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Energy intake at different times of the day: Its association with elevated total and LDL cholesterol levels

Published:January 14, 2019DOI:https://doi.org/10.1016/j.numecd.2019.01.003

      Highlights

      • Distribution of energy intake (EI) during a day was associated with cholesterol levels.
      • Every 100 kcal additional EI at night was associated 1.08 mg/dL higher of LDL-cholesterol.
      • Replacing the EI at night by EI during the day was associated with lower total cholesterol.
      • Replacing the EI at night by EI during the day was associated with lower LDL-cholesterol.

      Abstract

      Background and aims

      This study examined the association between macronutrient intake at different times of the day and blood lipid levels.

      Methods and results

      The study was based on the Nutrition and Health Survey in Taiwan, a cross-sectional study of non-institutionalized and non-pregnant healthy adults (≥19-years-old). A one-day (24 h) dietary recall assessed participants’ food intake. Fasting plasma triglycerides, total cholesterol, and high-density lipoprotein (HDL) cholesterol were determined. Low-density lipoprotein (LDL) cholesterol was estimated based on the Friedewald formula. According to the data of eligible subjects (n = 1283), the time of energy intake was categorized into three meal times 0500–0929 (morning), 1130–1329 (noon), and 1730–2029 (evening), along with three snack times 0930–1129 (mid-morning), 1330–1729 (afternoon), and 2030–0459 (night). Energy and macronutrient intake were calculated for the 6 time periods, based on 24 h recall data. An adjusted regression model showed that by transferring 100 kcal intake at night to the morning or noon, LDL cholesterol would be lower by 1.46 (95% CI: 2.42–0.50) and 1.27 mg/dL (95% CI: 2.24–0.30), respectively. Transferring 100 kcal of fat intake at night to earlier periods was associated with a lower LDL cholesterol level, especially transferring to noontime (significantly lower by 5.21 mg/dL, 95% CI: [7.42–2.99]) and evening (significantly lower by 3.19 mg/dL, 95% CI: [6.29–0.08]).

      Conclusions

      Total cholesterol and LDL cholesterol had the same pattern of association with the timing of energy intake. The study showed that elevated total and LDL cholesterol were positively associated with nighttime energy and fat intake.

      Keywords

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      References

        • St-Onge M.P.
        • Ard J.
        • Baskin M.L.
        • Chiuve S.E.
        • Johnson H.M.
        • Kris-Etherton P.
        • et al.
        Meal timing and frequency: implications for cardiovascular disease prevention: a scientific statement from the American heart association.
        Circulation. 2017; 135: e96-e121
        • Chen H.J.
        • Wang Y.
        • Cheskin L.J.
        Relationship between frequency of eating and cardiovascular disease mortality in U.S. adults: the NHANES III follow-up study.
        Ann Epidemiol. 2016; 26: 527-533
        • Pot G.K.
        • Almoosawi S.
        • Stephen A.M.
        Meal irregularity and cardiometabolic consequences: results from observational and intervention studies.
        Proc Nutr Soc. 2016; 75: 475-486
        • Almoosawi S.
        • Vingeliene S.
        • Karagounis L.G.
        • Pot G.K.
        Chrono-nutrition: a review of current evidence from observational studies on global trends in time-of-day of energy intake and its association with obesity.
        Proc Nutr Soc. 2016; 75: 487-500
        • Hibi M.
        • Masumoto A.
        • Naito Y.
        • Kiuchi K.
        • Yoshimoto Y.
        • Matsumoto M.
        • et al.
        Nighttime snacking reduces whole body fat oxidation and increases LDL cholesterol in healthy young women.
        Am J Physiol Regul Integr Comp Physiol. 2013; 304: R94-R101
        • Maugeri A.
        • Kunzova S.
        • Medina-Inojosa J.R.
        • Agodi A.
        • Barchitta M.
        • Homolka M.
        • et al.
        Association between eating time interval and frequency with ideal cardiovascular health: results from a random sample Czech urban population.
        Nutr Metabol Cardiovasc Dis. 2018;
        • Almoosawi S.
        • Prynne C.J.
        • Hardy R.
        • Stephen A.M.
        Time-of-day and nutrient composition of eating occasions: prospective association with the metabolic syndrome in the 1946 British birth cohort.
        Int J Obes (Lond). 2013; 37: 725-731
        • Yusuf S.
        • Hawken S.
        • Ounpuu S.
        • Dans T.
        • Avezum A.
        • Lanas F.
        • et al.
        Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study.
        Lancet. 2004; 364: 937-952
        • Yoshizaki T.
        • Tada Y.
        • Hida A.
        • Sunami A.
        • Yokoyama Y.
        • Yasuda J.
        • et al.
        Effects of feeding schedule changes on the circadian phase of the cardiac autonomic nervous system and serum lipid levels.
        Eur J Appl Physiol. 2013; 113: 2603-2611
        • Bremner W.F.
        • Sothern R.B.
        • Kanabrocki E.L.
        • Ryan M.
        • McCormick J.B.
        • Dawson S.
        • et al.
        Relation between circadian patterns in levels of circulating lipoprotein(a), fibrinogen, platelets, and related lipid variables in men.
        Am Heart J. 2000; 139: 164-173
        • Rivera-Coll A.
        • Fuentes-Arderiu X.
        • Diez-Noguera A.
        Circadian rhythmic variations in serum concentrations of clinically important lipids.
        Clin Chem. 1994; 40: 1549-1553
        • van Kerkhof L.W.
        • Van Dycke K.C.
        • Jansen E.H.
        • Beekhof P.K.
        • van Oostrom C.T.
        • Ruskovska T.
        • et al.
        Diurnal variation of hormonal and lipid biomarkers in a molecular epidemiology-like setting.
        PLoS One. 2015; 10e0135652
        • Gooley J.J.
        Circadian regulation of lipid metabolism.
        Proc Nutr Soc. 2016; 75: 440-450
        • Romon M.
        • Le Fur C.
        • Lebel P.
        • Edme J.L.
        • Fruchart J.C.
        • Dallongeville J.
        Circadian variation of postprandial lipemia.
        Am J Clin Nutr. 1997; 65: 934-940
        • Tu S.H.
        • Chen C.
        • Hsieh Y.T.
        • Chang H.Y.
        • Yeh C.J.
        • Lin Y.C.
        • et al.
        Design and sample characteristics of the 2005–2008 nutrition and health survey in Taiwan.
        Asia Pac J Clin Nutr. 2011; 20: 225-237
        • Gerrior S.
        • Juan W.
        • Basiotis P.
        An easy approach to calculating estimated energy requirements.
        Prev Chronic Dis. 2006; 3: A129
        • Pan W.H.
        • Wu H.J.
        • Yeh C.J.
        • Chuang S.Y.
        • Chang H.Y.
        • Yeh N.H.
        • et al.
        Diet and health trends in Taiwan: comparison of two nutrition and health surveys from 1993–1996 and 2005–2008.
        Asia Pac J Clin Nutr. 2011; 20: 238-250
        • Wu S.J.
        • Pan W.H.
        • Yeh N.H.
        • Chang H.Y.
        Trends in nutrient and dietary intake among adults and the elderly: from NAHSIT 1993–1996 to 2005–2008.
        Asia Pac J Clin Nutr. 2011; 20: 251-265
        • Friedewald W.T.
        • Levy R.I.
        • Fredrickson D.S.
        Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge.
        Clin Chem. 1972; 18: 499-502
        • Chau C.A.
        • Pan W.H.
        • Chen H.J.
        Employment status and temporal patterns of energy intake: nutrition and Health Survey in Taiwan, 2005–2008.
        Publ Health Nutr. 2017; 20: 3295-3303
        • Hu F.
        Assessment of physical activity in nutritional epidemiology.
        in: Willett W. Nutritional epidemiology. 3rd ed. Oxford University Press, New York, USA2012
        • Garaulet M.
        • Gomez-Abellan P.
        • Alburquerque-Bejar J.J.
        • Lee Y.C.
        • Ordovas J.M.
        • Scheer F.A.
        Timing of food intake predicts weight loss effectiveness.
        Int J Obes (Lond). 2013; 37: 604-611
        • Ruiz-Lozano T.
        • Vidal J.
        • de Hollanda A.
        • Scheer F.
        • Garaulet M.
        • Izquierdo-Pulido M.
        Timing of food intake is associated with weight loss evolution in severe obese patients after bariatric surgery.
        Clin Nutr. 2016; 35: 1308-1314
        • Fernandez M.L.
        • West K.L.
        Mechanisms by which dietary fatty acids modulate plasma lipids.
        J Nutr. 2005; 135: 2075-2078
        • Woollett L.A.
        • Spady D.K.
        • Dietschy J.M.
        Mechanisms by which saturated triacylglycerols elevate the plasma low density lipoprotein-cholesterol concentration in hamsters. Differential effects of fatty acid chain length.
        J Clin Invest. 1989; 84: 119-128
        • Hussain M.M.
        • Pan X.
        Circadian regulators of intestinal lipid absorption.
        J Lipid Res. 2015; 56: 761-770
        • Galman C.
        • Angelin B.
        • Rudling M.
        Bile acid synthesis in humans has a rapid diurnal variation that is asynchronous with cholesterol synthesis.
        Gastroenterology. 2005; 129: 1445-1453
        • Jones P.J.
        • Schoeller D.A.
        Evidence for diurnal periodicity in human cholesterol synthesis.
        J Lipid Res. 1990; 31: 667-673
        • Arasaradnam M.P.
        • Morgan L.
        • Wright J.
        • Gama R.
        Diurnal variation in lipoprotein lipase activity.
        Ann Clin Biochem. 2002; 39: 136-139
        • Persson L.
        • Cao G.
        • Stahle L.
        • Sjoberg B.G.
        • Troutt J.S.
        • Konrad R.J.
        • et al.
        Circulating proprotein convertase subtilisin kexin type 9 has a diurnal rhythm synchronous with cholesterol synthesis and is reduced by fasting in humans.
        Arterioscler Thromb Vasc Biol. 2010; 30: 2666-2672
        • McKenney J.M.
        Understanding PCSK9 and anti-PCSK9 therapies.
        J Clin Lipidol. 2015; 9: 170-186
        • Marrino P.
        • Gavish D.
        • Shafrir E.
        • Eisenberg S.
        Diurnal variations of plasma lipids, tissue and plasma lipoprotein lipase, and VLDL secretion rates in the rat. A model for studies of VLDL metabolism.
        Biochim Biophys Acta. 1987; 920: 277-284
        • Pan X.
        • Hussain M.M.
        Diurnal regulation of microsomal triglyceride transfer protein and plasma lipid levels.
        J Biol Chem. 2007; 282: 24707-24719
        • Balasubramaniam S.
        • Szanto A.
        • Roach P.D.
        Circadian rhythm in hepatic low-density-lipoprotein (LDL)-receptor expression and plasma LDL levels.
        Biochem J. 1994; 298: 39-43