A new formula to improve the screening of impaired glucose tolerance in youths with overweight or obesity

Published:October 06, 2022DOI:



      To assess a new formula to improve the screening of isolated impaired glucose tolerance (IGT) in youth with overweight/obesity (OW/OB).

      Methods and results

      A cross-sectional study was performed in 1189 Caucasian youths with OW/OB aged 5–17 years, in whom impaired fasting glucose and high glycosylated hemoglobin were excluded. The sample was divided into training set (TS) (n = 883) and validation set (VS) (n = 306). Fasting (FG) and post-load plasma glucose, alanine aminotransferase (ALT), lipids and familial history for type 2 diabetes (FD) were available in all individuals. In the TS youths with IGT (n = 58, 7.0%) showed higher prevalence of female sex (FS), FD, and higher levels of FG, post-load glucose, ALT and lower levels of HDL-cholesterol vs individuals without IGT. The linear formula was obtained by logistic regression analysis in the TS: 0.05∗ALT + 0.07∗FG + 0.87∗FD + (0.06∗HDL∗ − 1) + 1∗FS. The best cut-off was 5.84. The performance of the formula vs IGT was: sensitivity: 0.74 and specificity: 0.71. Similar results were obtained in the VS.


      Using metabolic and anamnestic data we obtained a simple formula with a good performance for screening isolated IGT. This formula may support pediatricians to identify youths with OW/OB in whom the OGTT may be useful for detecting IGT.



      ADA (American Diabetes Association), ALT (Alanine-aminotransferase), AUC (area under curve), BMI (Body mass index), FD (Familial diabetes), FS (female sex), IFG (impaired fasting glucose), IGT (impaired glucose tolerance), HbA1c (glycosilated hemoglobin 1 c), HDL-c (High density lipoprotein-cholesterol), OB (obesity), OGTT (oral glucose tolerance test), OW (overweight), SDS (standard deviation score), TG (triglycerides), TS (training set), VS (validation set)
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