Highlights
- •Dyslipidemia is a major risk factor for cardiovascular disorders.
- •Diet and supplements can improve dyslipidemia.
- •We showed that curcumin supplementation could be effective for lipid profile.
- •Curcumin supplementation significantly reduced serum levels of LDL-C, TG and total cholesterol.
- •Curcumin intake significantly increased high-density lipoprotein cholesterol (HDL-C) levels.
Abstract
Aims
Several meta-analyses exist supporting the beneficial effects of curcumin supplementation
on lipid profile parameters; however, some studies' findings are inconsistent. Therefore,
the current umbrella of meta-analysis of clinical trials was performed to evaluate
the findings of multiple meta-analyses on the efficacy of curcumin on lipid profiles
in adults.
Data synthesis
A comprehensive systematic search of PubMed/Medline, Scopus, Embase, Web of Science
and Google Scholar were carried out up to May 2022 (in English only). Random-effects
model was employed to conduct meta-analysis. The quality assessment of the selected
meta-analyses was measured using a measurement tool to assess multiple systematic
reviews (AMSTAR). From 101 articles returned in the literature search, 19 articles
were met the qualified for inclusion in the umbrella meta-analysis. The results revealed
that the curcumin supplementation was effective on reduction of total cholesterol
(TC) (ES = −0.81 mg/dl; 95% CI: 1.39, −0.24, p = 0.006; I2 = 68.8%, p < 0.001), triglycerides (TG) (ES: 0.84 mg/dl, 95% CI: 1.42, −0.27, p = 0.004;
I2 = 84.2%, p < 0.001), and low-density lipoprotein cholesterol (LDL-C) levels (ES:
0.49 mg/dl, 95%CI: 0.85, −0.13, p = 0.007; I2 = 51.9%, p = 0.004). Beyond that, Curcumin intake significantly increased high-density
lipoprotein cholesterol (HDL-C) levels (ES: 1.34 mg/dl, 95% CI: 0.37, 2.31, p = 0.007;
I2 = 97.8%, p < 0.001).
Conclusion
Curcumin have ameliorating effects on TC, TG, LDL-c, and HDL-c levels. Overall, Curcumin
could be recommended as an adjuvant anti-hyperlipidemic agent.
Registration number
PROSPERO, CRD42021289500.
Keywords
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Article info
Publication history
Published online: August 06, 2022
Accepted:
July 27,
2022
Received in revised form:
July 25,
2022
Received:
March 9,
2022
Handling Editor: A. SianiIdentification
Copyright
© 2022 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
