Abstract
Background and aims
Our recently published randomised clinical trial evaluated the effect of a low-calorie
diet with carbohydrates eaten at dinner. This dietary pattern led to lower hunger
scores, and better anthropometric, biochemical and inflammatory outcomes compared
to a standard low-calorie diet. In the same study, changes in diurnal secretion patterns
of leptin, ghrelin and adiponectin were investigated.
Methods and results
Seventy-eight police officers (body mass index (BMI) > 30) were randomly allocated
to experimental (carbohydrates at dinner) or control weight loss diets for 6 months.
Sixty-three subjects finished the programme. On days 0, 7, 90 and 180 blood samples
and hunger scores were collected every 4 h from 8:00 to 20:00. Hormonal profiles were
available for 39.
The dietary manipulation led to changes in daylight hormonal profiles in the experimental
group. Leptin's secretion curve became convex, with a nadir later in the day (significant
difference compared to baseline at morning and evening, p = 0.023, p = 0.021, respectively). Ghrelin's secretion curve became concave, peaking only in
the evening hours. Adiponectin's curve was elevated only after the experimental diet
(significant difference compared to baseline at afternoon, p = 0.044).
Conclusions
We propose that a low-calorie diet with carbohydrates eaten at dinner can modulate
daytime hormonal profiles. Taken together with our earlier results, we believe this
diet regime may prevent mid-day hunger, better support weight loss and improve metabolic
outcomes compared to conventional weight loss diets.
The trial is registered at controlled-trials.com, ISRCTN37829376, December 2009.
Keywords
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Article info
Publication history
Published online: August 16, 2012
Accepted:
April 19,
2012
Received in revised form:
April 5,
2012
Received:
November 23,
2011
Identification
Copyright
© 2012 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
