Abstract
Background and aims
Benefits of Mediterranean diet on MetS risk have been suggested, but overall prospective
evidence in the general population is limited. For the first time, the prospective
association of adherence to Mediterranean diet with the 6-y risk of MetS and its components
was evaluated in a large cohort in Europe.
Methods and results
Subjects included were participants from the Supplémentation en Vitamines et Minéraux
AntioXydants (SU.VI.MAX) study. Adherence to Mediterranean diet was assessed using
traditional Mediterranean diet score (MDS), an updated Mediterranean score (MED) and
Mediterranean style-dietary pattern score (MSDPS) calculated from at least three 24-h
records. In 3232 subjects, the association between Mediterranean diet scores and 6-y
risk of MetS was evaluated. The association between Mediterranean scores and MetS
components was also estimated. A lower risk of MetS was observed with increasing MED
score (P-trend = 0.001) and MDS (P-trend = 0.03) in multivariate models. The adjusted odds ratios (95% Confidence Interval)
for MetS risk were 0.47 (0.32–0.69) and 0.50 (0.32–0.77) in subjects in the highest
versus lowest tertile of MED score and MDS, respectively. The MED score was inversely
associated with waist circumference, systolic blood pressure and triglycerides, and
directly associated with HDL-cholesterol. The MDS was negatively associated with waist
circumference and triglycerides, and MSDPS was positively associated with HDL-cholesterol.
Conclusions
All Mediterranean diet scores were associated in a potentially beneficial direction
with components of MetS or MetS incidence. Our findings support that individuals should
be encouraged to follow a Mediterranean dietary pattern for reduction of MetS risk.
Trial Registration: clinicaltrials.gov Identifier: NCT00272428.
Keywords
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Article info
Publication history
Published online: May 28, 2012
Accepted:
February 14,
2012
Received in revised form:
February 14,
2012
Received:
October 13,
2011
Identification
Copyright
© 2012 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
