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Individual and combined relationship of serum uric acid and alanine aminotransferase on metabolic syndrome in adults in Qingdao, China

  • Li Liu
    Affiliations
    Cancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong 266071, China

    Qingdao Cancer Institute, Qingdao, Shandong 266071, China

    Qingdao Municipal Center for Disease Control and Prevention, Qingdao, Shandong 266033, China

    Qingdao Institute of Preventive Medicine, Qingdao, Shandong, 266033, China
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  • Yuhan Shao
    Affiliations
    Qingdao Municipal Center for Disease Control and Prevention, Qingdao, Shandong 266033, China

    Qingdao Institute of Preventive Medicine, Qingdao, Shandong, 266033, China
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  • Xiaojing Li
    Affiliations
    Qingdao Municipal Center for Disease Control and Prevention, Qingdao, Shandong 266033, China

    Qingdao Institute of Preventive Medicine, Qingdao, Shandong, 266033, China
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  • Jianping Sun
    Affiliations
    Qingdao Municipal Center for Disease Control and Prevention, Qingdao, Shandong 266033, China

    Qingdao Institute of Preventive Medicine, Qingdao, Shandong, 266033, China
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  • Dongming Xing
    Correspondence
    Corresponding author. Cancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong 266071, China.
    Affiliations
    Cancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong 266071, China

    Qingdao Cancer Institute, Qingdao, Shandong 266071, China

    School of Life Sciences, Tsinghua University, Beijing, 100084, China
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      Highlights

      • We analyzed the individual association between alanine aminotransferase(ALT) and serum uric acid(SUA) and metabolic syndrome(MetS) using data from 4642 Chinese community residents aged 35-74 years old.
      • We explored the combined effects of ALT and SUA on MetS in individuals aged 35-74 years old.
      • There are significant relationships of elevated ALT and SUA levels with MetS. Combined elevation of ALT and SUA levels could increase the risk of having MetS and its components than an elevation in SUA and ALT alone.

      Abstract

      Background and aims

      Associations of alanine aminotransferase (ALT) and serum uric acid (SUA) with metabolic syndrome (MetS) remain controversial. We aimed to explore individual and combined effects of ALT and SUA on MetS in community residents.

      Methods and results

      A population-based cross-sectional survey involving randomly selected Chinese adults aged 35–74 years was conducted in 2009 in Qingdao, China, and 4642 participants were included in the current study. Based on a combination of SUA and ALT levels in the tertile, subjects were grouped into Group 1-9. The individual and combined relations of SUA and ALT to MetS were analyzed by logistic regression models. The prevalence of MetS was 28.50% in males and 22.30% in females. ALT and SUA were independently associated with MetS and ORs (95% CIs) were 1.55 (1.42–1.70) and 1.92 (1.72–2.14), respectively, after adjusting for potential confounders. With the elevation of ALT and SUA levels, the risk of developing MetS increased. Compared to Group 1, ORs (95% CIs) of combined ALT and SUA for MetS were 2.21 (1.70–2.88), 4.02 (3.10–5.21), 2.19 (1.62–2.97), 2.53 (1.91–3.34), 4.69 (3.60–6.12), 1.76 (1.17–2.64), 3.65 (2.63–5.06) and 7.15 (5.41–9.46) in Group 2–9, respectively.

      Conclusions

      ALT and SUA were both related to MetS independently. Combined elevation of ALT and SUA levels could increase the risk of MetS and its components than an elevation in SUA and ALT alone. Therefore, measures should be taken to lower SUA and ALT levels to reduce the risk of having MetS.

      Keywords

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