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Association between Serum Uric Acid Levels and the Prevalence of Heart Failure due to Acute Coronary Syndrome in Chinese Hospitalized Patients: A Cross-sectional Study

  • Guotong Sun
    Affiliations
    Medical College, Soochow University, Suzhou, 215000, Jiangsu, China

    Department of Cardiology, Hulunbuir People's Hospital, Hulunbuir, 021000, Inner Mongolia, China

    Department of Cardiology, Shouguang Hospital of T.C.M, Weifang, 262700, Shandong, China
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  • Yu Liu
    Affiliations
    Department of Cardiology, Hulunbuir People's Hospital, Hulunbuir, 021000, Inner Mongolia, China

    Medical College, Inner Mongolia Minzu University, Tongliao, 028000, Inner Mongolia, China
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  • Di Rong
    Affiliations
    Medical College, Soochow University, Suzhou, 215000, Jiangsu, China

    Department of Cardiology, Hulunbuir People's Hospital, Hulunbuir, 021000, Inner Mongolia, China
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  • Xiuwen Liang
    Correspondence
    Corresponding author. Medical College, Soochow University, Suzhou, 215000, Jiangsu, China.
    Affiliations
    Medical College, Soochow University, Suzhou, 215000, Jiangsu, China

    Medical College, Inner Mongolia Minzu University, Tongliao, 028000, Inner Mongolia, China

    Department of Cardiology, Hulunbeir China Mongolia Hospital, Hulunbuir, 021000, Inner Mongolia, China
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Open AccessPublished:November 06, 2022DOI:https://doi.org/10.1016/j.numecd.2022.11.006
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      Highlights

      • Find out the relationship between SUA levels and HF due to ACS.
      • Logistic regression models assess the associations of SUA levels with HF due to ACS.
      • Subgroup analysis finds ethnic-specific association between SUA and HF due to ACS.
      • Positive associations between SUA levels and HF due to ACS among Chinese patients.
      • No differences exist regarding ethnicity.

      Abstract

      Background and Aims

      Serum uric acid (SUA) may play a role in heart failure (HF). Our study was to find relationships between SUA and the prevalence of HF due to acute coronary syndrome (ACS), and the ethnic-specific relationship between them in an inpatient population.

      Methods and Results

      We analyzed 1075 Chinese ACS patients. SUA levels were cut to four groups as Q1 to Q4, according to quartiles. Binary logistic regression models were used to assess associations of SUA with HF due to ACS. Subgroup analysis was performed to find ethnic-specific association between SUA and HF due to ACS. We also performed univariate and multivariate logistic regression analyses taking into account an Italian's cut-off for SUA for HF prognosis stratification. After adjustment for all potential confounders, compared to the lowest quartile, quartiles 2, 3 and 4 had a prevalence OR of 0.69 (0.44–1.08), 1.06 (0.67–1.67) and 2.19 (1.35–3.56), respectively, for the HF due to ACS (p for trend < 0.001). Subgroup analyses didn’t reveal an ethnic-specific differences between SUA and HF due to ACS. In Han, the highest SUA level was significantly associated with the risk of HF due to ACS. OR with 95%CI for Q4 was 1.85(1.02-3.37), Q1 as a reference. For Mongolians, the OR with 95%CI for Q4 was 6.82(1.90-24.50), Q1 as a reference.

      Conclusion

      We found positive associations between SUA and the prevalence of HF due to ACS among Chinese patients. No differences exist regarding ethnicity.

      Keywords