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Effects of probiotics supplementation on blood pressure: an umbrella meta-analysis of randomized controlled trials

  • Author Footnotes
    1 Meysam Zarezadeh and Vali Musazadeh have contributed equally to this work and share first authorship
    Meysam Zarezadeh
    Footnotes
    1 Meysam Zarezadeh and Vali Musazadeh have contributed equally to this work and share first authorship
    Affiliations
    Student Research Committee, Nutrition Research Center, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran

    Nutrition Research Center, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
    Search for articles by this author
  • Author Footnotes
    1 Meysam Zarezadeh and Vali Musazadeh have contributed equally to this work and share first authorship
    Vali Musazadeh
    Footnotes
    1 Meysam Zarezadeh and Vali Musazadeh have contributed equally to this work and share first authorship
    Affiliations
    Student Research Committee, Nutrition Research Center, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran

    School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
    Search for articles by this author
  • Faezeh Ghalichi
    Affiliations
    Student Research Committee, Nutrition Research Center, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran

    Nutrition Research Center, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
    Search for articles by this author
  • Zeynab Kavyani
    Affiliations
    Student Research Committee, Nutrition Research Center, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran

    School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
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  • Romina Nasernia
    Affiliations
    Science and Engineering of Food Industry, Islamic Azad University of Qazvin, Qazvin, Iran
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  • Maryam Parang
    Affiliations
    Department of Nutrition, Bushehr University of Medical Sciences, Bushehr, Iran
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  • Parmida Jamilian
    Affiliations
    School of Pharmacy and Bio Engineering, Keele University, Staffordshire, UK
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  • Parsa Jamilian
    Affiliations
    Keele University School of Medicine, Keele University, Staffordshire, UK
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  • Laleh Fakhr
    Affiliations
    Student Research Committee, Nutrition Research Center, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
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  • Alireza Ostadrahimi
    Correspondence
    Corresponding author. Nutrition Research Center, Department of Clinical Nutrition, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran. Attar-Neishaburi St., Golgasht Alley, Azadi Blvd., 5166614711 Tel.: +98 9143319531; fax: +98 4133340634.
    Affiliations
    Nutrition Research Center, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
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  • Rania A. Mekary
    Correspondence
    Corresponding author. School of Pharmacy, MCPHS University, Boston MA, 02115, USA 179 Longwood Avenue, Tel.: +1 617 879 5910.
    Affiliations
    School of Pharmacy, MCPHS University, Boston, MA, 02115, USA
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  • Author Footnotes
    1 Meysam Zarezadeh and Vali Musazadeh have contributed equally to this work and share first authorship
Published:October 10, 2022DOI:https://doi.org/10.1016/j.numecd.2022.09.005
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      Highlights

      • Hypertension is a major risk factor for cardiovascular disorders.
      • We showed that probiotics supplementation could be effective for blood pressure.
      • Probiotics supplementation significantly reduced the levels of SBP and DBP.

      Abstract

      Aims

      Several meta-analyses have revealed that probiotics could lower blood pressure, but the findings were inconsistent. In this regard, an umbrella meta-analysis was carried out to provide a more accurate estimate of the overall impacts of probiotics supplementation on blood pressure.

      Data synthesis

      We searched the following international databases till November 2021: PubMed, Scopus, EMBASE, Web of Science, and Google Scholar. A random-effects model was applied to evaluate the effects of probiotics on blood pressure. Sensitivity analysis was performed by using the leave-one-out method. Grading of Recommendations Assessment, Development, and Evaluation (GRADE) was used to evaluate the certainty of evidence. Pooled effect size of 14 meta-analyses with 15,494 participants indicated significant decreases in both systolic (Weighted mean difference (WMD)= -1.96 mmHg; 95% confidence interval (CI): -2.78, -1.14, p< 0.001, and standardized mean difference (SMD)= -2.62; 95% CI: -4.96, -0.28, p< 0.001) and diastolic blood pressure (WMD= -1.28 mmHg; 95% CI: -1.76, -0.79, p <0.001, and SMD= -0.60 mmHg; 95% CI: -1.08, -0.12, p = 0.014) following probiotics supplementation. Greater effects on SBP were revealed in trials with a mean age of >50years, and duration of intervention ≤10 weeks. DBP was also more reduced in studies with a dosage of ≥1010 colony-forming unit (CFU) and SBP was decreased in patients with hypertension or diabetes analyzing WMD.

      Conclusion

      The present umbrella of meta-analyses suggests probiotics supplementation can improve blood pressure and claims that probiotics could be used as a complementary therapy for controlling high blood pressure.

      PROSPERO ID

      CRD42022306560.

      Keywords

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