Systematic Reviews and Meta-analyses| Volume 30, ISSUE 12, P2159-2170, November 27, 2020

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Effect of coffee consumption on dyslipidemia: A meta-analysis of randomized controlled trials


      • This is the latest study that systematically explores the effects of coffee consumption on blood lipid.
      • The results showed that coffee consumption significantly increased TC, TG and LDL-C while had no significant effect on HDL-C.
      • Dose–response analysis results revealed a positive nonlinear relation between coffee consumption and TC, LDL-C and TG changes.
      • This meta-analysis suggested that coffee consumption may be associated with an elevated risk for dyslipidemia and CVDs.


      Background and aim

      Dyslipidemia is a common metabolic disease worldwide and also an important predisposing factor for cardiovascular diseases (CVDs). Coffee is loved by people all over the world; however, the association between coffee consumption and blood lipids has yielded inconsistent results. So we carried this meta-analysis to explore the effects of coffee consumption on blood lipids.

      Methods and results

      Medline, PubMed, Web of science, Embase, and Cochrane Library databases were systematically searched until April 2020. Combined weighted mean differences (WMD) with their 95% confidence interval (CI) were calculated using random-effects models, and between-study heterogeneity was assessed by Cochran's Q test and I2 statistics. Subgroup analysis and meta-regression analysis were also conducted to explore the potential heterogeneity. A total of 12 RCT studies involving the association between coffee consumption and blood lipid levels were included in the meta-analysis. The pooled results showed that coffee consumption significantly increased total cholesterol (TC) (WMD: 0.21 mmol/L, 95% CI: 0.04; 0.39, P = 0.017), triglyceride (TG) (WMD: 0.12 mmol/L, 95% CI: 0.03; 0.20, P = 0.006) and low-density lipoprotein (LDL-C) (WMD: 0.14 mmol/L, 95% CI: 0.05; 0.24, P = 0.003) while had no significant effect on high-density lipoprotein (HDL-C) (WMD: −0.01 mmol/L, 95% CI: −0.06; 0.04, P = 0.707). Dose–response analysis results revealed significant positive nonlinear associations between coffee consumption and the increase in TC, LDL-C, and TG levels.


      Evidence from this meta-analysis suggested that coffee consumption may be associated with an elevated risk for dyslipidemia and CVDs. So a reasonable habit of coffee consumption (<3 cups/d) is essential for the prevention of dyslipidemia.


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        • Organization W.H.
        Cardiovascular disease (CVDs).
        • Smith D.G.
        Epidemiology of dyslipidemia and economic burden on the healthcare system.
        Am J Manag Care. 2007; 13: S68
        • Karam I.
        • Ma N.
        • Liu X.W.
        • Li S.H.
        • Kong X.J.
        • Li J.Y.
        • et al.
        Regulation effect of Aspirin Eugenol Ester on blood lipids in Wistar rats with hyperlipidemia.
        BMC Vet Res. 2015; 11: 217
        • Rouhani M.H.
        • Rashidi-Pourfard N.
        • Salehi-Abargouei A.
        • Karimi M.
        • Haghighatdoost F.
        Effects of egg consumption on blood lipids: a systematic review and meta-analysis of randomized clinical trials.
        J Am Coll Nutr. 2017; : 1-12
        • Bhandari S.
        • Gupta P.
        • Quinn P.
        • Sandhu J.
        • Ng L.
        Pleiotropic effects of statins in hypercholesterolaemia: a prospective observational study using a lipoproteomic based approach.
        Lancet. 2015; 385: S21
        • Koene R.J.
        • Prizment A.E.
        • Blaes A.
        • Konety S.H.
        Shared risk factors in cardiovascular disease and cancer.
        Circulation. 2016; 133: 1104-1114
        • Nordestgaard B.G.
        • Varbo A.
        Triglycerides and cardiovascular disease.
        Lancet. 2014; 384: 626-635
        • Perk J.
        • De Backer G.
        • Gohlke H.
        • Graham I.
        • Reiner Ž.
        • Verschuren W.M.
        • et al.
        European Guidelines on cardiovascular disease prevention in clinical practice (version 2012).
        Int J Behav Med. 2012; 19: 403-488
        • Butt M.S.
        • Sultan M.T.
        Coffee and its consumption: benefits and risks.
        Crit Rev Food Sci Nutr. 2011; 51: 363-373
        • Higdon J.V.
        • Frei B.
        Coffee and health: a review of recent human research.
        Crit Rev Food Sci Nutr. 2006; 46: 101-123
        • Micek A.
        • Gniadek A.
        • Kawalec Paweł
        • Brzostek T.
        Coffee consumption and colorectal cancer risk: a dose-response meta-analysis on prospective cohort studies.
        Int J Food Sci Nutr. 2019; : 1-21
        • Giuseppe Grosso
        • Agnieszka Micek
        • Justyna Godos
        • Andrzej Pajak
        • Salvatore Sciacca
        • Maira Bes-Rastrollo
        • et al.
        Long-term coffee consumption is associated with decreased incidence of new-onset hypertension: a dose–response meta-analysis.
        Nutrients. 2017; 9: 890
        • Hartley T.R.
        • Lovallo W.R.
        • Whitsett T.L.
        Cardiovascular effects of caffeine in men and women.
        Am J Cardiol. 2004; 93: 1022-1026
        • Jee S.H.
        • He J.
        • Appel L.J.
        • Whelton P.K.
        • Suh Il
        • Klag M.J.
        Coffee consumption and serum lipids: a meta-analysis of randomized controlled clinical trials.
        Am J Epidemiol. 2001; 153: 353-362
        • Rustan A.C.
        • Halvorsen B.
        • Huggett A.C.
        • Ranheim T.
        • Drevon C.A.
        Effect of coffee lipids (cafestol and kahweol) on regulation of cholesterol metabolism in HepG2 cells.
        Arterioscler Thromb Vasc Biol. 1997; 17: 2140-2149
        • Jiang X.
        • Zhang D.
        • Jiang W.
        Coffee and caffeine intake and incidence of type 2 diabetes mellitus: a meta-analysis of prospective studies.
        Eur J Nutr. 2014; 53: 25-38
        • Kempf K.
        • Herder C.
        • Erlund I.
        • Kolb H.
        • Martin S.
        • Carstensen M.
        • et al.
        Effects of coffee consumption on subclinical inflammation and other risk factors for type 2 diabetes: a clinical trial.
        Am J Clin Nutr. 2010; 4: 950-957
        • Roshan H.
        • Nikpayam O.
        • Sedaghat M.
        • Sohrab G.
        Effects of green coffee extract supplementation on anthropometric indices, glycaemic control, blood pressure, lipid profile, insulin resistance and appetite in patients with the metabolic syndrome: a randomised clinical trial.
        Br J Nutr. 2018; : 1-9
        • Agudelo-Ochoa G.M.
        • Pulgarin-Zapata I.C.
        • Velasquez-Rodriguez C.M.
        • Duque-Ramirez M.
        • Naranjo-Cano M.
        • Quintero-Ortiz M.M.
        • et al.
        Coffee consumption increases the antioxidant capacity of plasma and has no effect on the lipid profile or vascular function in healthy adults in a randomized controlled trial.
        J Nutr. 2016; (jn.115.224774)
        • Shamseer L.
        • Moher D.
        • Clarke M.
        • Ghersi D.
        • Liberati A.
        • Petticrew M.
        Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation.
        BMJ. 2015; 349: g7647
        • Wang F.
        • Zheng J.
        • Yang B.
        • Jiang J.
        • Fu Y.
        • Li D.
        Effects of vegetarian diets on blood lipids: a systematic review and meta-analysis of randomized controlled trials.
        J Am Heart Assoc. 2015; 4e002408
        • Higgins J.
        • Altman D.G.
        • Gøtzsche P.C.
        • Jüni P.
        • Moher D.
        • Oxman A.D.
        • et al.
        The Cochrane Collaboration's tool for assessing risk of bias in randomised trials.
        Br Med J. 2011; 343: d5928
        • Elbourne D.R.
        • Altman D.G.
        • Higgins J.P.
        • Curtin F.
        • Worthington H.V.
        • Vail A.
        Meta-analyses involving cross-over trials: methodological issues.
        Int J Epidemiol. 2002; 31: 140-149
        • Egger M.
        • Davey Smith G.
        • Schneider M.
        • Minder C.
        Bias in meta-analysis detected by a simple, graphical test.
        BMJ (Clinical research ed.). 1997; 315: 629-634
        • Christensen B.
        • Annhild M.
        • Lars R.
        • Sverre L.
        • Thelle D.S.
        Abstention from filtered coffee reduces the concentrations of plasma homocysteine and serum cholesterol—a randomized controlled trial.
        Am J Clin Nutr. 2001; 74: 302-307
        • D'Amicis A.
        • Scaccini C.
        • Tomassi G.
        • Anaclerio M.
        • Stornelli R.
        • Bernini A.
        Italian style brewed coffee: effect on serum cholesterol in young men.
        Int J Epidemiol. 1996; 25: 513-520
        • Burr M.L.
        • Limb E.S.
        • Sweetnam P.M.
        • Fehily A.M.
        • Amarah L.
        • Hutchings A.
        Instant coffee and cholesterol: a randomised controlled trial.
        Eur J Clin Nutr. 1995; 49: 779-784
        • Fried R.E.
        • Levine D.M.
        • Kwiterovich P.O.
        • Diamond E.L.
        • Pearson T.A.
        The effect of filtered-coffee consumption on plasma lipid levels: results of a randomized clinical trial.
        JAMA. 1992; 267: 811-815
        • Superko H.R.
        • Bortz W.
        • Williams P.T.
        • Albers J.J.
        • Wood P.D.
        Caffeinated and decaffeinated coffee effects on plasma lipoprotein cholesterol, apolipoproteins, and lipase activity: a controlled, randomized trial.
        Am J Clin Nutr. 1991; 54: 599-605
        • van Dusseldorp M.
        • Katan M.B.
        • van Vliet T.
        • Demacker P.N.
        • Stalenhoef A.F.
        Cholesterol-raising factor from boiled coffee does not pass a paper filter.
        Arterioscler Thromb. 1991; 11: 586-593
        • Rosmarin P.C.
        • Applegate W.B.
        • Somes G.W.
        Coffee consumption and serum lipids: a randomized, crossover clinical trial.
        Am J Med. 1990; 88: 349-356
        • Burr M.L.
        • Gallacher J.E.
        • Butland B.K.
        • Bolton C.H.
        • Downs L.G.
        Coffee, blood pressure and plasma lipids: a randomized controlled trial.
        Eur J Clin Nutr. 1989; 43: 477-483
        • Bak A.A.A.
        • Grobbee D.E.
        The effect on serum cholesterol levels of coffee brewed by filtering or boiling.
        N Engl J Med. 1989; 321: 1432-1437
        • Aro A.
        • Kostiainen E.
        • Huttunen J.K.
        • Seppälä E.
        • Vapaatalo H.
        Effects of coffee and tea on lipoproteins and prostanoids.
        Atherosclerosis. 1985; 57: 123-128
        • Cai L.
        • Ma D.
        • Zhang Y.
        • Liu Z.
        • Wang P.
        The effect of coffee consumption on serum lipids: a meta-analysis of randomized controlled trials.
        Eur J Clin Nutr. 2012; 66: 872-877
        • Miyake Y.
        • Kono S.
        • Nishiwaki M.
        • Hamada H.
        • Nishikawa H.
        • Koga H.
        • et al.
        Relationship of coffee consumption with serum lipids and lipoproteins in Japanese men.
        Ann Epidemiol. 1999; 9: 121-126
        • Brown C.A.
        • Bolton-Smith C.
        • Woodward M.
        • Tunstall-Pedoe H.
        Coffee and tea consumption and the prevalence of coronary heart disease in men and women: results from the scottish heart health study.
        J Epidemiol Community Health. 1993; 47: 171-175
        • Silvério Alessandra dos Santos Danziger
        • Pereira Rosemary Gualberto Fonseca Alvarenga
        • Lima Adriene Ribeiro
        • de Araújo Paula Fernanda Borges
        • Rodrigues Maria Rita
        • Baldissera Jr., Lineu
        • et al.
        The effects of the decaffeination of coffee samples on platelet aggregation in hyperlipidemic rats.
        Plant Foods Hum Nutr (Dordr). 2013; 68: 268-273
        • Aro A.
        • Teirilä J.
        • Gref C.G.
        Dose-dependent effect on serum cholesterol and apoprotein B concentrations by consumption of boiled, non-filtered coffee.
        Atherosclerosis. 1990; 83: 257-261
        • Urgert R.
        • Katan M.B.
        The cholesterol-raising factor from coffee beans.
        J R Soc Med. 1996; 89: 618-623
        • Jossa F.
        • Krogh V.
        • Farinaro E.
        • Panico S.
        • Trevisan M.
        Coffee and serum lipids: findings from the Olivetti Heart Study.
        Ann Epidemiol. 1993; 3: 250-255
        • Wahrburg U.
        • Martin H.
        • Schulte H.
        • Walek T.
        • Assmann G.
        Effects of two kinds of decaffeinated coffee on serum lipid profiles in healthy young adults.
        Eur J Clin Nutr. 1994; 48: 172-179
        • Lee C.
        Antioxidant ability of caffeine and its metabolites based on the study of oxygen radical absorbing capacity and inhibition of LDL peroxidation.
        Clin Chim Acta. 2000; 295: 141-154
        • Meng S.
        • Cao J.
        • Feng Q.
        • Peng J.
        • Hu Y.
        Roles of chlorogenic acid on regulating glucose and lipids metabolism: a review.
        Evid Based Complement Alternat Med. 2013; : 1-11
        • Cho A.S.
        • Jeon S.M.
        • Kim M.J.
        • Yeo J.
        • Seo K.I.
        • Choi M.S.
        • et al.
        Chlorogenic acid exhibits anti-obesity property and improves lipid metabolism in high-fat diet-induced-obese mice.
        Food Chem Toxicol. 2010; 48: 937-943
        • Ong K.W.
        • Hsu A.
        • Tan B.K.H.
        Anti-diabetic and anti-lipidemic effects of chlorogenic acid are mediated by ampk activation.
        Biochem Pharmacol. 2013; 85: 1341-1351
        • Ma Y.
        • Gao M.
        • Liu D.
        Chlorogenic acid improves high fat diet-induced hepatic steatosis and insulin resistance in mice.
        Pharmaceut Res. 2015; 32: 1200-1209
        • Nilsson L.M.
        • Wennberg M.
        • Lindahl B.
        • Eliasson M.
        • Guelpen B.V.
        Consumption of filtered and boiled coffee and the risk of first acute myocardial infarction; a nested case/referent study.
        Nutr Metabol Cardiovasc Dis. 2009; 20: 527-535
        • Post S.M.
        Cafestol increases serum cholesterol levels in apolipoprotein Eˆ∗3-leiden transgenic mice by suppression of bile acid synthesis.
        Arterioscler Thromb Vasc Biol. 2000; 20: 1551-1556