Advertisement

Effects of a dietary intervention with Mediterranean vs lacto-ovo vegetarian diets on HDL function: results from the CARDIVEG study

Published:November 24, 2022DOI:https://doi.org/10.1016/j.numecd.2022.11.012
      This paper is only available as a PDF. To read, Please Download here.

      Highlights

      • Mediterranean diet improves HDL functionality, assessed as cholesterol efflux capacity (CEC), better than vegetarian diet.
      • Mediterranean diet is more effective than vegetarian diet on inflammatory biomarker.
      • A positive correlation was seen between the ABCA1-mediated CEC and plasma adiponectin concentration.
      • Mediterranean diet could be considered a better therapeutic strategy for cardiovascular prevention than vegetarian diet.

      Abstract

      Background and Aim

      HDL-cholesterol efflux capacity (CEC) has been shown to be a better cardiovascular (CVD) risk marker than serum HDL concentration. Several foods and nutrients have been shown to improve HDL functions, however no effective dietetic nor pharmacological strategy is available to increase CEC. This study aims to evaluate the possible effect of Mediterranean diet (MD) and lacto-ovo-vegetarian diet (VD) on HDL function in a group of clinically healthy subjects at low-to-moderate CVD risk.

      Methods and Results

      Thirty apparently healthy subjects with a low-to-moderate cardiovascular risk profile (21 F; mean age: 51.3 ± 9.7 years) were randomly assigned to a 3-month MD or VD diet and then crossed.
      Participants on VD showed a reduction in total HDL CEC by 8.99% (p<0.001) as well as a reduction in ABCA1 mediated-CEC by 18.62% (p<0.001) compared to participants on MD. Regarding CEC mediated by aqueous diffusion, no significant changes were observed after treatment with either diet. Finally, a significant positive association between CEC mediated by the ABCA1 transporter and adiponectin was found (r=0.462; p=0.010).

      Conclusion

      The results of this study suggest that HDL activity in promoting cholesterol efflux and thereby reducing the concentration of pro-atherogenic lipoproteins was more effective in participants undergoing MD than VD. Based on these findings, the MD could be considered a better therapeutic strategy for cardiovascular prevention than VD.
      Clinical Trial registration URL: http://www.clinicaltrials.gov. Unique identifier: NCT02641834.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Nutrition, Metabolism and Cardiovascular Diseases
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect