- WHO EMRO
- Lee A.H.
- Dixit V.D.
- Delcuve G.P.
- Lakowski T.M.
- Su R.C.
- Beacon T.H.
- Davie J.R.
- Beacon T.H.
- Su R.C.
- Lakowski T.M.
- Delcuve G.P.
- Davie J.R.
- Pilz S.
- Zittermann A.
- Trummer A.
- Theiler-Schwetz V.
- Lerchbaum E.
- Keppel M.H.
- et al.
- Wu D.
- Lewis E.D.
- Pae M.
- Meydani S.N.
- Prietl B.
- Treiber G.
- Pieber T.R.
- Amrein K.
- Charoenngam N.
- Holick M.F.
- Hirsch D.
- Archer F.E.
- Joshi-Kale M.
- Vetrano A.M.
- Weinberger B.
- Felsenstein S.
- Herbert J.A.
- McNamara P.S.
- Hedrich C.M.
- Melenotte C.
- Silvin A.
- Goubet A.G.
- Lahmar I.
- Dubuisson A.
- Zumla A.
- et al.
- Sassi F.
- Tamone C.
- D'Amelio P.
- Quesada-Gomez J.M.
- Entrenas-Castillo M.
- Bouillon R.
|Maghbooli et al.|
PLOS ONE, 2020 [
|In 235 hospitalised patients vitamin D sufficiency was statistically associated with a lower risk of unconsciousness (p = 0.03) and hypoxia (p = 0.004), a lower C-reactive protein blood level (p = 0.01) and a higher blood lymphocyte percentage (p = 0.03). Moreover, in a logistic regression model, vitamin D sufficiency was independently associated with decreased disease severity.|
|Entrenas Castillo et al.|
J Steroid Biochem and Mol Biol, 2020 [
Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: a pilot randomized clinical study.
J Steroid Biochem Mol Biol. 2020; 203: 105751https://doi.org/10.1016/j.jsbmb.2020.105751
|Among 76 hospitalised patients (50 with and 26 without Calcifediol treatment) 98% of the patients on calcifediol did not require Intensive Care Unit versus only 50% of the patients not treated with Calcifediol (p < 0.001).|
|Ilie et al.|
Aging Clin. Exp. Res, 2020 [
|In European countries: a) inverse correlation between average vitamin D level and number of COVID-19 cases per million population r = − 0.44; p = 0.050]; b) inverse correlation between average vitamin D level and number of COVID-19 related deaths per million, r = − 0.43; p = 0.050).|
|D'Avolio et al.|
Nutrients, 2020 [
|By retrospective analysis of 107 patients undergoing a nasopharyngeal swab with PCR analysis for SARS-CoV-2 and concomitant serum 25(OH)D measurement, lower 25(OH)D levels (11.1 ng/mL) were found in patients positive to SARS-CoV-2 compared with negative patients (24.6 ng/mL), p = 0.004).|
|Panagiotou, Clinical Endocrinology, 2020 [||The analysis of 134 Covid-19 hospitalised patients showed that 66.4% were vitamin D insufficient and 37.3% were vitamin D deficient (21.6% severely deficient). Moreover, patients admitted to Intensive Therapy Unit (ITU) had a lower 25(OH)D level compared with non-ITU patients despite being younger (p = 0.02).|
- Lips P.
- Cashman K.D.
- Lamberg-Allardt C.
- Bischoff-Ferrari H.A.
- Obermayer-Pietsch B.
- Bianchi M.L.
- et al.
- Bouillon R.
- Marcocci C.
- Carmeliet G.
- Bikle D.
- White J.H.
- Dawson-Hughes B.
- et al.
- Elijovich F.
- Laffer C.L.
- Sahinoz M.
- Pitzer A.
- Ferguson J.F.
- Kirabo A.
- Afshar M.
- Richards S.
- Mann D.
- Cross A.
- Smith G.B.
- Netzer G.
- et al.
- Baum M.
- Rafie C.
- Lai S.
- Sales S.
- Bryan Page J.
- Campa A.
- Bhattacharya R.
- Shuhart M.
Declaration of competing interest
- Nutrition advice for adults during the COVID-19 outbreak.http://www.emro.who.int/nutrition/nutrition-infocus/nutrition-advice-for-adults-during-the-covid-19-outbreak.htmlDate accessed: September 30, 2020
- Optimal nutritional status for a well-functioning immune system is an important factor to protect against viral infections.Nutrients. 2020; 12: 1181https://doi.org/10.3390/nu12041181
- Dietary regulation of immunity.Immunity. 2020; 53: 510-523https://doi.org/10.1016/j.immuni.2020.08.013
- SARS-CoV-2 multifaceted interaction with human host. Part I: what we have learn.IUBMB Life. 2020; : 1-18https://doi.org/10.1002/iub.2380
- SARS-CoV-2 multifaceted interaction with the human host. Part II: innate immunity response, immunopathology, and epigenetics.IUBMB Life. 2020; : 1-24https://doi.org/10.1002/iub.2379
- Immune organs and immune cells on a chip: an overview of biomedical applications.Micromachines. 2020; 11: E849https://doi.org/10.3390/mi11090849
- Vitamin D testing and treatment: a narrative review of current evidence.Endocr Connect. 2019; 8: R27-R43https://doi.org/10.1530/EC-18-0432
- Nutritional modulation of immune function: analysis of evidence, mechanisms, and clinical relevance.Front Immunol. 2019; 9: 3160https://doi.org/10.3389/fimmu.2018.03160
- Effects of vitamin D on the peripheral adaptive immune system: a review.Autoimmun Rev. 2011; 10: 733-743
- Vitamin D: a narrative review examining the evidence for ten beliefs.J Gen Intern Med. 2016; 31: 780-791
- Vitamin D and immune function.Nutrients. 2013; 5: 2502-2521https://doi.org/10.3390/nu5072502
- Immunologic effects of vitamin D on human health and disease.Nutrients. 2020; 12: 2097https://doi.org/10.3390/nu12072097
- Decreased anti-inflammatory responses to vitamin D in neonatal neutrophils.Mediators Inflamm. 2011; : 598345https://doi.org/10.1155/2011/598345
- Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response.Science. 2006; 311: 1770-1773
- Regulation of immune function by vitamin D and its use in diseases of immunity.Endocrinol Metab Clin N Am. 2017; 46: 1061-1094
- COVID-19: immunology and treatment options.Clin Immunol. 2020; 215: 108448https://doi.org/10.1016/j.clim.2020.108448
- Immune responses during COVID-19 infection.Oncoimmunology. 2020; 9: 1807836https://doi.org/10.1080/2162402X.2020.1807836
- Vitamin D deficiency is associated with inflammation in older Irish adults.J Clin Endocrinol Metab. 2014; 99: 1807-1815
- Vitamin D: nutrient, hormone, and immunomodulator.Nutrients. 2018; 10: 1656https://doi.org/10.3390/nu10111656
- Vitamin D receptor stimulation to reduce acute respiratory distress syndrome (ARDS) in patients with coronavirus SARS-CoV-2 infections: Revided Ms SBMB 2020_166.J Steroid Biochem Mol Biol. 2020; 202: 105719https://doi.org/10.1016/j.jsbmb.2020.105719
- Vitamin D sufficiency, a serum 25-hydroxyvitamin D at least 30 ng/mL reduced risk for adverse clinical outcomes in patients with COVID-19 infection.PloS One. 2020; 15e0239799https://doi.org/10.1371/journal.pone.0239799
- Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: a pilot randomized clinical study.J Steroid Biochem Mol Biol. 2020; 203: 105751https://doi.org/10.1016/j.jsbmb.2020.105751
- The role of vitamin D in the prevention of coronavirus disease 2019 infection and mortality.Aging Clin Exp Res. 2020; 32: 1195-1198https://doi.org/10.1007/s40520-020-01570-8
- 25-Hydroxyvitamin D concentrations are lower in patients with positive PCR for SARS-CoV-2.Nutrients. 2020; 12: 1359https://doi.org/10.3390/nu12051359
- Low serum 25-hydroxyvitamin D (25[OH]D) levels in patients hospitalized with COVID-19 are associated with greater disease severity.Clin Endocrinol. 2020; 93: 508-514https://doi.org/10.1111/cen.14276
- Current vitamin D status in European and Middle East countries and strategies to prevent vitamin D deficiency: a position statement of the European Calcified Tissue Society.Eur J Endocrinol. 2019; 180: P23-P54https://doi.org/10.1530/EJE-18-0736
- Skeletal and extraskeletal actions of vitamin D: current evidence and outstanding questions.Endocr Rev. 2019; 40: 1109-1151https://doi.org/10.1210/er.2018-00126
- Vitamin D deficiency 2.0: an update on the current status worldwide.Eur J Clin Nutr. 2020 Jan 20; : 1-16https://doi.org/10.1038/s41430-020-0558-y
- Salt intake, stroke, and cardiovascular disease: meta-analysis of prospective studies.BMJ. 2009; 339: b4567
- The role of sodium in modulating immune cell function.Nat Rev Nephrol. 2019; 15: 546-558
- Na magnetic resonance imaging determined tissue sodium in healthy subjects and hypertensive patients.Hypertension. 2013; 61: 635-640
- Glycosaminoglycan polymerization may enable osmotically inactive Na+ storage in the skin.Am J Physiol Heart Circ Physiol. 2004; 287: H203-H208
- Salt- dependent chemotaxis of macrophages.PloS One. 2013; 8e73439
- Macrophages regulate salt- dependent volume and blood pressure by a vascular endothelial growth factor- C-dependent buffering mechanism.Nat Med. 2009; 15: 545-552
- High salt reduces the activation of IL-4- and IL-13-stimulated macrophages.J Clin Invest. 2015; 125: 4223-4238
- Cutaneous Na+ storage strengthens the antimicrobial barrier function of the skin and boosts macrophage- driven host defense.Cell Metabol. 2015; 21: 493-501
- High salt primes a specific activation state of macrophages, M(Na).Cell Res. 2015; 25: 893-910
- Immunological decision-making: how does the immune system decide to mount a helper T cell response?.Immunology. 2008; 123: 326-338
- Induction of pathogenic TH17 cells by inducible salt- sensing kinase SGK1.Nature. 2013; 496: 513-517
- Inflammatory effects of ex vivo human Th17 cells are suppressed by regulatory T cells.J Immunol. 2010; 185: 3199-3208
- Sodium chloride inhibits the suppressive function of FOXP3+regulatory T cells.J Clin Invest. 2015; 125: 4212-4222
- The gut microbiome, inflammation, and salt-sensitive hypertension.Curr Hypertens Rep. 2020; 22: 79https://doi.org/10.1007/s11906-020-01091-9
- Salt- responsive gut commensal modulates TH17 axis and disease.Nature. 2017; 551: 585-589
- Dietary salt promotes neurovascular and cognitive dysfunction through a gut- initiatedTH17 response.Nat Neurosci. 2018; 21: 240-249
- Sodium, hypertension, and the gut: does the gut microbiota go salty?.Am J Physiol Heart Circ Physiol. 2019; 317: H1173-H1182https://doi.org/10.1152/ajpheart.00312.2019
- Acute immunomodulatory effects of binge alcohol ingestion.Alcohol. 2015; 49: 57-64https://doi.org/10.1016/j.alcohol.2014.10.002
- Ethanol suppresses cytokine responses induced through Toll-like receptors as well as innate resistance to Escherichia coli in a mouse model for binge drinking.Alcohol. 2004; 33: 147-155https://doi.org/10.1016/j.alcohol.2004.08.001
- The opposite effects of acute and chronic alcohol on lipopolysaccharide-induced inflammation are linked to IRAK-M in human monocytes.J Immunol. 2009; 183: 1320-1327
- Inhibition of TLR8- and TLR4-induced Type I IFN induction by alcohol is different from its effects on inflammatory cytokine production in monocytes.BMC Immunol. 2011; 12: 55
- Chronic ethanol feeding modulates inflammatory mediators, activation of nuclear factor-kappaB, and responsiveness to endotoxin in murine Kupffer cells and circulating leukocytes.Mediators Inflamm. 2014; 2014: 808695
- Opposing effects of alcohol on the immune system.Prog Neuro-Psychopharmacol Biol Psychiatry. 2016; 65: 242-251
- Abnormal leukocyte response in alcoholism.Ann Intern Med. 1963; 59: 865-877
- The associations of alcohol drinking and drinking cessation to measures of the immune system in middle-aged men.Alcohol Clin Exp Res. 1992; 16: 688-694
- Fine T-cell subsets in alcoholics as determined by the expression of L-selectin, leukocyte common antigen, and beta-integrin.Alcohol Clin Exp Res. 1994; 18: 71-80
- Modulation of T-cell adhesion markers, and the CD45R and CD57 antigens in human alcoholics.Alcohol Clin Exp Res. 1995; 19: 555-563
- Homeostasis-stimulated proliferation drives naive T cells to differentiate directly into memory T cells.J Exp Med. 2000; 192: 549-556
- Chronic ethanol consumption by mice results in activated splenic T cells.J Leukoc Biol. 2002; 72: 1109-1125
- Chronic alcohol consumption in mice increases the proportion of peripheral memory T cells by homeostatic proliferation.J Leukoc Biol. 2005; 78: 1070-1080
- Immunosenescence: deficits in adaptive immunity in the elderly.Tissue Antigens. 2007; 70: 179-189
- T cell replicative senescence in human aging.Curr Pharm Des. 2013; 19: 1680-1698
- Naive T cells: the crux of cellular immune aging?.Exp Gerontol. 2014; 54: 90-93
- Effects of moderate beer consumption on first-line immunity of healthy adults.J Physiol Biochem. 2007; 63: 153-159
- Serum levels of immunoglobulins (IgG, IgA, IgM) in a general adult population and their relationship with alcohol consumption, smoking and common metabolic abnormalities.Clin Exp Immunol. 2008; 151: 42-50
- Causes of death of alcoholics.Q J Stud Alcohol. 1972; 33: 171-185
- The impact of alcohol-related diagnoses on pneumonia outcomes.Arch Intern Med. 1997; 157: 1446-1498
- Chronic alcoholics' knowledge regarding tuberculosis.Pneumologia. 2001; 50 (1): 232-235
- Alcohol use accelerates HIV disease progression.AIDS Res Hum Retroviruses. 2010 May; 26: 511-518https://doi.org/10.1089/aid.2009.0211
- Hepatitis C and alcohol: interactions, outcomes, and implications.J Clin Gastroenterol. 2003; 36: 242-252https://doi.org/10.1097/00004836-200303000-00012
- Secondary immune response to hepatitis B virus vaccine in alcoholics.Alcohol Clin Exp Res. 1993; 17: 295-303