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Cumulative burden of abnormal visceral adiposity index and its components on the risk of hyperuricemia

  • Xue Tian
    Affiliations
    Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China

    Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China
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  • Shuohua Chen
    Affiliations
    Department of Cardiology, Kailuan Hospital, North China University of Science and Technology, Tangshan, China
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  • Qin Xu
    Affiliations
    China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

    Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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  • Yijun Zhang
    Affiliations
    Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China

    Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China
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  • Shouling Wu
    Correspondence
    Corresponding author. Department of Cardiology, Kailuan Hospital, North China University of Science and Technology, 57 Xinhua East Rd, Tangshan, 063000, China. Tel.: +86 315-3025655; fax: +86 315-3025655.
    Affiliations
    Department of Cardiology, Kailuan Hospital, North China University of Science and Technology, Tangshan, China
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  • Anxin Wang
    Correspondence
    Corresponding author. China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, No.119 South 4th Ring West Road, Fengtai District, Beijing, 100070, China. Tel.: +86 010-59978538; fax: +86 010-59978538.
    Affiliations
    China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

    Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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  • Yanxia Luo
    Correspondence
    Corresponding author. Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, No.10 Xitoutiao, You'anmen Wai, Fengtai District, Beijing, 100069, China. Tel.: +86 010-83911504; fax: +86 010-83911504.
    Affiliations
    Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China

    Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China
    Search for articles by this author
Published:November 15, 2022DOI:https://doi.org/10.1016/j.numecd.2022.11.016
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      Highlights

      • Cumulative burden of abnormal VAI was associated with step-wise higher risk of hyperuricemia.
      • Cumulative number of total abnormal VAI components showed an incremental association with the risk of hyperuricemia.
      • Cumulative burden of each abnormal VAI component showed a positive association with the risk of hyperuricemia.
      • Among the four components, elevated TG had the greatest increase in hyperuricemia risk.
      • The effect of cumulative burden of abnormal VAI and its components was more pronounced in females compared with males.

      Abstract

      Background and Aims

      The visceral adiposity index (VAI), a gender-specific surrogate maker of adipose tissue distribution and function, is associated with risk of hyperuricemia. However, the impact of time-burden of abnormal VAI and its components on the risk of hyperuricemia remains unknown.

      Materials and methods

      We included 56,537 participants without hyperuricemia and underwent two health examinations during 2006-2008 from the Kailuan study. Abnormal VAI burdens were evaluated as follows: (1) cumulative number of abnormal VAI presented at each examination (0-2 times); (2) cumulative number of each abnormal VAI component presented at each examination (0-2 times per component); (3) cumulative number of total abnormal VAI components presented at each examination (0-8 times).

      Results

      During a median follow-up of 8.81 years, 10,762 participants were diagnosed with hyperuricemia. The risk of hyperuricemia showed a positive association with cumulative number of abnormal VAI, the adjusted hazard ratio (HR) with 95% confidence interval (CI) of 2 times compared to 0 times was 1.69 (1.58-1.81). All four components of abnormal VAI, when diagnosed repeatedly, were independently associated with an increased risk of hyperuricemia, adjusted HR (95%CI) from 1.15 (1.02-1.28) for low high-density lipoprotein to 1.68 (1.58-1.79) for elevated triglyceride. The risk of hyperuricemia also gradually as abnormal components was accumulated from 0 to 8 counts, reaching an adjusted HR (95% CI) of 3.72 (2.64-5.23). Furthermore, the effect of cumulative abnormal VAI was more pronounced in females than males (P-interaction<0.0001).

      Conclusions

      Cumulative abnormal VAI burdens were positively associated with the risk of hyperuricemia, especially in females.

      Keywords

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