Highlights
- •Salba-chia is one of the highest food sources of dietary fiber, α-linolenic fat per total fat, rich in minerals, and protein.
- •Isocaloric supplementation of Salba-chia for 6 months demonstrated greater body weight reduction compared to control.
- •Supplementation of Salba-chia may be a promising addition to conventional therapy in the treatment of obesity in diabetes.
Abstract
Background and Aim
Preliminary findings indicate that consumption of Salba-chia (Salvia hispanica L.), an ancient seed, improves management of type 2 diabetes and suppresses appetite.
The aim of this study was to assesse the effect of Salba-chia on body weight, visceral
obesity and obesity-related risk factors in overweight and obese adults with type
2 diabetes.
Methods
A double-blind, randomized, controlled trial with two parallel groups involved 77
overweight or obese patients with type 2 diabetes (HbA1c: 6.5–8.0%; BMI: 25–40 kg/m2). Both groups followed a 6-month calorie-restricted diet; one group received 30 g/1000 kcal/day
of Salba-chia, the other 36 g/1000 kcal/day of an oat bran-based control. Primary
endpoint was change in body weight over 6-months. Secondary endpoints included changes
in waist circumference, body composition, glycemic control, C-reactive protein, and
obesity-related satiety hormones.
Results
At 6-months, participants on Salba-chia had lost more weight than those on control
(1.9 ± 0.5 kg and 0.3 ± 0.4 kg, respectively; P = 0.020), accompanied by a greater reduction in waist circumference (3.5 ± 0.7 cm
and 1.1 ± 0.7 cm, respectively; P = 0.027). C-reactive protein was reduced by 1.1 ± 0.5 mg/L (39 ± 17%) on Salba-chia,
compared to 0.2 ± 0.4 mg/L (7 ± 20%) on control (P = 0.045). Plasma adiponectin on the test intervention increased by 6.5 ± 0.7%, with
no change observed on control (P = 0.022).
Conclusions
The results of this study, support the beneficial role of Salba-chia seeds in promoting
weight loss and improvements of obesity related risk factors, while maintaining good
glycemic control. Supplementation of Salba-chia may be a useful dietary addition to
conventional therapy in the management of obesity in diabetes.
Registration
clinicaltrials.gov identifier: NCT01403571.
Keywords
Abbreviations:
ALA (alpha-linolenic acid), ALT (alanine aminotransferase), CVD (cardiovascular disease), DXA (dual energy X-ray absorptiometry), GLP-1 (glucagon-like peptide-1), Hs-CRP (high-sensitivity C-reactive protein), PT (prothrombin-time), T2DM (type 2 diabetes)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: December 08, 2016
Accepted:
November 29,
2016
Received in revised form:
October 25,
2016
Received:
May 12,
2016
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2016 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
