Highlights
- •We examined the effect of vitamin E alone or in combination with other antioxidants on myocardial infarction.
- •Vitamin E appears ineffective when associated with other antioxidants.
- •When supplemented alone vitamin E reduces myocardial infarction in interventional trials.
Abstract
Background and aims
Previous meta-analyses of interventional trials with vitamin E provided negative results
but it remains unclear if this vitamin has some influence on cardiovascular events
when supplemented alone. The aim of this study was to compare the effect of vitamin
E alone or in combination with other antioxidants on myocardial infarction.
Methods and results
Pubmed, ISI Web of Science, SCOPUS and Cochrane database were searched without language
restrictions. We investigated randomized clinical trials studying the effect of vitamin
E supplementation on myocardial infarction. Sixteen randomized controlled trials of
vitamin E treatment were analyzed in this meta-analysis. The dose range for vitamin
E was 33–800 IU. Follow-up ranged from 0.5 to 9.4 years. Compared to controls, vitamin E given
alone significantly decreased myocardial infarction (3.0% vs 3.4%) (random effects
R.R.: 0.82; 95% C.I., 0.70–0.96; p = 0.01). This effect was driven by reduction of
fatal myocardial infarction (random effects R.R.: 0.84; 95% C.I., 0.73–0.96; p = 0.01).
Conclusions
When supplemented alone, vitamin E reduces myocardial infarction in interventional
trials while it appears ineffective when associated with other antioxidants.
Keywords
Abbreviations:
ROS (reactive oxidant species), RCTs (randomized clinical trials)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: February 03, 2015
Accepted:
January 23,
2015
Received in revised form:
January 22,
2015
Received:
October 28,
2014
Footnotes
☆This review was conducted and reported according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) Statement.
Identification
Copyright
© 2015 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
