alcohol consumption
did not affect lipoprotein-associated phospholipase A2 activity. Liver enzymes increased
after alcohol consumption in overweight men only, suggesting a less favorable response
to moderate alcohol consumption in overweight people.
Keywords
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Article info
Publication history
Published online: December 03, 2007
Accepted:
July 21,
2007
Received in revised form:
July 12,
2007
Received:
April 18,
2007
Identification
Copyright
© 2007 Published by Elsevier Inc.
