Advertisement

Long-term effects of coffee and caffeine intake on the risk of pre-diabetes and type 2 diabetes: Findings from a population with low coffee consumption

Published:September 11, 2018DOI:https://doi.org/10.1016/j.numecd.2018.09.001

      Highlights

      • We assessed the possible associations of coffee and caffeine with the risk of diabetes and pre-diabetes.
      • A lower risk of pre-diabetes and diabetes was observed in coffee drinkers compared to non-drinkers.
      • Higher intake of caffeine (≥152 vs. <65 mg/d) was accompanied with a significant reduced risk of pre-diabetes.

      Abstract

      Background and aim

      Here, we examined the potential effect of coffee consumption and total caffeine intake on the occurrence of pre-diabetes and T2D, in a population with low coffee consumption.

      Methods and Results

      Adults men and women, aged 20–70 years, were followed for a median of 5.8 y. Dietary intakes of coffee and caffeine were estimated using a 168-food items validate semi-quantitative food frequency questionnaire, at baseline. Cox proportional hazards regression models, adjusted for potential cofounders, were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between coffee and caffeine intakes and incidence of pre-diabetes and T2D. The total population was 1878 adults (844 men, 1034 women) and 2139 adults (971 men, 1168 women) for analysis of pre-diabetes and T2D, respectively.
      During the follow-up period the incidence of pre-diabetes and T2D was 30.8% and 6.6%, respectively. Forty-three percent of our subjects were no coffee drinker whereas 51.4% consumed 1 cup of coffee/week and 6.0% consumed more than 1 cup of coffee/week. A lower risk of pre-diabetes (HR = 0.73, 95% CI = 0.62–0.86) and T2D (HR = 0.66, 95% CI = 0.44–1.00) was observed in coffee drinkers compared to non-drinkers, in the fully adjusted models. Higher dietary intake of caffeine (≥152 vs. <65 mg/d) was accompanied with a borderline (P = 0.053) reduced risk of pre-diabetes (HR = 0.45, 95% CI = 0.19–1.00).

      Conclusion

      Our findings indicated that coffee drinking may have favorable effect in prevention of pre-diabetes and T2D.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Nutrition, Metabolism and Cardiovascular Diseases
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Carlstrom M.
        • Larsson S.C.
        Coffee consumption and reduced risk of developing type 2 diabetes: a systematic review with meta-analysis.
        Nutr Rev. 2018; 76: 395-417
        • Pimentel G.D.
        • Zemdegs J.C.S.
        • Theodoro J.A.
        • Mota J.F.
        Does long-term coffee intake reduce type 2 diabetes mellitus risk?.
        Diabetol Metab Syndrome. 2009; 1: 6
        • van Dam R.M.
        • Willett W.C.
        • Manson J.E.
        • Hu F.B.
        Coffee, caffeine, and risk of type 2 diabetes: a prospective cohort study in younger and middle-aged U.S. women.
        Diabetes Care. 2006; 29: 398-403
        • Ding M.
        • Bhupathiraju S.N.
        • Chen M.
        • van Dam R.M.
        • Hu F.B.
        Caffeinated and decaffeinated coffee consumption and risk of type 2 diabetes: a systematic review and a dose-response meta-analysis.
        Diabetes Care. 2014; 37: 569-586
        • Jiang X.
        • Zhang D.
        • Jiang W.
        Coffee and caffeine intake and incidence of type 2 diabetes mellitus: a meta-analysis of prospective studies.
        Eur J Nutr. 2014; 53: 25-38
        • Yarmolinsky J.
        • Mueller N.T.
        • Duncan B.B.
        • Bisi Molina Mdel C.
        • Goulart A.C.
        • Schmidt M.I.
        Coffee Consumption, Newly Diagnosed Diabetes, and Other Alterations in Glucose Homeostasis: a Cross-Sectional Analysis of the Longitudinal Study of Adult Health (ELSA-Brasil).
        PLoS One. 2015; 10 (e0126469)
        • Azizi F.
        • Ghanbarian A.
        • Momenan A.A.
        • Hadaegh F.
        • Mirmiran P.
        • Hedayati M.
        • et al.
        Prevention of non-communicable disease in a population in nutrition transition: Tehran lipid and glucose study phase II.
        Trials. 2009; 10: 1-15
        • Azizi F.
        • Ghanbarian A.
        • Momenan A.A.
        • Hadaegh F.
        • Mirmiran P.
        • Hedayati M.
        • et al.
        Prevention of non-communicable disease in a population in nutrition transition: Tehran lipid and glucose study phase II.
        Trials. 2009; 10: 5
        • Momenan A.A.
        • Delshad M.
        • Sarbazi N.
        • Rezaei Ghaleh N.
        • Ghanbarian A.
        • Azizi F.
        Reliability and validity of the modifiable activity questionnaire (MAQ) in an Iranian urban adult population.
        Arch Iran Med. 2012; 15: 279-282
        • Hosseini-Esfahani F.
        • Jessri M.
        • Mirmiran P.
        • Bastan S.
        • Azizi F.
        Adherence to dietary recommendations and risk of metabolic syndrome: Tehran Lipid and Glucose Study.
        Metabol Clin Exp. 2010; 59: 1833-1842
        • Mirmiran P.
        • Esfahani F.H.
        • Mehrabi Y.
        • Hedayati M.
        • Azizi F.
        Reliability and relative validity of an FFQ for nutrients in the Tehran lipid and glucose study.
        Publ Health Nutr. 2010; 13: 654-662
      1. Diagnosis and classification of diabetes mellitus.
        Diabetes Care. 2010; 33: S62-S69
      2. Standards of medical care in diabetes--2014.
        Diabetes Care. 2014; 37: S14-S80
        • Bozorgmanesh M.
        • Hadaegh F.
        • Ghaffari S.
        • Harati H.
        • Azizi F.
        A simple risk score effectively predicted type 2 diabetes in Iranian adult population: population-based cohort study.
        Eur J Publ Health. 2011; 21: 554-559
        • Borai A.
        • Livingstone C.
        • Kaddam I.
        • Ferns G.
        Selection of the appropriate method for the assessment of insulin resistance.
        BMC Med Res Meth. 2011; 11: 158
        • Muniyappa R.
        • Lee S.
        • Chen H.
        • Quon M.J.
        Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usage.
        Am J Physiol Endocrinol Metab. 2008; 294: E15-E26
        • Iso H.
        • Date C.
        • Wakai K.
        • Fukui M.
        • Tamakoshi A.
        The relationship between green tea and total caffeine intake and risk for self-reported type 2 diabetes among Japanese adults.
        Ann Intern Med. 2006; 144: 554-562
        • van Dam R.M.
        Can 'omics' studies provide evidence for causal effects of coffee consumption on risk of type 2 diabetes?.
        J Intern Med. 2018; 283: 588-590
        • Palatini P.
        • Benetti E.
        • Mos L.
        • Garavelli G.
        • Mazzer A.
        • Cozzio S.
        • et al.
        Association of coffee consumption and CYP1A2 polymorphism with risk of impaired fasting glucose in hypertensive patients.
        Eur J Epidemiol. 2015; 30: 209-217
        • The C.
        • Caffeine Genetics C.
        • Cornelis M.C.
        • Byrne E.M.
        • Esko T.
        • Nalls M.A.
        • et al.
        Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption.
        Mol Psychiatr. 2014; 20: 647
        • Lee J.K.
        • Kim K.
        • Ahn Y.
        • Yang M.
        • Lee J.E.
        Habitual coffee intake, genetic polymorphisms, and type 2 diabetes.
        Eur J Endocrinol. 2015; 172: 595-601
        • Asghari G.
        • Rezazadeh A.
        • Hosseini-Esfahani F.
        • Mehrabi Y.
        • Mirmiran P.
        • Azizi F.
        Reliability, comparative validity and stability of dietary patterns derived from an FFQ in the Tehran Lipid and Glucose Study.
        Br J Nutr. 2012; 108: 1109-1117
        • Malmir H.
        • Shayanfar M.
        • Mohammad-Shirazi M.
        • Tabibi H.
        • Sharifi G.
        • Esmaillzadeh A.
        Tea and coffee consumption in relation to glioma: a case-control study.
        Eur J Nutr. 2017; ([Epub ahead of print])
        • Samadi S.
        • Baneshi M.R.
        • Haghdoost A.A.
        Pattern of alcohol consumption among men consumers in Kerman, Iran.
        Addiction Health. 2017; 9: 139-145