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Perinatal plasma carotenoid and vitamin E concentrations with maternal blood pressure during and after pregnancy

  • Jun S. Lai
    Correspondence
    Corresponding author. Singapore Institute for Clinical Sciences, Agency for Science Technology and Research, Brenner Centre for Molecular Medicine, 30 Medical Drive, Singapore 117609.
    Affiliations
    Singapore Institute for Clinical Sciences, Agency for Science Technology and Research, Singapore
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  • Wen Lun Yuan
    Affiliations
    Singapore Institute for Clinical Sciences, Agency for Science Technology and Research, Singapore

    Université de Paris, CRESS, Inserm, INRAE, F-75004 Paris, France
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  • Choon Nam Ong
    Affiliations
    Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore
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  • Kok Hian Tan
    Affiliations
    Department of Maternal Fetal Medicine, KK Women's and Children's Hospital, Singapore
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  • Fabian Yap
    Affiliations
    Department of Paediatric Endocrinology, KK Women's and Children's Hospital, Singapore

    Duke-NUS Medical School, Singapore
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  • Yap Seng Chong
    Affiliations
    Singapore Institute for Clinical Sciences, Agency for Science Technology and Research, Singapore

    Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore
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  • Peter D. Gluckman
    Affiliations
    Singapore Institute for Clinical Sciences, Agency for Science Technology and Research, Singapore

    Liggins Institute, University of Auckland, New Zealand
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  • Keith M. Godfrey
    Affiliations
    MRC Lifecourse Epidemiology Unit & NIHR Southampton Biomedical Research Centre, University of Southampton & University Hospital Southampton NHS Foundation Trust, UK
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  • Yung Seng Lee
    Affiliations
    Singapore Institute for Clinical Sciences, Agency for Science Technology and Research, Singapore

    Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore
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  • Jerry K.Y. Chan
    Affiliations
    Duke-NUS Medical School, Singapore

    Department of Reproductive Medicine, KK Women's and Children's Hospital, Singapore
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  • Shiao-Yng Chan
    Affiliations
    Singapore Institute for Clinical Sciences, Agency for Science Technology and Research, Singapore

    Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore
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  • Mary F.F. Chong
    Affiliations
    Singapore Institute for Clinical Sciences, Agency for Science Technology and Research, Singapore

    Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore
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      Highlights

      • α-carotene, β-carotene, and lutein associate with lower blood pressure during and after pregnancy.
      • β-carotene associates with lower odds of pregnancy-induced hypertension.
      • E vitamers were not associated with blood pressure during and after pregnancy.

      Abstract

      Background and aims

      Few studies examined the influence of carotenoids and vitamin E on blood pressure or hypertension during and after pregnancy. We related perinatal plasma concentrations of carotenoids and vitamin E (in individual forms and in combination) to blood pressure and hypertension at late pregnancy and 4 years post-pregnancy.

      Methods and results

      In 684 women of the Growing Up in Singapore Towards Healthy Outcomes cohort, we quantified plasma carotenoids and vitamin E concentrations at delivery. Systolic blood pressure and diastolic blood pressure (SBP and DBP) around 37–39 weeks’ gestation were extracted from obstetric records and measured at 4 years post-pregnancy. Principal component analysis derived patterns of carotenoids (CP) and vitamin E. Associations were examined using linear or logistic regressions adjusting for confounders. Two carotenoids (CP1: α-carotene, β-carotene, and lutein; CP2: zeaxanthin, lycopene, and β-cryptoxanthin) and one vitamin E (γ-, δ-, and α-tocopherols) patterns were derived. CP1 (1SD score increment) was associated with lower SBP and DBP [β (95% CI): −2.36 (−3.47, −1.26) and −1.37 (−2.21, −0.53) mmHg] at late pregnancy> and 4 years post-pregnancy [-1.45 (−2.72, −0.18) and −0.99 (−1.98, −0.01) mmHg]. Higher β-cryptoxanthin concentrations were associated with lower SBP and DBP [-1.50 (−2.49, −0.51) and −1.20 (−1.95, −0.46) mmHg] at late pregnancy. Individual vitamin E and their pattern were not associated with blood pressure or hypertension.

      Conclusion

      Higher perinatal α-carotene, β-carotene, and lutein concentrations are associated with lower blood pressure in women at late pregnancy and post-pregnancy. Foods rich in these carotenoids, such as red-, orange-, and dark-green-colored vegetables, might be beneficial for blood pressure during and after pregnancy.

      Keywords

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