Highlights
- •The effects of fortified-yogurt (FY) on weight loss in overweight and obese patients with metabolic syndrome was assessed.
- •Consumption of FY resulted in a significant reduction in body fat mass, body fat percentage, waist circumference, HOMA-IR, triglyceride level, and a significant increase in 25(OH) D concentration, HDL-C and QUICKI compared to control plain yogurt.
- •Participants consuming the FY lost significantly less fat-free mass compared to the control plain yogurt.
Abstract
Background and Aims
Obesity is a complex and multifaceted condition. Thus, functional foods need investigation
as novel adjunct treatments for obesity. The objective was to determine the effects
of daily consumption of a fortified yogurt (FY) on weight loss in overweight and obese
patients with metabolic syndrome on a caloric-restricted diet.
Methods and Results
This was a randomized, double-blind, 10-week study. Participants were randomly allocated
to two groups receiving either two servings (2 × 250 g)/day of FY with whey protein,
calcium, vitamin D, prebiotic fibre and probiotic cultures (n = 44) or a low-fat plain
yogurt (PY) (n = 43). All participants were put on a calorie-restricted diet throughout
the 10-week study. Body composition and biochemical indices were assessed before and
after the intervention. Body mass decreased by 4.3 ± 1.9 kg and 5.1 ± 3.0 kg in the
PY and FY groups, respectively, following the 10-week intervention. Compared to PY,
consumption of FY resulted in a significant reduction in body fat mass (FM) (p = 0.023),
body fat percentage (p = 0.028), waist circumference (p = 0.002), homoeostasis model
of assessment-insulin resistance (HOMA-IR) (p = 0.025), triglyceride concentration
(p = 0.003), and a significant increase in total 25-hydroxyvitamin D (25(OH)D) concentration
(p < 0.001), high density lipoprotein-cholesterol (HDL-C) (p = 0.009) and quantitative
insulin sensitivity check index (QUICKI) (0.022). Participants consuming the FY lost
less fat-free mass (FFM) compared to the PY group (Δ = −0.9 ± 3.5 kg vs. Δ = −2.0 ± 2.7 kg;
p = 0.025).
Conclusions
Consuming FY for 10-weeks improved body composition and metabolic parameters, while
on a caloric-restricted diet. Further research is needed to elucidate whether FY can
be used as a preventative strategy for metabolic syndrome in obese persons.
Trial registration
www.irct.ir (IRCT2017050633836N1).
Keywords
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Article info
Publication history
Published online: March 09, 2018
Accepted:
March 4,
2018
Received in revised form:
February 27,
2018
Received:
December 3,
2017
Handling Editor: Peter CliftonIdentification
Copyright
© 2018 Published by Elsevier B.V. on behalf of The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University.
