Research Article| Volume 29, ISSUE 11, P1185-1188, November 2019

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No association between coffee consumption and risk of atrial fibrillation: A Mendelian randomization study

  • Shuai Yuan
    Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden

    Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
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  • Susanna C. Larsson
    Corresponding author. Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Nobelsväg 13, Stockholm, 17177, Sweden.
    Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden

    Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
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      • Whether coffee consumption is causally associated with risk of atrial fibrillation is unknown.
      • This study based on genetics found no association between coffee consumption and atrial fibrillation.
      • Coffee consumption will unlikely increase or decrease the risk of atrial fibrillation.


      Background and aims

      Some observational studies have found that habitual coffee and caffeine consumption might reduce the risk of atrial fibrillation (AF). We conducted a two-sample Mendelian randomization study to explore the potential association between coffee consumption and AF.

      Methods and results

      This study was based on summary-level data from the Atrial Fibrillation Consortium, including 588 190 individuals (65 446 cases and 522 744 non-cases). Nine single-nucleotide polymorphisms associated with coffee consumption at significance level of P < 5 × 10−8 were used as instrumental variables and were obtained from a genome-wide association study that included up to 375 833 individuals.
      The odds ratio of AF per genetically-predicted 50% increase of coffee consumption was 0.98 (95% confidence interval, 0.88, 1.10; P = 0.80) in the standard inverse-variance weighted analysis. Results were consistent in sensitivity analyses using the weighted median and MR-Egger methods, and no directional pleiotropy (P = 0.37) was observed. Moreover, complementary analyses that separated the coffee-related single-nucleotide polymorphisms based on their association with blood levels of caffeine metabolites (lower, higher, unrelated or unknown association) revealed no association with AF.


      This study does not support a causal association between habitual coffee consumption and risk of AF.


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