Highlights
- •Increased dietary fiber significantly improved blood pressure and 24 h ambulatory blood pressure in hypertensive patients.
- •Dietary fiber significantly increased the relative abundance of Bifidobacterium and Spirillum.
- •Dietary fiber (oat bran) supplement is an effective and economical method of blood pressure management.
Abstract
Background and aims
Insufficient dietary fiber (DF) intake is associated with increased blood pressure
(BP) and the mode of action is unclear. The intake of DF supplements by participants
in previous interventional studies was still far below the amount recommended by the
World Health Organization. Therefore, this study aims to explore the effect of supplementing
relatively sufficient DF on BP and gut microbiota in patients with essential hypertension
(HTN).
Methods and results
Fifty participants who met the inclusion criteria were randomly divided into the DF
group (n = 25) and control group (n = 25). All the participants received education
on regular dietary guidance for HTN. In addition to dietary guidance, one bag of oat
bran (30 g/d) supplement (containing DF 8.9 g) was delivered to the DF group. The
office BP (oBP), 24 h ambulatory blood pressure, and gut microbiota were measured
at baseline and third month. After intervention, the office systolic blood pressure
(oSBP; P < 0.001) and office diastolic blood pressure (oDBP; P < 0.028) in the DF group were lower than those in the control group. Similarly, the
changes in 24hmaxSBP (P = 0.002), 24hmaxDBP (P = 0.001), 24haveSBP (P < 0.007), and 24haveDBP (P = 0.008) were greater in the DF group than in the control group. The use of antihypertensive
drugs in the DF group was significantly reduced (P = 0.021). The β diversity, including Jaccard (P = 0.008) and Bray–Curtis distance (P = 0.004), showed significant differences (P < 0.05) between two groups by the third
month. The changes of Bifidobacterium (P = 0.019) and Spirillum (P = 0.006) in the DF group were significant.
Conclusions
Increased DF (oat bran) supplement improved BP, reduced the amount of antihypertensive
drugs, and modulated the gut microbiota.
Trial registration number
ChiCTR1900024055.
Keywords
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Article info
Publication history
Published online: April 27, 2021
Accepted:
April 12,
2021
Received in revised form:
April 11,
2021
Received:
October 22,
2020
Handling Editor: A. SianiIdentification
Copyright
© 2021 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
